Clinical trials: Inflammatory Disorder
Colorectal Cancer, Colorectal Adenomas
Double-balloon Colonoscopy to Increase Colonoscopy Completion Rate
The aim of colonoscopy is to visualize the inside of the entire large bowel. Several factors can make the procedure difficult, and sometimes a complete examination is not possible.
- Conditions
- Colorectal Cancer, Colorectal Adenomas, Inflammatory Bowel Disease
- Trial name
- NCT01587872
- Testing
- Fujinon EC-450BI5 double-balloon colonoscope
- Where
- Norway
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Cardiovascular Diseases, Inflammation
Influence of Dietary Nitrate on Skin Inflammation
This study evaluates the potential anti-inflammatory effects of inorganic dietary nitrate in a model of acute inflammation relevant to cardiovascular disease (CVD).
- Conditions
- Cardiovascular Diseases, Inflammation, Inflammation; Skin, Inflammatory Response
- Trial name
- NCT03183830
- Testing
- Nitrate-rich Beetroot Juice, Nitrate-deplete Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Vitamin D Deficiency
Effects of Vitamin D-Enriched Mushrooms on Vitamin D Status and Immune Function and Inflammatory Status in Adults
We propose to assess the effects of including vitamin D-enriched mushrooms as part of participants' usual eating pattern primarily on 25(OH) vitamin D2 status and secondarily on immune function and inflammatory status.
- Trial name
- NCT05559112
- Testing
- Vitamin D-enriched mushrooms, Study Powder
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Purdue University
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Osteoarthritis, Knee
Parabens Flocculation on the Anti Inflammatory Effects of Corticosteroid Injections for Total Knee Arthroplasty
The purpose of this study is to identify whether corticosteroid use with anesthetics containing preservatives (parabens) reduces clinical effectiveness of the anti-inflammatory agent Up to 100 patients, both male and female…
- Trial name
- 5160373 (NCT03445611)
- Testing
- corticosteroid solution with lidocaine containing parabens., corticosteroid solution with lidocaine containing no paraben
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Ulcerative Colitis
Saffron as Anti Inflammatory In Patients With Inflammatory Bowel Disease
Nutritional Saffron supplement has been widely used as food supplement and has known anti-depressant and anti-inflammatory activities. The investigators use saffron extract in Egyptian patients with ulcerative colitis for 8 weeks.
- Trial name
- NCT05715099
- Testing
- Saffron
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Minia University
Preterm Birth, Preterm Labor
Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being
The purpose of this study is to determine whether fluoride supplementation during pregnancy is effective in extending the length of gestation and improving overall perinatal well-being.
- Conditions
- Preterm Birth, Preterm Labor, Bacteremia, Preterm Premature Rupture of Fetal Membranes
- Trial name
- NCT02536352
- Testing
- Prenatal vitamin-mineral containing 3 mg fluoride, Prenatal vitamin-mineral containing 0 mg fluoride
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Inflammatory Bowel Diseases Weight Changes
Weight and BMI Patterns in Biological Based IBD Patients and Its Finacial Impact
Primary Objective To determine the pattern of weight and body mass index (BMI) changes in biologic-treated patients with inflammatory bowel disease (IBD).
- Trial name
- obesity/IFX (NCT07495800)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Metabolic Syndrome X
High Density Lipoprotein (HDL) Functionality in Metabolic Syndrome
The aim of the study is to examine the kinetic, anti-oxidant, anti-inflammatory and cellular cholesterol efflux properties of high-density lipoprotein (HDL) in subjects with the metabolic syndrome (MetS) and lean individuals.
- Trial name
- NCT00716300
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Western Australia
Crohn's Disease, Inflammatory Bowel Disease
A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Techniques
Postoperative pain can pose significant challenges in the postoperative recovery of patients undergoing major colorectal surgery. Traditionally, opioids have played an important role in treating postoperative pain.
- Conditions
- Crohn's Disease, Inflammatory Bowel Disease, Postoperative Pain
- Trial name
- NCT02538679
- Testing
- US TAP Bupivacaine/Epinephrine, Lap TAP Bupivacaine/Epinephrine
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Ulcerative Colitis
Combined Microbiota and Metabolic Signature in Ulcerative Colitis Predicts Anti-Inflammatory Therapy Success
The primary goal of the study is to develop an early (within 4 weeks) combined microbiota/metabolic signature predicting clinical response upon anti-inflammatory treatment in UC patients.
- Trial name
- COMMIT (NCT05702879)
- Testing
- Ozanimod, TNF Inhibitor, Steroids
- Where
- Switzerland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Inflammatory Bowel Diseases (IBD)
Epidemiological Evaluation Of Chronic Kidney Disease In Pediatric Patients With Inflammatory Bowel Disease
This multicenter observational cross-sectional study aims to evaluate the prevalence of chronic kidney disease (CKD) in pediatric patients with inflammatory bowel disease (IBD) and to compare it with a control group without IBD.
- Trial name
- KIBD (NCT07670988)
- Testing
- Clinical and Laboratory Data Collection
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Rheumatoid Arthritis, Osteoarthritis
FolateScan in Autoimmune Disease
This study will gather information on the safety of FolateScan and the ability of FolateScan to detect inflammation in the joints and other organs in people with arthritis (rheumatoid arthritis and osteoarthritis), systemic lupus…
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Multiple Sclerosis, Crohn's Disease
- Trial name
- NCT00588393
- Testing
- FolateScan (Technetium Tc 99mEC20)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gingival Recession
Evaluation of the Inflammatory and Healing Profile After Root Coverage With Emdogain®
The purpose of this study was the evaluation of inflammatory and healing profile after root coverage using of Enamel Matrix Derivative.
- Trial name
- NCT03059966
- Testing
- Microsurgery technique for root coverage, Microsurgery technique for root coverage associated to EMD
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Osteoarthritis, Knee
Combination of Curcuminoid With Acupressure for Inflammation and Pain in the Elderly With Osteoarthritis Genu
The goal of this clinical trial is to to investigate the efficacy of acupressure and standardized curcuminoids from turmeric extract to inflammatory markers, endorphin hormones in the blood and quality of life in elderly patient…
- Trial name
- NCT06105840
- Testing
- Acupressure and Standardized Curcuminoid from Turmeric Extract
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Ulcerative Colitis
Utility of Low Intensity Pulsed Ultrasound Stimulation (LIPUS) to Modulate the Release of Mediators Capable of Reflecting the Inflammatory State in the Affected Colonic Tract of Ulcerative Colitis Patients
The goal of this clinical trial is to learn whether Low Intensity Pulsed Ultrasound (LIPUS) is capable of promoting the release of extracellular vesicles from the gut into the bloodstream of Ulcerative Colitis (UC) patients…
- Trial name
- LIPUSinVIVO (NCT06569888)
- Testing
- LIPUS stimulation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Diabetes Mellitus, Type 1, Inflammation
The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-II
The goal of this trial is to study the effect that adrenaline has on the immune reaction seen during a low blood sugar. People with type 1 diabetes do not produce their own insulin.
- Trial name
- RAID-II (NCT06422494)
- Testing
- hyperinsulinaemic hypoglycaemic clamp, Propranolol Hydrochloride 1 MG/ML, Phentolamine
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Inflammatory Bowel Disease
Analysis of Birth Outcomes of Swedish, Danish and Finnish Women Exposed to Remicade With Inflammatory Bowel Disease, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Psoriasis
The purpose of this study is collection and analysis of information pertaining to pregnancy outcomes in women exposed to infliximab during pregnancy, relative to the background risk in similar but non-biologic exposed patients…
- Trial name
- NCT00658827
- Testing
- No intervention
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Janssen Biotech, Inc.
Power, Metabolic Disturbance
Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists
This clinical study evaluates the effect of 500 mg of 2S-hesperidin for 8 weeks on performance (power generated in different metabolic zones), body composition (fat and muscle mass) and biochemical (antioxidant, inflammatory…
- Conditions
- Power, Metabolic Disturbance, Change, Body Weight, Changes Fatty
- Trial name
- HESPERFORMAN (NCT04597983)
- Testing
- 2S-hesperidin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Muscular Atrophy
Two Weeks of Reduced Activity and Skeletal Muscle Health in Older Men
Muscle size declines at around 0.5-1% per year after 50 years of age, with muscle strength declining up to twice as fast as muscle size.
- Trial name
- NCT02495727
- Testing
- Step-reduction, Pre-training, Exercise snacking
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Bath
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