Clinical trials: Inflammatory Disease Activity
Primary Progressive Multiple Sclerosis, Primary Progressive MS
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
The goal of this Phase 2 clinical trial is to investigate the safety and tolerability of SUN-627 in men and women aged 18-70 years old with a diagnosis of non-active SPMS/PPMS.
- Conditions
- Primary Progressive Multiple Sclerosis, Primary Progressive MS, Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive MS (SPMS)
- Trial name
- NCT07840326
- Testing
- SUN-627
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sundance Biosciences, Inc.
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy
Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study
The project aims to investigate the validity, and reliability of outcome measures of muscle strength, functioning (gait, balance, and fine motor skills), physical activity, and patient-reported outcome measures of functioning…
- Conditions
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy, POEMS Syndrome, Multifocal Motor Neuropathy
- Trial name
- PolyImPAct (NCT06040567)
- Testing
- Validity and reliability of outcome measures in polyneuropathy, Healthy controls
- Where
- Denmark
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Inflammatory Bowel Disease
Physical Activity and Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
This study is an observational study. The purpose of this study is to assess the relationship between bone health and daily physical activity in children and adolescents with inflammatory bowel disease (IBD).
- Trial name
- PHYSICOSMICI (NCT02341742)
- Testing
- multiple examinations
- Where
- 7 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Lille
Healthy Lifestyle, Home Environment Related Disease
HomeStyles-Adults of Chinese Heritage
Individuals of Chinese heritage are the largest and fastest growing segment of the US Asian population. US Chinese have sociodemographic characteristics and culture that differ substantially from other US Asians, and therefore…
- Conditions
- Healthy Lifestyle, Home Environment Related Disease, Cardiometabolic Disease, Systemic Inflammatory Response
- Trial name
- NCT06136793
- Testing
- HomeStyles-China
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Inflammatory Bowel Disease
Impact of a Structured Therapeutic Education Session on the Practice of Adapted Physical Activity in Chronic Inflammatory Bowel Diseases
Chronic inflammatory bowel diseases (IBD; including Crohn's disease and ulcerative colitis) significantly impact patients' quality of life.
- Trial name
- ETAP-MICI (NCT07305454)
- Testing
- Inflammatory Bowek Disk Questionnaires, Short-International Physical Activity Questionnaries
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Toulouse
Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
Analysis of Barriers and Facilitators to Adapted Physical Activity for Pediatric Patients With Chronic Inflammatory Bowel Diseases
This study aims to identify perceived barriers and facilitators to regular physical activity among children and adolescents with inflammatory bowel disease (IBD) followed in pediatric gastroenterology.
- Trial name
- Feels-Mici (NCT07383844)
- Testing
- IMPACT-III questionnaires, Data collection: CAPAS-Q, semi-structured interview
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Lenval
Inflammatory Bowel Disease (IBD)
Personalized Exercise Coaching to Improve Quality of Life in Pediatric IBD
The primary objective of this research is to gain novel insights into the potential of physical activity in reducing fatigue, improving QoL and GI manifestations in children with IBD.
- Trial name
- FIT4IBDKids (NCT07355101)
- Testing
- Intake session to define individualized physical activity goals, Personalized Motivational Coaching, 24 Week Exercise Programme
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Universiteit Antwerpen
Crohn's Enteritis, Crohn Disease
Impact of a Physical Activity Program on Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
Muscle and physical activity play an important role in in growth, development and bone health in healthy children, especially during puberty.
- Conditions
- Crohn's Enteritis, Crohn Disease, Ulcerative Colitis, Chronic; Colitis (Noninfective)
- Trial name
- PROPHYSICOS (NCT03774329)
- Testing
- Usual care, adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille
Inflammatory Bowel Disease (IBD), Disease Activity
Evaluation of Intestinal Lesions and Disease Activity in Inflammatory Bowel Disease Based on 18F-FAPI PET Imaging
The goal of this observational study is to evaluate the role and effect of 18F-FAPI PET imaging in the identification of intestinal lesions and the assessment of disease activity in inflammatory bowel disease.
- Conditions
- Inflammatory Bowel Disease (IBD), Disease Activity, FAPI
- Trial name
- IBD，18F-FAPI (NCT06945549)
- Testing
- 18F-FAPI PET Imaging
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Crohn Disease (CD), IBD (Inflammatory Bowel Disease)
Abdominally Targeted Management Exercises for Crohn's Disease Patients (TAME-CD)
The goal of this clinical trial is to learn if abdominally targeted exercises can assist to manage disease activity in Crohn disease (CD) patients.
- Trial name
- NCT06917443
- Testing
- Abdominally targeted exercises, General exercises
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Shmuel Kivity, MD
Inflammatory Bowel Diseases, Physical Activity
Physical Activity and Sedentary Behaviour in Patients With Inflammatory Bowel Disease
Emerging research suggests that physical activity may improve health-related quality of life (HrQoL) in patients with inflammatory bowel disease (IBD) and positively influence physical symptoms, fatigue, stress and anxiety.
- Conditions
- Inflammatory Bowel Diseases, Physical Activity, Sedentary Behavior, Feasibility Study
- Trial name
- PASIBO (NCT06106607)
- Testing
- Intervention group
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Center for Clinical Research and Prevention
Inflammatory Bowel Diseases
Study on Lipid Profile Changes in Plasma and Intestinal Mucosa of Patients With Inflammatory Bowel Disease
This study aimed to demonstrate the characteristic lipid profile changes in patients with inflammatory bowel disease.
- Trial name
- NCT06680076
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Axial Spondyloarthrithis, Inflammatory Diseases
EXercise Therapy in Axial SpA, Inflammation and Biologic Therapy (ExTASI-B)
The goal of this randomised controlled trial study is to investigate whether exercise (brisk walking, equal to 13 on a rating of perceived exertion scale; somewhat hard) can be used as an adjuvant therapy for people living with…
- Conditions
- Axial Spondyloarthrithis, Inflammatory Diseases, Arthritis
- Trial name
- ExTASI-B (NCT06669702)
- Testing
- 12-week home based exercise, Routine care
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Inflammatory Bowel Diseases
The Effect of Intensive Physical Exercise on Fatigue and Quality of Life in Patients With Quiescent Inflammatory Bowel Disease
In patients with inflammatory bowel diseases (IBD), characterized by relapsing intestinal inflammation, chronic fatigue is a burdensome and highly prevalent symptom.
- Trial name
- ENERGIZE-IBD (NCT05657197)
- Testing
- Exercise intervention, Usual care
- Where
- 3 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Rijnstate Hospital
Inflammatory Bowel Diseases
The IBD-FITT Study - Moderate-intensity Exercise for IBD Patients With Moderate Disease Activity
The investigators aim to investigate whether exercise therapy during 12 weeks including a lesson on general healthy lifestyle in adult patients with a moderately active disease is more effective, compared to control patients only…
- Trial name
- IBD-FITT (NCT04816812)
- Testing
- Exercise intervention, Lifestyle - online lesson intervention
- Where
- 2 sites in Denmark
- Volunteers
- 44 people
- Sponsor
- University of Southern Denmark
Inflammatory Bowel Diseases, Crohn Disease
The Mind-Body IBD Study: Understanding the Mind-body Connection in IBD
An aspect of IBD care that is often overlooked is mental health treatment. Common mental health problems, such as anxiety and depression are very common in IBD, with a meta-analysis estimating prevalence as high as 25.2% for…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Crohn Colitis
- Trial name
- NCT06116331
- Testing
- Data collection
- Where
- United Kingdom
- Volunteers
- 170 people
- Sponsor
- King's College London
Secondary Progressive Multiple Sclerosis With Inflammatory Disease Activity
Swiss Study of the Impact of Mayzent on SPMS Patients in a Long-term Non-interventional Study
This study is a national, prospective, multicenter, non-interventional (observational) study with the aim to describe the impact of Siponimod treatment in a real-world SPMS population in Switzerland who are treated with Siponimod…
- Trial name
- SWISSMASIA (NCT04895202)
- Testing
- Siponimod
- Where
- 6 sites in Switzerland
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Axial Spondyloarthritis, Inflammatory Disease
Exercise Therapy in Patients With Axial Spondyloarthritis
Regular exercise, such as brisk walking, has been shown to lower levels of indicators of inflammation in the blood in people with long term conditions. This includes people with heart disease, kidney disease and diabetes.
- Conditions
- Axial Spondyloarthritis, Inflammatory Disease, Arthritis
- Trial name
- ExTASI (NCT04368494)
- Testing
- 12-week home based exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Loughborough University
Inflammatory Bowel Diseases
The Effects of Combined Lifestyle Intervention (CLI) in Patients With Inflammatory Bowel Disease (IBD)
A single-center observational study to investigate the effects of combined lifestyle intervention (CLI, in Dutch: gecombineerde leefstijlinterventie, GLI) in patients with Inflammatory Bowel Disease.
- Trial name
- GLI-IBD (NCT05725369)
- Testing
- Combined Lifestyle Intervention (CLI)
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Ulcerative Colitis, Inflammatory Bowel Diseases
Effects of Exercise in Patients With Ulcerative Colitis
The aim of this study is to investigate the effects of moderate to high intensity exercise on gut function and inflammatory markers in patients with Ulcerative Colitis (UC), and to compare them with individuals of matched age who…
- Trial name
- NCT04143490
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University