Clinical trials: Inflammatory Conditions
Oxidative Stress, Inflammation
Influence of a Short Term Supplementation With Ubiquinol on Diverse Aspects Related to the Physical Activity
The General Aim of this study is to verify if a short term supplementation can modulate diverse aspects related to the physical regular high intensity activity.
- Conditions
- Oxidative Stress, Inflammation, Muscle Injury
- Trial name
- NCT01940627
- Testing
- Ubiquinol, Control
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Vestibular Disorder, Headache
The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury
Test the hypothesis that a certain set of osteopathic manipulation procedures preformed on patients with mild to moderate traumatic brain injury will result in accelerated rates of recovery assessed using vestibular function…
- Conditions
- Vestibular Disorder, Headache, Traumatic Brain Injury
- Trial name
- NCT03163901
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Hepatitis B, Chronic
Observe Change of Endotoxaemia and Related Mediators in Patients With Chronic Hepatitis B Virus (HBV) Infection
This study was designed for changes in endotoxaemia, endotoxin-binding factors, sICAM-1 (soluble intracellular adhesion molecule-1), and cytokines during progression of chronic HBV infection.
- Trial name
- OCEHBV (NCT01107483)
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Malaria
Blood-Stage Plasmodium Vivax Cell Bank
Background: Malaria is caused by a parasite (a type of germ called P. vivax) that is carried by mosquitoes. The disease is transmitted to people when they are bitten by infected mosquitoes.
- Trial name
- NCT05095272
- Testing
- HMPBS02-Pv
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intermittent Explosive Disorder
Inflammatory Challenge in Human Aggression.
The goal of this clinical trial is to explore the differences in behavioral and cytokine response to a low dose infusion of endotoxin (vs.
- Trial name
- LPSS (NCT06665074)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cognitive Change, Mood
Cognitive, Mood, Anti-Inflammatory and Metabolic Effects of Chronic Oyster Mushroom Intervention in Older Adults
The Pleurotus oyster species is a common edible mushroom rich in phytochemicals such as proteins, phenolic compounds, dietary fibre and is also particularly rich in ergothioneine, a bioactive known for its neurocognitive…
- Conditions
- Cognitive Change, Mood, Metabolism, Inflammatory Response
- Trial name
- OYSCOG (NCT06846827)
- Testing
- Oyster mushroom, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Reading
Postoperative Delirium
Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia
Postoperative delirium after total knee replacement surgery has been related to significant morbidity and mortality among high risk patients. Anesthetic care might play a role in the development of postoperative delirium.
- Trial name
- NCT03120442
- Testing
- Propofol, Dexmedetomidine, Fentanyl
- Where
- Thailand
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Crohn Disease, Recurrence
Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease.
The study is looking at the role of the mesentery in disease recurrence for ileocolic Crohn's disease. It is a prospective study that has been designed to perform extended mesenteric excision on patients undergoing their first…
- Conditions
- Crohn Disease, Recurrence, Crohn's Ileocolitis
- Trial name
- NCT04539665
- Testing
- Extended mesenteric resection.
- Where
- 2 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Montreal General Hospital
Ulcerative Colitis
The Contact Activation System and Ulcerative Colitis
The study aims to describe alterations in the contact activation system during active and inactive ulcerative colitis. Contact activation system measures are compared in a cross sectional (healthy controls vs.
- Trial name
- NCT04621006
- Testing
- Continuously assessment of disease activity
- Where
- Denmark
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Psoriasis, Inflammation
Regulation of Inflammatory Genes in Psoriasis
Psoriasis is a chronic and recurrent skin disorder characterized by marked inflammatory changes in the skin. An extensive cytokine network including generated by activated dendritic cells and T cells mediates the formation of…
- Trial name
- NCT03125655
- Testing
- Inflammatory markers
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Sexual Dysfunction, Endothelial Dysfunction
Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men
This study aims to compare the effects of 8 months of diet modification, with or without exercise, on weight loss, sexual, urinary and endothelial function, systemic inflammation and quality of life in obese men.
- Conditions
- Sexual Dysfunction, Endothelial Dysfunction, Quality of Life, Inflammation
- Trial name
- NCT01642576
- Testing
- weight loss counselling
- Where
- Singapore
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Sepsis, Septic Shock
Molecular Subtype-Specific Mechanisms and Therapeutic Strategies in Sepsis
Sepsis is a complex syndrome that causes lethal organ dysfunction due to an abnormal host response to infection. No drug specifically targeting sepsis has been approved.
- Trial name
- MENDSEP (NCT06287684)
- Where
- Malta
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Mater Dei Hospital, Malta
Inflammation, Cancer
Ashwagandha: Effects on Stress, Inflammation and Immune Cell Activation
Ayurvedic medicine has been practiced in for more than 2,500 years. Ashwagandha is one of the most widely utilized herbs in the system. It is thought to affect the endocrine, immune, nervous, and cardiopulmonary systems.
- Conditions
- Inflammation, Cancer, Autoimmune Diseases
- Trial name
- NCT00817752
- Testing
- Ashwagandha
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
NAFLD, Obesity
Intermittent Fasting, Mediterranean Diet and NAFLD
This study aims to evaluate the effects of Intermittent Fasting (IF) 14/10 compared with the Low Glycemic Index Mediterranean Diet on NAFLD.
- Conditions
- NAFLD, Obesity, Intermittent Fasting, Mediterranean Diet
- Trial name
- RC2024-21 (NCT06615817)
- Testing
- Intermittent Fasting
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Viremia
Yellow Fever Virus Vaccine and Immune Globulin Study
The purpose of this study is to determine whether immune globulin can limit the amount of yellow fever vaccine virus present in the blood after vaccination without compromising the immunity associated with the yellow fever…
- Trial name
- NCT00254826
- Testing
- YF-VAX® plus saline, 17D YF Vaccine plus Ig,
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Malaria
Dose Escalation PfSPZ-CVac
Background: People get malaria from bites from infected mosquitos. Researchers are studying a vaccine strategy. They will give people malaria parasites by injecting them with live infectious malaria parasites with antimalarial…
- Trial name
- NCT03083847
- Testing
- Chloroquine Phosphate, Pyrimethamine, Sanaria PfSPZ Challenge
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acne
Evaluation of Effaclar Duo+M on Acne Lesions in Subjects With Mild to Moderate Acne on Face and Trunk
This single-center, open, non-randomized study aims the efficacy evaluation of Effaclar Duo+M and Effaclar+M Purifying foaming gel on total acne lesion count, pigmented lesions and scars for 6 months in subjects with mild to…
- Trial name
- NCT06463925
- Testing
- acneic participants group
- Where
- Brazil
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Inflammation, Inflammatory Response
Cannabis Observational Study on Mood, Inflammation, and Cognition
This project examines the effects of cannabis on cognition and other domains of function and whether those effects are dependent upon the ratio of THC to CBD in the product.
- Conditions
- Inflammation, Inflammatory Response, Mood, Cognitive Change
- Trial name
- COSMIC (NCT03522103)
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
T Lymphocyte Disorder
MiRNAs Evaluating Lymphocyte Proliferation and Apoptosis as Well as Prognosis of Sepsis
Sepsis is a systemic inflammatory reaction caused by infection, trauma, etc. In the process of sepsis, the apoptosis of lymphocyte serves as a vital factor of immune dysfunction.
- Trial name
- NCT02756559
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lixin Xie
Bacteremia
The Impact of Material on Microbiota in Association With Tongue and Lip Piercing
Biofilms on oral piercings may serve as a bacterial reservoir and lead to systemic bacteraemia or local transmission of periopathogenic microbiota.
- Trial name
- NCT01039259
- Testing
- piercings of four different materials
- Where
- Austria
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
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