Clinical trials: Inflammatory Bowel Diseases (IBD)
Crohn's Disease
Preventing Postoperative Relapse in Crohn's Disease Patients at Risk: Azathioprine Versus Mesalazine
This study aims to compare azathioprine versus mesalazine tablets for the prevention of clinical relapse in postoperative Crohn's disease (CD) patients with moderate or severe endoscopic recurrence.
- Trial name
- NCT00946946
- Testing
- Azathioprine, Mesalazine
- Where
- 2 sites in Austria, Germany
- Volunteers
- 78 people
- Sponsor
- Dr. Falk Pharma GmbH
Kidney Calculi, Crohn's Disease
Calcium Supplements Strategy for Kidney Stones Prevention in Crohn's Patients
Hospitalization for kidney stones in the Inflammatory Bowel Disease (IBD) population is common, particularly among Crohn's patients who had a small bowel resection.
- Trial name
- NCT01735461
- Testing
- Calcium Carbonate
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Crohn Disease
Advanced Non-Invasive Diagnostics in Inflammatory Bowel Disease
The purpose of this study is to determine whether Non-invasive endoscopic procedures (pillcam colon capsule endoscopy, PCCE) and non-ionizing radiological modalities (MR enterocolonography, MREC and ultrasound, US) - offer a…
- Trial name
- ANDI (NCT03134586)
- Testing
- Diagnostic imaging
- Where
- 3 sites in Denmark
- Volunteers
- 153 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Safety Issues, Pharmacokinetic
Safety and Pharmacokinetics of Oral Controlled-ileocolonic-release Nicotinamide (CICR-NAM)
Double-blind, randomised, placebo-controlled phase I trial with single-ascending and multiple-ascending dose to evaluate safety and pharmacokinetics of oral controlled-ileocolonic-release nicotinamide (CICR-NAM) compared to…
- Trial name
- NCT05258474
- Testing
- controlled-ileocolonic-release nicotinamide (SAD/MAD/MD), Immediate-release nicotinamide (SAD)
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Ulcerative Colitis
Open-Label Adalimumab for Ulcerative Colitis Patients
This is an open-label study of 20 patients designed to demonstrate the safety, tolerability and preliminary evidence of benefit of adalimumab in the treatment of subjects with Ulcerative Colitis, both in patients who have never…
- Trial name
- NCT00421642
- Testing
- Adalimumab
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Inflammatory Bowel Diseases (IBD)
Epidemiological Evaluation Of Chronic Kidney Disease In Pediatric Patients With Inflammatory Bowel Disease
This multicenter observational cross-sectional study aims to evaluate the prevalence of chronic kidney disease (CKD) in pediatric patients with inflammatory bowel disease (IBD) and to compare it with a control group without IBD.
- Trial name
- KIBD (NCT07670988)
- Testing
- Clinical and Laboratory Data Collection
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Ulcerative Colitis, Diet Habit
Reduced Sulfur Diet in Ulcerative Colitis Patients
A)Background: Approximately 44% of patients with Inflammatory bowel disease have Ulcerative colitis(UC) which is a lifelong, chronic disease, starting in early adulthood, where the colon becomes inflamed and ulcerated due to a…
- Trial name
- UCS (NCT04474561)
- Testing
- Reduced sulfur diet
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Calgary
Inflammatory Bowel Diseases
West Hertfordshire Inflammatory Bowel Disease Technology Study
A retrospective and prospective, observational, non-interventional, cohort study to develop quantitative metrics from tools used as standard of care when diagnosing, assessing and monitoring patients with inflammatory bowel…
- Trial name
- WHITS (NCT05000242)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Perspectum
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation From Normal Pouch Function Donor in the Treatment of Chronic Pouchitis
Patients with chronic pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of the chronic…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- NCT04820413
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 3 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate
Fecal Microbiota Therapy Vs 5-aminosalicylates for Induction of Remission in Newly Diagnosed Mild-moderately Active UC
Ulcerative colitis is a chronic idiopathic inflammatory disease of the colon that is characterized by abdominal pain and bloody diarrhea.
- Trial name
- NCT03716388
- Testing
- Fecal Microbiota Transplantation, Mesalamine Granules
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Dayanand Medical College and Hospital
Ulcerative Colitis (Disorder), Guselkumab
Efficacy and Safety of Guselkumab in Patients With Moderate-to-Severe Ulcerative Colitis
In a real-world setting, this study systematically evaluates the clinical efficacy and safety of guselkumab (GUS) in the treatment of ulcerative colitis (UC), encompassing multi-dimensional outcomes including clinical remission…
- Trial name
- NCT07726888
- Testing
- Guselkumab
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Colitis, Ulcerative
An Early Phase 2 Clinical Study of KSP-0243
A phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study to administer KSP-0243 or a placebo once daily after breakfast for 8 weeks in 100 patients with mild to moderate active ulcerative…
- Trial name
- NCT05831670
- Testing
- KSP-0243
- Where
- Japan
- Volunteers
- 108 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Crohn's Disease
Study to Determine Relationship Between Serum Infliximab and Efficacy in Luminal Crohn's Disease Patients
To assess the relationship between the change in Crohn's Disease Activity Index (CDAI) scores and trough serum infliximab concentration in subjects who are scheduled to receive infliximab infusions at an interval of 8 weeks.
- Trial name
- X-Sectional (NCT00676988)
- Where
- 2 sites in Canada
- Volunteers
- 327 people
- Sponsor
- University of Western Ontario, Canada
Humoral Primary Immunodeficiencies (PIDs), Secondary Form of Humoral Immunodeficiencies
Study of Populations at Risk of Developing Chronic Hepatitis Linked to Chronic Enteric Virus Infection in Patients With Primary Immunodeficiency and Secondary Humoral Deficiency
Dysimmune and specially hepatic immuno-pathological processes are frequent in patients with PIDs (primary immune deficiencies), particularly but not exclusively in patients with humoral defects.
- Conditions
- Humoral Primary Immunodeficiencies (PIDs), Secondary Form of Humoral Immunodeficiencies, Combined Immunodeficiency (CID), Severe Combined Immunodeficiency (SCID)
- Trial name
- EVAH (NCT06659588)
- Testing
- Plasma, urine and stool collection
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
Feasibility of a Minimally Invasive Diagnostic Algorithm in Suspected Crohn's Disease
The goal of this clinical trial is to learn whether a camera pill examination of the whole bowel can be used to diagnose Crohn's disease instead of colonoscopy and a small bowel examination (either MRI or camera pill) in patients…
- Trial name
- ANDI-3 (NCT06882993)
- Testing
- Panenteric capsule endoscopy, Ileocolonoscopy, MRI enterography
- Where
- 5 sites in Denmark, Sweden
- Volunteers
- 165 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Crohn's Disease, Ulcerative Colitis
To Evaluate the Safety and Efficacy of Remsima™ in Patients With Crohn's Disease (CD) or Ulcerative Colitis (UC)
An observational, prospective cohort study to evaluate the safety and efficacy of Remsima™ in patients with Crohn's disease (CD) or Ulcerative Colitis (UC)
- Trial name
- NCT02326155
- Volunteers
- 470 people
- Sponsor
- Celltrion
Ulcerative Colitis
A Trial COmparing staNdard of Care Versus Treat to Target With telemonitoRing and Patient Education in Patients With Ulcerative cOlitis Initiating Adalimumab
PHASE: IV DESCRIPTIVE: Randomized, interventional, open label multicenter trial POPULATION: Moderate to severe ulcerative colitis STUDY TREATMENTS: Patients will all receive Adalimumab 160/80/40mg EOW until V1 (W14) followed by…
- Trial name
- CONTROL (NCT04183608)
- Testing
- Adalimumab, Calprotectin, e-Monitoring
- Where
- 24 sites in France
- Volunteers
- 238 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn Disease, Methylation
Comprehensive DNA Methylation Profiling in Crohn's Disease
Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's…
- Conditions
- Crohn Disease, Methylation, Illumina Human Methylation 850k BeadChip
- Trial name
- NCT03272152
- Testing
- Genome-wide DNA methylation
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Ulcerative Colitis
Efficacy and Safety of Modified Gegen Qinlian Decoction for Ulcerative Colitis With Damp-heat Syndrome
Ulcerative colitis(UC) seriously affect the quality of life in patients. Clinically, it is effective to apply therapeutic method of clearing heat and promoting diuresis to the common syndrome of dampness-heat.
- Trial name
- NCT04057547
- Testing
- Modified Gegen Qinlian Decoction
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Crohn's Disease
Top-down Infliximab Study in Kids With Crohn's Disease
The purpose of this study is to determine whether a top-down treatment approach, prescribing infliximab (IFX) and azathioprine (AZA) at diagnose, yields better outcome in comparison to the usual step-up treatment approach…
- Trial name
- TISKids (NCT02517684)
- Testing
- Infliximab, Prednisolone, Exclusive enteral nutrition
- Where
- 13 sites in Belgium, Finland and 1 more
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center