Clinical trials: Inflammatory Bowel Syndrome
IBD (Inflammatory Bowel Disease)
Neurological Manifestations in Children Diagnosed With Inflammatory Bowel Disease
screen for neurologic and psychiatric disorders in children and adolescents with IBD.
- Trial name
- NCT07247994
- Volunteers
- 44 people
- Sponsor
- Bishoy Shehata Fahim
Premature Birth, Neonatal Hypoglycemia
Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm Babies
The goal of this observational study was to compare two doses of dexamethasone given to pregnant women at risk of preterm birth. Dexamethasone is a medicine used before birth to help a baby's lungs mature.
- Conditions
- Premature Birth, Neonatal Hypoglycemia, Maternal Infection During Pregnancy, Neurodevelopmental Disorder of Foetus
- Trial name
- NCT07765329
- Testing
- Dexamethasone 12 mg Every 12 Hours, Dexamethasone 6 mg Every 12 Hours
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Stella Maris Women and Children Hospital
Healthy, IBS - Irritable Bowel Syndrome
Microbiome Sampling in GI Disease With a Focus on Small Intestinal Microbial Assessment
GI disorders are influenced by the gut microbiome. To date, sampling of the small intestine in GI disorders has been limited. The investigators plan to sample the small intestinal contents during endoscopy for research purposes.
- Conditions
- Healthy, IBS - Irritable Bowel Syndrome, Inflammatory Bowel Diseases
- Trial name
- NCT06066866
- Testing
- endoscopic sampling of luminal fluid
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Stanford University
Menopause Related Conditions, Cardiovascular Risk
Polyphenol Metabolism and Personalized Nutrition in Menopause (PolyPause).
The study aims to evaluate the role of the gut microbiome and phageome in explaining interindividual variability in the metabolic response to polyphenol-rich nutraceuticals among menopausal women.
- Trial name
- PolyPause (NCT07182370)
- Testing
- Capsules containing plant extracts, including resveratrol, ellagic acid and isoflavones
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- National Research Council, Spain
Alcohol Use Disorder, Human Immunodeficiency Virus
Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection
Alcohol use disorder (AUD) has been associated with high prevalence of inflammation-associated co-morbidities in people living with HIV even those receiving effective antiretroviral therapy (ART).
- Trial name
- NCT06139224
- Testing
- 4 week prebiotic consumption
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Healthy, Sepsis
The Role of the Microbiota in the Systemic Immune Response
The objective of this study is to investigate the role of the gut microbiota in the systemic priming of immune effector cells. Twelve healthy male volunteers, 18-35 years of age, will be treated with broad spectrum antibiotics…
- Trial name
- MISSION-1 (NCT02340182)
- Testing
- Vancomycin, Ciprofloxacin, Metronidazole
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- W.J. Wiersinga, MD, PhD
Enteritis, Bleeding
Balloon-assisted Enteroscopy and Bacteria
1. Balloon-assisted enteroscopy (BAE) is a new tool to investigate small intestinal diseases. 2. Deep enteroscopy made possible by balloon expansion and manipulation of small intestines. 3.
- Trial name
- NCT01065324
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Analysis of Microbiota Changes Induced by Microencapsulated Sodium Butyrate in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is characterized by severe inflammation of the small bowel and/or the colon leading to recurrent diarrhea and abdominal pain.
- Trial name
- IBDMicro (NCT04879914)
- Testing
- Butyrate
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Padova
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Application of Chemical Sensors for Diagnosis of Inflammatory Bowel Diseases and Irritable Bowel Syndrome by Respiratory Samples
Discriminating irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD), especially with mild disease activity, is common clinical challenge.
- Trial name
- NCT01242163
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Diet, Healthy, Food
The PASTDUe Nutrition Ecosystem Project (PASTDUe)
This is a research study to determine if a particular method of providing nutrition improves the clinical outcomes of patients in the intensive care unit (ICU) who have undergone abdominal surgery and would require nutrition…
- Conditions
- Diet, Healthy, Food, Nutrition, Intensive Care
- Trial name
- PASTDUe (NCT05127109)
- Testing
- Nutrition Ecosystem pathway, Comparator
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Irritable Bowel Syndrome
Irritable Bowel Syndrome and Food Sensitivity
The primary objective of the clinical trial portion of this study is to assess whether an individualized dietary plan based on a commercial food sensitivity assay provides specific benefit in a randomized controlled trial in…
- Trial name
- NCT02186743
- Testing
- Personalized Dietary Advice
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Yale University
Sepsis, Urinary Tract Infections
A Study of Enterorenal Syndrome Assessed by Gastrointestinal Ultrasound Combined with Renal Artery Resistance Index
In this study, the patients with sepsis caused by abdominal infection were divided into survival group and death group by ultrasound examination of gastrointestinal function, superior mesenteric artery blood flow, and renal…
- Trial name
- NCT06505512
- Testing
- No intervention
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Zhangzhou Municipal Hospital
Gastrointestinal Hemorrhage, Crohn Disease
Prucalopride Prior to Small Bowel Capsule Endoscopy
Small bowel capsule endoscopy is a test used to investigate for any abnormalities in the small bowel. The small bowel is about 4 meters long. The battery time of the capsule is about 8 hours.
- Conditions
- Gastrointestinal Hemorrhage, Crohn Disease, Celiac Disease, Intestinal Diseases
- Trial name
- NCT02806206
- Testing
- Prucalopride
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- University of British Columbia
Ulcerative Colitis, Healthy
GI Permeability Change in Response to Aquamin®
This trial is being completed to learn about how Aquamin® affects gastrointestinal permeability, or the control of material passing from inside the gastrointestinal tract through the gut wall into the rest of the body, in people…
- Conditions
- Ulcerative Colitis, Healthy, Irritable Bowel Syndrome With Diarrhea
- Trial name
- NCT04855799
- Testing
- Aquamin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- James Varani
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
PreDiabetes, Dysbiosis
Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components
This study will investigate the gut microbiota-mediated effects of whole wheat consumption on human health in adults with pre-diabetes.
- Conditions
- PreDiabetes, Dysbiosis, Endotoxemia, Inflammation
- Trial name
- NCT05318183
- Testing
- Whole Wheat Bread, White Bread (control)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Ohio State University
Celiac Disease, Celiac Sprue
Antibody Treatment for Advanced Celiac Disease
Background: Celiac disease is a condition where the immune system attacks the cells of the small intestine. The intestine becomes inflamed and cannot digest food properly.
- Conditions
- Celiac Disease, Celiac Sprue, Gluten Enteropathy, Gluten-Sensitive Enteropathy
- Trial name
- NCT01893775
- Testing
- Hu-Mik- Beta-1
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Obesity Adult Onset
Gut Microbiota, Mitochondrial Function and Metabolic Health in Obesity
It has been suggested that individuals with the condition known as metabolically healthy obesity (MHO) may not have the same increased risk of developing metabolic abnormalities as their non-metabolically healthy counterparts.
- Trial name
- NCT06279780
- Testing
- very low-calorie diet
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Celia Bañuls
Septic Shock
Acute Intestinal Failure in Critically Ill Patients and Microbial Translocation
The hypothesis of the investigators is that patients with septic shock in ICU have acute intestinal insufficiency favoring subclinical microbial translocation, which is the consequence of alterations of the epithelium, and is…
- Trial name
- IGA-TM (NCT03861325)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes