Clinical trials: Inflammatory Disorder
Ulcerative Colitis (UC)
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb942 in healthy volunteers (Parts A and B).
- Trial name
- NCT06619990
- Testing
- XmAb942
- Where
- 114 sites in United States, Argentina and 17 more
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.
Crp, Insulin Resistance
The Effect of Oral Whey Consumption on Insulin Resistance, Cortisol, Crp, Albumin Level and Healing Quality Before Total Hip Arthroplasty
Purpose: It was planned to determine the effect of oral whey given before total hip arthroplasty (THA) on postoperative insulin resistance, cortisol, CRP((C reactive protein), albumin level and healing quality.
- Conditions
- Crp, Insulin Resistance, Cortisol; Hypersecretion, Albus; Lichen
- Trial name
- WHEY THA (NCT06307782)
- Testing
- whey protein intake before surgery, Water before surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Ulcerative Colitis
Fecal Microbiota Transplantation (FMT) for Treatment of Ulcerative Colitis in Children
Patients diagnosed with ulcerative colitis (UC), a specific type of inflammatory bowel disease, will be invited to take part in this study. The investigators do not know what causes UC.
- Trial name
- FMT (NCT01947101)
- Testing
- Fecal Microbiota Transplant
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Calprotectin, Inflammatory Bowel Disease
Value of Fecal Calprotectin
For the main goal - the accuracy of calprotectin for the diagnosis of IBD - calprotectin levels will be compared between patients with and without a diagnosis of IBD and the sensitivity, specificity and accuracy will be…
- Trial name
- NCT00577928
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Indiana University
Prediabetes, Obesity & Overweight
Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers.
Numerous plant-based foods contain bioactive compounds, in particular polyphenols, which have antioxidant, anti-inflammatory, and metabolic regulatory effects.
- Conditions
- Prediabetes, Obesity & Overweight, Inflamation, Oxidative Stress
- Trial name
- BIOTRANSFORM (NCT07659028)
- Testing
- supplementation, food
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Rheumatoid Arthritis AND Apical Periodontitis
Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study
SUMMARY TITLE: "Effect of endodontic treatment on inflammatory markers, disease activity and periapical healing in rheumatoid arthritis patients with apical periodontitis" RATIONALE: Chronic inflammation plays a pivotal role in…
- Trial name
- NCT06433232
- Testing
- ROOT CANAL TREATMENT
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Periodontitis
Clinical and Anti-inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket
application of 1% curcumin gel in clinical study design will be used . The study will be conducted in Al-Najaf specialised dentistry center.
- Trial name
- NCT04355416
- Testing
- curcumin Oral gel, subgingival scaling and root planing
- Where
- Iraq
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Correlation Between the Microbiome and Type 2 Inflammatory Diseases of CRSwNP
Nasal microorganisms, exfoliated cells, nasal secretions, fetal microorganisms and blood were collected from patients with chronic sinusitis with nasal polyps before medication.
- Trial name
- NCT06231004
- Testing
- glucocorticosteroid and surgery
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
GBS Rectovaginal Colonization, Neonatal Sepsis
Probiotics and GBS Colonization in Pregnancy
Multicentric, randomized, placebo-controlled, double-blind, parallel group study aimed at evaluating the feasibility and effect of the use of probiotic starting from the 30th week, on vaginal / rectal colonization of GBS in women…
- Trial name
- NCT05156333
- Testing
- Respecta
- Where
- 3 sites in Italy
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Overweight, Obesity
Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men
Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease…
- Conditions
- Overweight, Obesity, Inflammation
- Trial name
- NCT00221052
- Testing
- Diclofenac
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TNO
Ulcerative Colitis, Healthy
Genome Analysis Across Populations in Inflammatory Bowel Disease
Objective: To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD within affected populations.
- Conditions
- Ulcerative Colitis, Healthy, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- NCT06042387
- Testing
- Blood or saliva sample collection
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Inflammatory Disease, Permeability; Increased
Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe
The purpose of this study is to examine the feasibility of using a trans-nasal IPD probe as a measurement tool for gut permeability
- Conditions
- Inflammatory Disease, Permeability; Increased, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- NCT04565821
- Testing
- IPD Probe via TNIT
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2
The Effect of Single Probiotic on Metabolic Control in Type 2 Diabetes
Recent studies indicate that dysbiosis of intestinal microbiota and low grade inflammation are important pathogenic determinants of type 2 diabetes (T2DM), which has increased in epidemic size over the last 20 years.
- Trial name
- NCT05066152
- Testing
- Lactobacillus rhamnosus GG (ATCC 53103)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuropathy With Antibody A MAG
The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a promising growing field (1). Non-invasive and painless, ultrasound provides additional data electroneuromyography (EMG), with a spatial…
- Trial name
- EchoNerf (NCT03008733)
- Testing
- Ultrasound UHF peripheral nerves, Electro myography surface nerves
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Severe Sepsis
Effect of a Sepsis Prediction Algorithm on Clinical Outcomes
In this clinical outcomes analysis, the effect of a machine learning algorithm for severe sepsis prediction on in-hospital mortality, hospital length of stay, and 30-day readmission was evaluated.
- Trial name
- NCT03960203
- Testing
- InSight
- Volunteers
- 75,147 people, healthy volunteers welcome
- Sponsor
- Dascena
Asthma, Dietary Intervention
Vegan Diet and Immune-Inflammatory Outcomes in Asthma and Healthy Adults
This randomized controlled study evaluates the effects of a balanced vegan diet compared with a balanced omnivorous diet on inflammatory and immune response markers and clinical asthma parameters in healthy adults and individuals…
- Conditions
- Asthma, Dietary Intervention, Vegan Diet
- Trial name
- VEGASTHMA (NCT07480369)
- Testing
- Omnivorous diet, Vegan diet
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Skin Infection
Skin Inflammation and PK of Azithromycin
This study will investigate the tissue distribution of azithromycin in healthy, artificially inflamed and actually infected tissue of humans.
- Trial name
- AZI_IMQ_LPS (NCT06170983)
- Testing
- Azithromycin, Biopsy, Skin inflammation model
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Inflammatory Skin Conditions
Multi-Omic SignAtures of Inflammatory Cutaneous Diseases
The goal of this observational study is to identify the immune profile underlying various inflammatory skin diseases, through multi-omic procedures. The main questions it aims to answer are: 1.
- Trial name
- MOSAIC (NCT07771673)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Inflammatory Bowel Disease
Psychobiology in Inflammatory Bowel Disease(IBD)
Patients with ulcerous colitis and Crohn's disease, age 18-60, with a relapse within the last 18 months and an activity index ≥4, with a long time stress level ≥60 on the perceived stress questionnaire (PSQ) were randomized to a…
- Trial name
- INSPIRE (NCT00248742)
- Testing
- Psychological behavioral intervention
- Where
- Norway
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Ulcerative Colitis (UC), Ulcerative Colitis (Disorder)
A Phase I Study to Evaluate the Safety/Tolerability of BDHK-2009 Tablets in Healthy Adult
A Phase 1, 2-part, randomised, double-blind, placebo-controlled, FIH study to determine the safety, tolerability, and PK of single, ascending oral doses (SAD) of BDHK-2009 (Part 1) and multiple oral doses (Part 2) of BDHK-200 in…
- Conditions
- Ulcerative Colitis (UC), Ulcerative Colitis (Disorder), Ulcerative Colitis Acute, IBD (Inflammatory Bowel Disease)
- Trial name
- NCT07632573
- Testing
- BDHK-2009 Tablets
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Benethera (Shaoxing) Biotechnology Co., Ltd.