Clinical trials: Inflammatory Conditions
Overweight, Healthy
Maximizing the Anti-inflammatory Effects of Strawberry Bioavailability
Primary objective is to determine if the efficacy of strawberries delivering polyphenols to prevent metabolic inflammation will be influenced by timing of consumption relative to meal intake.
- Trial name
- NCT01856153
- Testing
- Before meal, With Meal, After meal
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Emergency Service, Hospital, Child/Adolescent Problem
A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture
MSK-I is the most common cause for ED visits for children with pain, with a child's risk of sustaining a fracture ranging from 27-42% by the age of 16 years.
- Conditions
- Emergency Service, Hospital, Child/Adolescent Problem, Acute Pain, Fentanyl
- Trial name
- CAST (NCT02985177)
- Testing
- INF2.0 + IBU, INF1.0 + IBU
- Where
- 3 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Sepsis, Severe Sepsis
RCT of Sepsis Machine Learning Algorithm
The focus of this study will be to conduct a prospective, multi-center randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a machine-learning…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03882476
- Testing
- InSight
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dascena
Stress
The Effect of Massage Therapy to Control Night Shift Related Stress
Background: The sympathetic and parasympathetic branches (SNS and PNS) of the autonomic nervous system (ANS), keep our body in a state of balance, which can be disturbed in situations of uncontrolled stress.
- Trial name
- NCT02247089
- Testing
- Massage Therapy, Journal reading (No massage therapy)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obesity, Inflammatory Markers
Time-Restricted Feeding
We propose to conduct a randomized 6-day isocaloric crossover feeding study in humans with prediabetes and obesity. We will study the effect of restricting the timing of caloric intake to earlier in the day (TRF) versus later in…
- Conditions
- Obesity, Inflammatory Markers, Glycemic Variation, Time Restricted Feeding
- Trial name
- TRIO (NCT04884659)
- Testing
- Time restricted feeding arm, usual feeding pattern arm
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity
Metabolic Impact of Fat Digestion
In this study, the investigators are interested in investigating how the emulsification state and amount of fat in a meal can modify the kinetics of postprandial lipemia and inflammatory outcomes (including endotoxemia) in obese…
- Trial name
- LIPINFLOX (NCT01249378)
- Testing
- All subjects receive three sequences of a standard breakfast
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Obesity
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women
Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue.
- Trial name
- NCT00666874
- Testing
- lifestyle changes, Control - general information
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Pulmonary Disease, Chronic Obstructive
Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)
More patients with chronic obstructive pulmonary disease (COPD) die from cardiovascular disease than direct pulmonary complications.
- Trial name
- NCT01398943
- Testing
- Tetrahydrobiopterin (BH4), Antioxidant Cocktail
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Augusta University
Sepsis
Dynamic Alterations of Th2/Th1 With New Onset of Community-acquired Severe Sepsis Patients
To evaluate the dynamic alterations of Th2/Th1 for the prediction of clinical immunity and how it was related to 28 day-prognosis and ICU-acquired infections among critically ill patients of community-acquired severe sepsis with…
- Trial name
- NCT02883218
- Where
- China
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Jianfeng Xie
Inflammation, Obesity
Impact of a High Saturated Fat Diet on Fasted Systemic and White Adipose Tissue Inflammatory Responses
This study will investigate the effect of a 7-day westernised high-fat (65% of kilocalories), high-calorie (150% of requirements) diet on markers of inflammation in the blood and white adipose tissue.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Diseases
- Trial name
- NCT03569189
- Testing
- High Fat Diet
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Inflammatory Response
Blueberry-protein Supplementation and Exercise
This study is the human clinical trial component of an SBIR grant with Sinnovatek (funded). Cyclists (n=20) will consume a blueberry-protein, blueberry, or placebo supplement for 2 weeks prior to cycling for 2.5 h at high…
- Trial name
- NCT05596500
- Testing
- Blueberry-protein gel, Blueberry gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Quorum Sensing, Prebiotics
Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals
It has recently been discovered that bacteria are able to communicate using specialised molecules known as Quorum Sensing Signalling Molecules (QSSMs).
- Conditions
- Quorum Sensing, Prebiotics, Probiotics, Sepsis
- Trial name
- NCT01201577
- Testing
- Bifidobacterium longum BB536, Active hexose correlated compound (AHCC), Bifidobacterium longum BB536 and Active hexose correlated compound (AHCC)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Microbial Colonization
Investigate"Clinically" the Effectiveness of Boswellia Based Intracanal Medication Compared to Calcium Hydroxide Ca(OH)2 and Ledermix on the Levels of Bacteria and Inflammatory Cytokines in Root Canals and Periradicular Tissues of Teeth With Apical Periodontitis
The objective of this study is to investigate "clinically" the effectiveness of Boswellia based intracanal medication compared to the commonly used intracanal medicaments (calcium hydroxide Ca(OH)2 and Ledermix) on the levels of…
- Trial name
- NCT06466538
- Testing
- Calcium hydroxide, Leddermix, Boswellia
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Sepsis
PyroEVs/PLIN3 Mediate Lipid Droplet-Mitochondrial Coupling in Sepsis Endothelial Injury
Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients. Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of…
- Trial name
- NCT07727265
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Zhongda Hospital
Sepsis
Pro-adrenomedullin as a Prognostic Marker in Neonatal Sepsis
The aim of this study was to clarify the prognostic value of serum pro-Adrenomedullin level in neonatal sepsis. Eighty term and preterm neonates with sepsis were enrolled in this study.
- Trial name
- NCT01362504
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
General Health and Wellness, Energy and Vitality
M4C Nutraceutical Intervention Human Health Effects Pilot
This 3 month pilot study will be an unblinded, convenience sampling, nutraceutical intervention trial. Twenty fasted subjects will undergo a baseline health assessment via a questionnaire, baseline clinical chemistries, blood…
- Conditions
- General Health and Wellness, Energy and Vitality, Cognitive Function and Mental Health, Weight Management
- Trial name
- M4C Pilot (NCT06476236)
- Testing
- M4C
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Concordia University Wisconsin
COPD
Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study
Chronic obstructive pulmonary disease (COPD) is a common inflammatory disease of the airway affecting approximately 10% of individuals aged 40 years or more with a smoking history.
- Trial name
- NCT01780298
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery
This study evaluates the influence of Non-steroidal Anti-inflammatory Drugs on preventing fever after the removal of drainage tube in the patients who suffered lumbar fusion surgery, if the outcome turn out positive, the…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Radiculopathy
- Trial name
- NCT04042948
- Testing
- Tylenol
- Where
- China
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Inflammatory Bowel Diseases
Regulation of Mucosal Healing in Inflammatory Bowel Disease
The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid…
- Trial name
- NCT04504136
- Testing
- Serial Biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Terrence A Barrett
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.