Clinical trials: Inflammatory Conditions
Inflammatory Bowel Disease (IBD), Dysbiosis
Oral Microbiota Dysbiosis in IBD
This study aims to provide new insights into oral microbiota dysbiosis and IBD. Given the strong association between oral health, microbiome composition, and IBD, all participants will undergo an oral evaluation program conducted…
- Trial name
- MIBD (NCT06980818)
- Testing
- No intervention
- Where
- Portugal
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- ULS Viseu Dão Lafões
Metabolic Syndrome
Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment
To determine whether the combination of ezetimibe and simvastatin improves biomarkers of atherothrombosis compared to simvastatin alone in patients with the metabolic syndrome.
- Trial name
- NCT00819403
- Testing
- simvastatin, ezetimibe/simvastatin
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Pain, Inflammation
Acupuncture for Inflammatory Pain and Central Sensitization - A Pilot Study
Acupuncture is used extensively by patients worldwide for a variety of illnesses. While research is beginning to show effectiveness in clinical pain, the mechanisms underlying how these effects are evoked are poorly understood.
- Trial name
- NCT01945190
- Testing
- Electroacupuncture
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Sepsis
Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational Study
Sepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ dysfunction and increased mortality.
- Trial name
- EMR3-SEPSIS (NCT07896018)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Systemic Inflammatory Response Syndrome, Sepsis
Alpha-1-acid Glycoprotein as a Biomarker of Developmental Diagnosing and Monitoring Effectiveness in Sepsis
To assess the potential value of alpha-1-acid glycoprotein (AGP) for early diagnosis and prognosis of patients with sepsis, and then compared with C-reactive protein (CRP), procalcitonin (PCT), white blood cell (WBC) counts…
- Trial name
- NCT01838525
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Intrauterine Growth Restriction
Study of the Fetal and Maternal Microbiota in Preganant Women With Fetal Defect Growth
It is an observational and prospective study that will include consecutively 63 controls (fetuses with estimated fetal weight above the 10th centile) and 63 fetuses with defects in fetal growth (estimated fetal weight below the…
- Trial name
- BIOCIR (NCT04047966)
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Hypertriglyceridemia With the Metabolic Syndrome
Effects of Micronized Fenofibrate on Fasting and Postprandial Lipoproteins, Inflammatory Mediators and Thrombosis
This is a randomized placebo controlled clinical trial designed to investigate the effects of micronized fenofibrate on fasting and postprandial lipoproteins, oxidized fatty acids and lipoproteins, inflammatory mediators and…
- Trial name
- NCT00422396
- Testing
- Fenofibrate (drug)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Skin Infection
Skin Inflammation and PK of Azithromycin
This study will investigate the tissue distribution of azithromycin in healthy, artificially inflamed and actually infected tissue of humans.
- Trial name
- AZI_IMQ_LPS (NCT06170983)
- Testing
- Azithromycin, Biopsy, Skin inflammation model
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hypertension, Inflammation
The Role of the Immune and Inflammatory Systems in Hypertension
To define the cytokine and cellular immune signature of primary hypertension. Cross sectional clinical/laboratory study.
- Conditions
- Hypertension, Inflammation, Vascular Diseases
- Trial name
- NCT04015635
- Testing
- None involved
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Healthy
The Influence of IgY Max on Inflammatory Markers and the Gut Microbiome
The purpose of this study is to determine the optimal dose of IgY as assessed by changes in the inflammatory marker, C-reactive protein and investigate the effect of IgY on the gut microbiome as assessed by 16s RNA sequencing of…
- Trial name
- NCT02972463
- Testing
- Immunoglobulin Y
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Igy Nutrition, LLC
Surgical Complication, Pain, Postoperative
Anti-inflammatory Effect of Platelet-Rıch Fıbrın
This study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters.
- Conditions
- Surgical Complication, Pain, Postoperative, Edema Face
- Trial name
- NCT05336578
- Testing
- Platelet rich fibrin application
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nilay Er
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuropathy With Antibody A MAG
The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a promising growing field (1). Non-invasive and painless, ultrasound provides additional data electroneuromyography (EMG), with a spatial…
- Trial name
- EchoNerf (NCT03008733)
- Testing
- Ultrasound UHF peripheral nerves, Electro myography surface nerves
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Inflammation, Periodontitis
Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease
This research study has 2 aims. One aim is to see if saliva testing can show if a person has healthy gum tissue, gingivitis, or one of three degrees of periodontitis - mild, moderate, or severe.
- Trial name
- NCT02187185
- Testing
- Sonicare/Elite-Flexcare Toothbrush, Manual Toothbrush
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Sepsis
Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers
The aim of this study is to determine if oxytocin administration is able to blunt LPS induced increase of cytokines (TNF-α) and if there is a change in the endocrine response after lipopolysaccharide administration in humans.
- Trial name
- NCT00360048
- Testing
- oxytocin
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Sepsis
Lactate Metabolism After an Endotoxin Challenge in Healthy Humans
Sepsis is characterized by hyperlactatemia, the severity of which is proportionate with sepsis severity. The pathophysiological mechanisms (increased lactate production vs decreased lactate utilization; tissues involved in…
- Trial name
- NCT01647997
- Testing
- bacterial endotoxin challenge
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Inflammation, Interleukin-1beta
Effect on Cytokines IL-1ß, TNF-α, IL-4, and Total Bacterial Load of a Composition Comprising Olive Oil, Trimethylglycine and Xylitol Delivered as a Toothpaste
The goal of this clinical trial is to learn if a novel composition comprising olive oil, trimethylglycine and xylitol, affects salivary levels of IL-1ß, TNF-α and IL-4 in a group of periodontally healthy, normal and…
- Conditions
- Inflammation, Interleukin-1beta, TNF-α, Cytokine Levels
- Trial name
- NCT06786910
- Testing
- Toothpaste with olive oil, trimethylglycine and xylitol, Toothpaste without olive oil, trimethylglycine nor xylitol
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mucosa Innovations, S.L.
Sepsis
Novel Biomarkers Related Xuebijing Injection Improves Sepsis
Sepsis is a life-threatening clinical syndrome of organ dysfunction caused by dysregulation of the body's response to infection, and is a common cause of ICU admission for critically ill patients, posing a serious threat to human…
- Trial name
- NCT06920420
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Colonic Polyps, Cancer Colon
Evaluation of Reduced-volume PEG Bowel Preparation Administered the Same Day of Colonoscopy
The conventional total dose of 4 L of polyethylene glycol (PEG) given the day before the procedure is safe and effective. It has been the standard cleansing regimen for the last 25 years.
- Conditions
- Colonic Polyps, Cancer Colon, Inflammatory Bowel Disease
- Trial name
- LowVolumePEG (NCT01533090)
- Testing
- polyethylene glycol (PEG), PEG low volume with bisacodyl
- Where
- Italy
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Colon Cancer, Breast Cancer
SurgicAl Metabolic Phenotyping Longitudinal Evaluation Study
This work will use a new approach to measure how surgery effects human biochemistry and metabolism. It will create a metabolic signature or 'phenotype' for surgical injury that will help clinicians choose the right surgical…
- Conditions
- Colon Cancer, Breast Cancer, Trauma, Inflammatory Bowel Disease
- Trial name
- SaMPLE (NCT01378013)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
PCOS
Endocrine, Metabolic and Inflammatory Characteristics of Offspring of Mothers With PCOS Hyperandrogenism
This study is a cross-sectional study to explore the endocrine metabolism and inflammatory characteristics of the offspring of mothers with PCOS hyperandrogenism, in order to provide a theoretical basis for finding the cause of…
- Trial name
- NCT06371313
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
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