Clinical trials: Inflammatory Conditions
Overweight or Obesity, Healthy
Berries, Inflammation, and Gut Microbiome
The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations…
- Trial name
- NCT04100200
- Testing
- Mixed berries, FOS, Control
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Dysmenorrhea, Menstrual Pain
Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea
Menstrual pain is the most common gynecological complaint and the leading cause of school and work absences in reproductive-age girls and women.
- Conditions
- Dysmenorrhea, Menstrual Pain, Non-steroidal Anti-inflammatory Drug
- Trial name
- NCT05900336
- Testing
- Sodium Naproxen
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cardiovascular Disease, Metabolic Syndrome X
Inflammatory Profiles of Children at High Risk for Atherosclerosis
The purpose of this study is to evaluate levels of inflammatory mediators in children at risk for cardiovascular disease due to family history.
- Conditions
- Cardiovascular Disease, Metabolic Syndrome X, Hypercholesterolemia, Inflammation
- Trial name
- NCT00115232
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Diabete Type 2, Obesity
Effect of Soleus Muscle Push Ups on Oxidative Stress and Inflammatory Markers, Soleus Endurance, and Adipocytokines Between Type 2 Diabetic, Overweight/Obese and Normal Weight Individuals.
The study aims to investigate the impact of Soleus Push Ups (SPU) on Soleus Muscle endurance, Oxidative Stress Markers, Inflammatory markers and Adipocytokines among people in the United Arab Emirates.
- Conditions
- Diabete Type 2, Obesity, Overweight
- Trial name
- NCT06450847
- Testing
- Soleus Muscle Push Up Exercise, Other Exercise
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Overweight, Obesity
Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men
Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease…
- Conditions
- Overweight, Obesity, Inflammation
- Trial name
- NCT00221052
- Testing
- Diclofenac
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TNO
Ulcerative Colitis, Inflammatory Bowel Disease
A Trial of Rosiglitazone for Ulcerative Colitis
This is a multicenter, randomized, double-blind, placebo-controlled study evaluating rosiglitazone: 4 mg tablets or placebo tablets administered orally twice daily for 12 weeks.
- Trial name
- NCT00065065
- Testing
- Rosiglitazone
- Where
- 13 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- James Lewis
COPD
Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study
Chronic obstructive pulmonary disease (COPD) is a common inflammatory disease of the airway affecting approximately 10% of individuals aged 40 years or more with a smoking history.
- Trial name
- NCT01780298
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Ninj1 Expression, SIRS
The Role of Ninjurin-1 During Systemic Inflammation
With the underlying study the investigators address the question if Ninjurin-1 (Ninj1) expression is altered in patients with systemic inflammatory response syndrome (SIRS) in comparison to healthy volunteers.
- Trial name
- Ninj1 (NCT02079597)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Patrick Meybohm, M.D.
Obesity, Skeletal Muscle
Anti-Inflammatory Milk Matrix
Obesity is pro-inflammatory, impairs metabolism, and physically limiting. Specifically, muscle in obese persons does not synthesize proteins normally. This further increases metabolic and physical dysfunction.
- Conditions
- Obesity, Skeletal Muscle, Inflammation
- Trial name
- AIMM (NCT04216004)
- Testing
- Controlled-Feeding Intervention, Non-dairy beverage, Full-fat milk
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps
Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria
The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria.
- Conditions
- Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps, Blood Stream Infection, Anaerobic Infection
- Trial name
- AB-care (NCT06919068)
- Testing
- Colon capsule endoscopy
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
PCOS
Endocrine, Metabolic and Inflammatory Characteristics of Offspring of Mothers With PCOS Hyperandrogenism
This study is a cross-sectional study to explore the endocrine metabolism and inflammatory characteristics of the offspring of mothers with PCOS hyperandrogenism, in order to provide a theoretical basis for finding the cause of…
- Trial name
- NCT06371313
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
Abdominal Obesity
Effect of Replacing HFCS With Sucromalt in Subjects With Raised Waist Circumference
Weight gain is linked to a high consumption of soft-drinks and other beverages sweetened with high fructose corn syrup. Being overweight increases risk for diabetes and heart disease.
- Trial name
- NCT00374218
- Testing
- High Fructose Corn Syrup, Sucromalt
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Polycystic Ovary Syndrome, Metabolic Syndrome
Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by elevated androgen levels due to ovarian overproduction.
- Trial name
- NCT06551285
- Testing
- Ovapro (Lifepro)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Celia Bañuls
Neonatal Sepsis
Clinical Impact of an Antibiotic Stewardship Program in a Neonatal Intensive Care Unit
Antimicrobial resistance is one of the biggest and most urgent threat to global health. Initiating antimicrobial stewardship programs is one of the main efforts to control antimicrobial resistance.
- Trial name
- NCT04039152
- Testing
- locally adapted neonatal sepsis treatment protocol
- Where
- Egypt
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Sepsis, Severe Sepsis
Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis
In this study, the investigators will dynamically detect the expression of an immune regulator- T cell Ig and mucin domain protein 3 (Tim-3) in patient with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02180009
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Overweight, Healthy
Absorption and Metabolic Profiles of a Sugar-based Beverage
Primary objective is to determine absorption profile of a sugar-based beverage on inflammatory mechanism by timing of beverage consumption relative to meal intake.
- Trial name
- SR (NCT02226250)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Ptosis, Eyelid, Conjunctiva Inflamed
The Effect of Upneeq (Oxymetazoline Hydrochloride 0.1%) on Eyelid Position, Eye Redness, and Eye Appearance
The purpose of the research is to see if Upneeq ( oxymetazoline 0.1% ophthalmic solution) has an effect on eyelid position, eye redness, or patient-perceived appearance of the eyes.
- Conditions
- Ptosis, Eyelid, Conjunctiva Inflamed, Eye Manifestations
- Trial name
- NCT04831047
- Testing
- Oxymetazoline hydrochloride 0.1% ophthalmic solution
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Miami
Periodontitis
Boron Levels, Oxidative Stress, and Inflammation in Periodontitis
This cross-sectional observational study aims to evaluate the relationship between boron levels and oxidative stress, antioxidant defense, and inflammatory markers in individuals with periodontitis.
- Trial name
- NCT07775378
- Testing
- Biochemical Assessment of Saliva and Gingival Tissue
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Sepsis
Assessing Immune Dysfunction in Sepsis
Sepsis leads to sustained immune system dysfunction resulting in increased susceptibility to secondary infection while in the hospital or after discharge.
- Trial name
- NCT07154615
- Testing
- Observational Only
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
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