Clinical trials: Inflammatory Disorder
Subacromial Impingement Syndrome, Subacromial Bursitis
Subacromial Injection With Corticosteroid Versus Nonsteroidal Anti-inflammatory Drugs (NSAID) in Shoulder Impingement Syndrome
Injection with corticosteroid is one of the most common non-operative interventions in the treatment of subacromial impingement; however, its use is limited by its potential side effects (e.g.
- Trial name
- NSAID (NCT01449448)
- Testing
- Ketorolac, Triamcinolone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Colitis, Ulcerative
A First Time in Human Study to Evaluate the Safety and Tolerability of GSK4381406 in Healthy Participants
This is a 3-part First Time in Human (FTIH) study to evaluate the safety, tolerability, and pharmacokinetics (PK) profile of GSK4381406 following administration of single ascending doses (Part 1), repeat ascending doses (Part 2)…
- Trial name
- NCT05999708
- Testing
- GSK4381406, Indomethacin
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Crohn Disease, Ulcerative Colitis
Endoscopic Ultrasound Determines Disease Activity in Crohn's Disease And Ulcerative Colitis
Although Crohn's disease and ulcerative colitis are the main subtypes of inflammatory bowel disease, they differ substantially in disease behavior, prognosis, and treatment paradigm.
- Trial name
- EUSIBD (NCT03863886)
- Testing
- Endoscopic ultrasound catheter (UM-2R/3R, Olympus)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Acute Respiratory Distress Syndrome, Corona Virus Infection
Knowledge, Attitude and Practice of Dental Students About COVID-19
Coronavirus disease 2019 (abbreviated "COVID- 19") is a pandemic respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China.
- Conditions
- Acute Respiratory Distress Syndrome, Corona Virus Infection, Acute Lung Injury, Fever
- Trial name
- NCT04449081
- Testing
- Knowledge, Attitude, Practice, Awareness, Preference
- Where
- Malaysia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Inflammatory Bowel Diseases, Parkinson Disease
Gut Microbiota Dysbiosis and Translocation During IBD and Parkinson
Inflammatory bowel diseases (IBD) and Parkinson disease (PD) are complex and multifactorial pathologies. Gut microbiota seems to play an active role.
- Trial name
- Medibiote1 (NCT04159727)
- Testing
- stool and blood analysis
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Reversible Pulpitis, Irreversible Pulpitis
Biomarkers for Differentiating Reversible and Irreversible Pulpitis
This observational study aims to evaluate the role of inflammatory, oxidative stress, neurogenic, and immunological biomarkers obtained from pulpal blood in the differential diagnosis of normal pulp, reversible pulpitis, and…
- Conditions
- Reversible Pulpitis, Irreversible Pulpitis, Healthy Pulp
- Trial name
- PULPBIOM (NCT07658742)
- Testing
- Pulpal Blood Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Safa
Ulcerative Colitis
SAD/MAD Study in Healthy Subjects and Adults With UC to Evaluate Safety, Tolerability, PK, PD of AMT-101
A randomized, double-blind placebo-controlled first in human study in approximately 36 male healthy subjects and approximately 20 male and female patients with active UC who have had an inadequate response to or demonstrated…
- Trial name
- AURIGA1 (NCT04224857)
- Testing
- AMT-101
- Where
- 4 sites in Georgia, Germany and 2 more
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Applied Molecular Transport
Gastrointestinal Disorder, Immunologic Diseases in Children
Whole Grain, Gluten-containing Cereal and PROBIOtics to Evaluate Digestive TOLERAance and Immuno-inflammatory Response
This study will assess the development of gastrointestinal health in terms of digestive tolerability and immune-inflammatory response at the intestinal level comparing a conventional gluten-free cereal with a new cereal with…
- Trial name
- PROBIOTOLERA (NCT04021303)
- Testing
- Experimental cereal, Conventional cereal
- Where
- Spain
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Laboratorios Ordesa
Inflammatory Bowel Diseases
Identify Specific Peripheral Blood Mononuclear Cell (PBMC) MiRNA as Biomarkers for Inflammatory Bowel Disease (IBD)
To find high sensitivity and specificity biomarkers to better diagnose and monitor progression of inflammatory bowel disease (IBD).
- Trial name
- NCT04256538
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Periodontitis
Clinical and Anti-inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket
application of 1% curcumin gel in clinical study design will be used . The study will be conducted in Al-Najaf specialised dentistry center.
- Trial name
- NCT04355416
- Testing
- curcumin Oral gel, subgingival scaling and root planing
- Where
- Iraq
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Healthy Infants, Infants With an Inflammatory Condition
Novel Isotope Dilution Technique to Assess Vitamin A Status
Background: There is no reliable method for vitamin A (VA) assessment for infants and young children. Serum VA concentration is not an authenticate indicator of VA status, while existing deuterium- VA isotope dilution methods to…
- Trial name
- NCT03000543
- Testing
- Vaccine
- Where
- 2 sites in Bangladesh
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Aging, Age-Related Memory Disorders
Effects of Blueberry on Cognition and Mobility in Older Adults
This study is being conducted to assess the effect of dietary blueberry supplementation on cognition and mobility in older adults.
- Trial name
- NCT01888848
- Testing
- Freeze-dried Blueberry
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- USDA Human Nutrition Research Center on Aging
Lung Inflammation, Experimental Lung Inflammation
Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air at Rest
The primary purpose of this study is to measure pulmonary function, symptoms, and pulmonary inflammatory responses in healthy young adults during and immediately after exposure to a low concentration of ozone (0.070 ppm) or clean…
- Trial name
- LOCONOZ3 (NCT06943989)
- Testing
- Ozone Exposure, Clean air (0.0 ppm ozone)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Type 2 Diabetes, Healthy
Type 2 Diabetes and the Effect of Probiotics
Insulin-resistance in type 2 diabetes is associated with chronic inflammation. Anti-inflammatory actions might increase sensitivity to insulin.
- Conditions
- Type 2 Diabetes, Healthy, Endotoxemia
- Trial name
- NCT00413348
- Testing
- Lactobacillus acidophilus NCFM
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Periodontitis
Boron Levels, Oxidative Stress, and Inflammation in Periodontitis
This cross-sectional observational study aims to evaluate the relationship between boron levels and oxidative stress, antioxidant defense, and inflammatory markers in individuals with periodontitis.
- Trial name
- NCT07775378
- Testing
- Biochemical Assessment of Saliva and Gingival Tissue
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Fibromyalgia, Rheumatoid Arthritis
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated…
- Trial name
- NCT05277025
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Florida
Metabolic Syndrome, Obesity and Obesity-related Medical Conditions
Effects of Intermittent Fasting and Exercise on Inflammation, Metabolism, and the Microbiome in Metabolic Syndrome
The goal of this intervention trial is to assess the effects of intermittent fasting, both alone and in combination with high-intensity interval training, on patients with obesity and metabolic syndrome.
- Trial name
- FIT (NCT06885255)
- Testing
- Alternate day fasting, Time restricted eating, High-intensity interval training
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammatory Bowel Disease, Colorectal Cancer
Intestinal Microbiota and Colorectal Cancer in Inflammatory Bowel Disease
Build a collection of fecal microbiota in order to determine the characteristics of gut microbiota associated with colorectal cancer in Inflammatory bowel disease (IBD).
- Trial name
- DYSCOLIC (NCT02726243)
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Acute Effects of Different Exercises on Blood Pressure in Hypertensive Subjects
Lifestyle changes might reduce cardiovascular risk due to the decrease in blood pressure (BP). However, whether combining aerobic and resistance exercises affect BP and hemodynamic parameters, as well as arterial stiffness and…
- Trial name
- NCT02987452
- Testing
- aerobic exercise, resistance exercise, combined exercise
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Heitor Moreno Junior
Hypoglycemia, Inflammatory Response
Consequences of Hypoglycaemia on Cardiovascular and Inflammatory Responses
People with Type 1 diabetes (T1DM), type 2 diabetes (T2DM) and healthy volunteers will undergo a hypoglycaemic clamp to to investigate the effect of hypoglycaemia on cardiovascular and inflammatory responses.
- Conditions
- Hypoglycemia, Inflammatory Response, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- HCIR (NCT03976271)
- Testing
- hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
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