Clinical trials: Inflammatory Bowel Diseases (IBD)
Colon Polyps, Colorectal Cancer
Study of KCC Peptide Application in the Colon
We are studying new ways to look for abnormal areas/tissues of the colon during a colonoscopy. The current scopes used for colonoscopies are very good.
- Conditions
- Colon Polyps, Colorectal Cancer, Inflammatory Bowel Disease (IBD)
- Trial name
- KCC 1B (NCT02156557)
- Testing
- Colon KCC Heptapeptide
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Danielle Kim Turgeon
Ulcerative Colitis
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Active Ulcerative Colitis
Phase I-II Clinical Trial - Safety and efficacy of umbilical-cord-derived mesenchymal stem cell (UC-MSC) in patients with active ulcerative colitis，randomized, single blind, controlled prospective study.
- Trial name
- UCMSC-UC (NCT02442037)
- Testing
- UCMSC group, Control group(Normal saline)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Crohn's Disease
Remicade Safety Line (Crohn's Disease)(Study P03288)(COMPLETED)
This observational study is in line with the German educational plan with the aim to implement a tool to increase and monitor the awareness for tuberculosis screening and to reinforce the patient eligibility for a treatment with…
- Trial name
- NCT00818272
- Testing
- Remicade (infliximab)
- Volunteers
- 148 people
- Sponsor
- Merck Sharp & Dohme LLC
Ulcerative Colitis
Comparison Between Chromoendoscopy and Conventional Colonoscopy to Improve the Detection of Neoplasia in Patients With Ulcerative Colitis (UC)
The primary endpoint of the study will be to compare the accuracy of two procedures (FICE with target biopsies only, versus conventional white light colonoscopy with recommended targeted and random biopsies) in the endoscopic…
- Trial name
- NCT00816491
- Testing
- conventional white light colonoscopy, FICE (Fujinon Intelligent Chromoendoscopy)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Ulcerative Colitis
Study Evaluating the Long-term Safety and Efficacy of ABX464 in Active Ulcerative Colitis
This study is an open-label study aiming at evaluating the long-term safety and the efficacy profile of ABX464 given once a day (o.d) at 50 mg in subjects who have been previously enrolled in the ABX464-101 clinical study…
- Trial name
- NCT03368118
- Testing
- ABX464
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Abivax S.A.
Intestinal Disease
Study of the Prevalence of Iron Deficiency in Patients With Chronic Inflammatory Bowel Disease
Despite its known prevalence in IBD, a recent study conducted with Prof. Cacoub (unpublished) on the national health insurance database showed that iron deficiency was an under-diagnosed and under-treated co-morbidity.
- Trial name
- NCT04123990
- Testing
- Iron status testing
- Volunteers
- 1,100 people
- Sponsor
- VIFORFRANCE
Ulcerative Colitis
Efficacy, Pharmacodynamics, Safety and Tolerability of Oral BL-7040 in Patients With Moderately Active Ulcerative Colitis
The objective of the proposed study is to determine whether BL-7040 demonstrates clinical efficacy in patients with inflammatory bowel disease (IBD).
- Trial name
- NCT01506362
- Testing
- BL-7040
- Where
- 5 sites in Israel
- Volunteers
- 22 people
- Sponsor
- BioLineRx, Ltd.
Crohn's Disease, IBD
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease
This study seeks to evaluate the safety and efficacy of brazikumab versus placebo (Stage I) and versus an active comparator (Stage 2) in participants with moderately to severely active CD and will include assessments of clinical…
- Trial name
- INTREPID (NCT03759288)
- Testing
- Brazikumab low dose, Brazikumab high dose, Humira®
- Where
- 102 sites in United States, Canada and 15 more
- Volunteers
- 89 people
- Sponsor
- AstraZeneca
Crohn's Disease
Detecting Postoperative Recurrence in Crohn's Disease
Up to ¾ of patients who have been diagnosed with Crohn's disease (CD) will have to undergo bowel resection during their lifetime despite modern medical therapies.
- Trial name
- NCT00886327
- Testing
- Colonic capsule endoscopy
- Where
- 4 sites in Germany
- Volunteers
- 70 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD)
Familial Inflammatory Bowel Disease Early Risk
Brief Summary The aim of the FIBER study is to identify potential triggers associated with the later development of IBD (inflammatory bowel disease) based on baseline characteristics and biosamples (blood, urine, stool, saliva…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- FIBER (NCT07791862)
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Inflammatory Bowel Diseases, Children, Only
A Treat-to-target Strategy Using Pan-enteric Capsule Endoscopy (PCE) in Paediatric Crohn's Disease (CD).
This prospective, interventional study aims this to determine the efficacy and safety of a PCE-based treat-to-target strategy in order to achieve Mucosal Healing (MH) and deep remission (DR) of pediatric Crohn's Disease (CD) over…
- Trial name
- PCE (NCT03161886)
- Testing
- Pan-enteric Capsule Endoscopy (PCE)
- Volunteers
- 48 people
- Sponsor
- Azienda Policlinico Umberto I
Crohn Disease (CD)
Health Benefits of Tart Cherry in Crohn's Disease
Crohn's disease (CD) is a long-term inflammatory condition of the digestive tract. People with CD often experience unpredictable and debilitating symptoms, including abdominal pain, diarrhea, and fatigue.
- Trial name
- NCT06901986
- Testing
- Montmorency tart cherry
- Volunteers
- 52 people
- Sponsor
- University of Central Lancashire
Crohn's Disease
Fecal Microbiota Transplantation (FMT) in the Management of Active Crohn's Disease
Manipulation of the intestinal microbiota through FMT is a potential therapeutic target for CD patients. Studies are now required to determine if repeated FMT can overcome the apparent immune response to FMT thereby maintaining…
- Trial name
- NCT02199561
- Testing
- Fecal Microbiota Transplant
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Rheumatoid Arthritis, Crohn's Disease
The RATIO: Registry of Infections and Lymphoma in Patients Treated With TNF-a Antagonists
The RATIO registry is a French registry designed by a multidisciplinary group to collect data on opportunistic and severe bacterial infections and lymphoma in patients treated with TNF-a antagonists ( infliximab, etanercept and…
- Conditions
- Rheumatoid Arthritis, Crohn's Disease, Ankylosing Spondylitis, Psoriasis
- Trial name
- NCT00224562
- Testing
- TNF-alpha antagonists
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer, Colorectal Adenoma
Colorectal Omics and ofCS Proteoglycans (COCO) in Screening and a Diagnostic Pathway
Colorectal Cancer (CRC), or bowel cancer, is a serious disease that affects many people globally. The earlier CRC is diagnosed, the better the patient outcomes.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Inflammatory Bowel Disease (IBD)
- Trial name
- COCO-S (NCT07237984)
- Testing
- Blood sampling, Stool samplong
- Where
- 2 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Nordsjaellands Hospital
Ulcerative Colitis
An Efficacy and Safety Study of PENTASA in Chinese Patients With Left-sided Active Ulcerative Colitis Followed by a 24-Week Open-Label Extension Phase
The purpose of this study is to investigate the efficacy and safety of 4-week double-blind treatment with PENTASA enema compared with placebo enema in Chinese patients with mild to moderate active left-sided ulcerative colitis…
- Trial name
- NCT02368717
- Testing
- Mesalazine Enema
- Where
- China
- Volunteers
- 281 people
- Sponsor
- Ferring Pharmaceuticals
Inflammatory Bowel Disease, Crohn's Disease
IDeaL Pilot Study - Infliximab Dose to Level: Pilot Study
Crohn's disease (CD) is a lifelong condition of inflammation in the bowel. CD can affect any part of the gastrointestinal tract from mouth to anus.
- Trial name
- IDeaL (NCT02847884)
- Testing
- Infliximab
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- University of Alberta
Crohn's Disease
Safety and Efficacy of Treatment With Interferon Beta-1a Rebif® in Patients With Crohn's Disease
The purpose of this study is to determine the safety and efficacy of interferon beta-1a in maintaining remission in patients with Crohn's disease.
- Trial name
- NCT00304252
- Testing
- Interferon beta-1a
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 192 people
- Sponsor
- EMD Serono
Ulcerative Colitis
Saffron and Ulcerative Colitis
IBD is a chronic disease with two major types of Crohn's Disease (CD) and Ulcerative Colitis (UC). Nowadays, synthetic drugs and monoclonal antibodies are the most common types of drugs used for IBD management.
- Trial name
- NCT05117749
- Testing
- Saffron 100, Saffron 50
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Colitis, Ulcerative
An Observational Study of Etrasimod in Adult Patients With Moderate to Severe Ulcerative Colitis
The purpose of this observational study is to learn about the effects of etrasimod as a treatment for adult patients with moderate to severe ulcerative colitis.
- Trial name
- ENDEAVOUR-UC (NCT06398626)
- Testing
- Etrasimod
- Where
- 29 sites in United States
- Volunteers
- 300 people
- Sponsor
- Pfizer
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