Clinical trials: Inflammatory Conditions
Inflammatory Response, Microbial Colonization
Microbial Adhesion and Biofilm Formation on Denture Base Materials
Polymethylmethacrylate (PMMA) has been the material of choice for fabricating complete dentures for more than 80 years now.(1,2) As a material it is easy to handle and can be easily repaired and polished.
- Conditions
- Inflammatory Response, Microbial Colonization, Denture Stomatitis
- Trial name
- NCT06395116
- Testing
- Denture base material
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Athletic Performance, Oxidative Stress
Ergogenic and Antioxidant Effects of Corinthian Currant
The purpose of the present study is to investigate the effect of pre-exercise supplementation of Corinthian currant on metabolism, performance and blood redox status during, and after an acute bout of prolonged exercise.
- Conditions
- Athletic Performance, Oxidative Stress, Inflammation
- Trial name
- NCT03288064
- Testing
- Corinthian currant, Glucose drink, Water ingestion
- Where
- Greece
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Obesity, Hyperlipidemia
Effects of Glutathione (an Antioxidant) and N-Acetylcysteine on Inflammation
The rationale for the potential role of antioxidants in the prevention of cardiovascular diseases (CVD) remains strong despite the disappointing results of recent trials with a few select antioxidant vitamins.
- Conditions
- Obesity, Hyperlipidemia, Insulin Resistance, Hypertension
- Trial name
- NCT01550432
- Testing
- Glutathione, N-Acetylcysteine
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diet, Healthy, Endotoxemia
Different Dietary Patterns
The aim of the present study is to determine the effects of different standardized dietary patterns on general health markers, intestinal function, immune response and affective processes/ cognitive skills in healthy subjects.
- Trial name
- NCT06147440
- Testing
- Dietary intervention
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Pain, Inflammation
Acupuncture for Inflammatory Pain and Central Sensitization - A Pilot Study
Acupuncture is used extensively by patients worldwide for a variety of illnesses. While research is beginning to show effectiveness in clinical pain, the mechanisms underlying how these effects are evoked are poorly understood.
- Trial name
- NCT01945190
- Testing
- Electroacupuncture
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Inflammation, Periodontitis
Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease
This research study has 2 aims. One aim is to see if saliva testing can show if a person has healthy gum tissue, gingivitis, or one of three degrees of periodontitis - mild, moderate, or severe.
- Trial name
- NCT02187185
- Testing
- Sonicare/Elite-Flexcare Toothbrush, Manual Toothbrush
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Operation Site Inflammation, Pain, Postoperative
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar
Clinical and preclinical studies have demonstrated encouraging results of non-steroidal anti-inflammatory drug (NSAID) chronotherapy in the management and treatment of inflammatory diseases such as rheumatoid arthritis.
- Conditions
- Operation Site Inflammation, Pain, Postoperative, Teeth, Impacted
- Trial name
- NCT03789058
- Testing
- Ibuprofen 400 mg
- Where
- Jordan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Neoplasms, Antioxidants
Oxidoreductive Balance and Lysosomal Activity in Cancer Patients.
The research aims to determine the parameters of oxidative stress and inflammatory processes and compare these parameters with the image obtained using positron emission tomography (PET) with 2-deoxy-2-[fluorine-18]fluoro…
- Conditions
- Neoplasms, Antioxidants, Oxidative Stress, Lipid Peroxidation
- Trial name
- NCT03470857
- Testing
- Patients
- Where
- 3 sites in Poland
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Nicolaus Copernicus University
Chronic Granulomatous Disease, Inflammatory Bowel Disease
Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations
Background: PIDD stands for primary immune dysregulation. It is a general term that includes many different inherited immune system disorders. The immune system is the part of the body that helps fight disease and infection.
- Trial name
- NCT03278912
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity, Circadian Dysregulation
Impact of Blueberry Consumption on Gastrointestinal Health
This study will evaluate the impact of blueberry consumption on markers of gastrointestinal health including gut microbiota, intestinal permeability, and gut-derived inflammation in those vulnerable to a unhealthy gut milieu.
- Trial name
- NCT03934177
- Testing
- Blueberry powder
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Cystic Fibrosis, Oxidative Stress
Flaxseed Modulates Inflammation and Oxidative Stress in CF
Flaxseed (FS) is a safe and well tolerated supplement with an ability to fight inflammation and oxidative stress - a byproduct of daily stress the human body faces everyday and especially with chronic diseases.
- Conditions
- Cystic Fibrosis, Oxidative Stress, Inflammation
- Trial name
- NCT02014181
- Testing
- finely ground flaxseed powder
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Metabolic Syndrome X, Insulin Resistance
Oral Contraceptives in the Metabolic Syndrome
Oral contraceptives (OCs) are the most widely used method of reversible birth control. However, the long-term cardiovascular safety of the widely used low-dose OCs (ethinyl-estradiol < 50 mcg) is still debated.
- Conditions
- Metabolic Syndrome X, Insulin Resistance, Obesity, Cardiovascular Diseases
- Trial name
- NCT00205504
- Testing
- Ortho Tri Cyclen
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Vaginal Infection, Pregnancy Complications
Oral Probiotics to Reduce Vaginal Group B Streptococcal Colonization in Late Pregnancy
In the present study, the investigators aim to evaluate the potential of oral probiotics, containing Lactobacillus strains, to eradicate and reduce the vaginal colonization with group B Streptococcus (GBS) during pregnancy.
- Conditions
- Vaginal Infection, Pregnancy Complications, Neonatal Sepsis, GBS
- Trial name
- NCT03008421
- Testing
- Astarte® (HSO Health Care GmbH, Vienna, Austria)
- Where
- Austria
- Volunteers
- 1,058 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Asthma, Chronic Obstructive Pulmonary Disease
Measurement of Soluble Factors and Particulate Matter in Induced Sputum and EBC in Inflammatory Diseases of the Lung
In the present study inflammatory mediators will be isolated in induced sputum and exhaled breath condensate and will be correlated with particulate matter measured in these samples.Particulate matter will be assessed by partcle…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Interstitial Lung Diseases, Occupational Lung Diseases
- Trial name
- NCT00511290
- Testing
- no generic names
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Inflammation, Analgesia
Comparison of the Effects of Dexmedetomidine and Ketamine Infusion on the Inflammatory Response in Liver Resection
Resection is being performed with increasing frequency in the treatment of surgical diseases of the liver. Ischemia-reperfusion injury is a major cause of liver injury occurring during surgical procedures, including hepatic…
- Trial name
- NCT06219928
- Testing
- Control Group, Ketamine Group, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Hiv, Transmission Vertical
Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV
Mentor Mothers (MMs) are peer supporters who help pregnant and postpartum women living with HIV (WLHIV) as they receive prevention of mother-to-child transmission of HIV (PMTCT) services in resource-limited settings like Kenya.
- Conditions
- Hiv, Transmission Vertical, Viremia, Adherence, Treatment
- Trial name
- PIE-eMMs (NCT06999928)
- Testing
- Enhanced Mentor Mother Strategy
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
Inflammation
To Demonstrate the Relative Bioavailability of Diclofenac Sodium 50 mg Enteric-Coated Tablets
To demonstrate the relative bioavailability of Diclofenac Sodium 50 mg enteric-coated tablets.
- Trial name
- NCT00913224
- Testing
- Diclofenac Sodium 50 mg Tablets (Geneva Pharmaceuticals, Inc), Voltaren 50 mg Tablets (Geigy Pharmaceuticals)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Sandoz
Sepsis, Septic Shock
Evaluation of Blood Protein O-GlcNAcylation Levels in Children
Stimulation of O-GlcNAcylation has been shown to be beneficial in several acute pathologies and different animal models, such as haemorrhagic and septic shock, and ischaemia-reperfusion (cerebral and cardiac).
- Conditions
- Sepsis, Septic Shock, Development and Health, Metabolism Changes
- Trial name
- CHANCE (NCT06754696)
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Pro-inflammatory Activity, Immunologic Activity Alteration
Pain, Opioids and Pro-Inflammatory Immune Responses
Providing pain management to the patient who abuses prescription opioids presents a clinical challenge, not only due to concerns about "drug-seeking", but because they have increased sensitivity to pain, a phenomenon identified…
- Trial name
- NCT01210066
- Testing
- Fentanyl, Cold pressor test, Fentanyl plus cold pressor test
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
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