Clinical trials: Inflammatory Disorder
Pre-Eclampsia
Preeclamptic Patients and Pentraxin 3 & Lipoprotein-associated Phospholipase A2
In particular, pentraxine 3 (PTX3) molecule was assumed to have a prognostic value in acute myocardial infarction.In patients affected by acute myocardial infarction, early plasma elevation of PTX3 appears to predict a worse…
- Trial name
- NCT04239352
- Testing
- Pentraxin 3 ; new biomarker, Lipoprotein-associated phospholipase A2 ; new biomarker
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Hemolytic Disease of Newborn, Anemia of Neonates
Risk Factors and Clinical Outcomes of Neonatal Anemia in NICU
Risk Factors, and Clinical Outcomes of Neonatal Anemia in the NICU of a Tertiary Care Hospital
- Conditions
- Hemolytic Disease of Newborn, Anemia of Neonates, Sepsis
- Trial name
- NCT07188298
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pre-Eclampsia, Pre-Term
Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes
Women who had an adverse pregnancy outcome (APO), such as preeclampsia, preterm birth, or gestational diabetes, have a higher risk for heart disease.
- Conditions
- Pre-Eclampsia, Pre-Term, Intrauterine Growth Restriction, Hypertension in Pregnancy
- Trial name
- VIA (NCT04633551)
- Testing
- Anti-inflammatory supplement
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Ulcerative Colitis
Study for Safety and Tolerability of TOP1288 Administered Rectally in Healthy and Ulcerative Colitis Subjects
This study evaluates the safety and tolerability of TOP1288 rectal single and multiple ascending doses in healthy subjects and multiple doses in subjects with ulcerative colitis.
- Trial name
- NCT02463045
- Testing
- TOP1288
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Topivert Pharma Ltd
Tympanic Membrane Perforation
Insulin Intratympanic Application
The objective of the present study was to study the impact of insulin insitu-gel formulation on healing progress after surgical procedures for treatment of dry tympanic membrane perforation for at least three consecutive months.
- Trial name
- NCT07535827
- Testing
- Insulin (Humulin), foam
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Deraya University
Inflammatory Bowel Diseases
Can we Rely on HLA to Predict Resistance to Biological Therapy in IBD Patients
The investigators propose an observational study including patients with inflammatory bowel disease under biological therapy with anti-TNF, anti-integrin α₄β₇ or anti-interleukin 12-23 (Ustekinumab), followed by an external…
- Trial name
- NCT05040854
- Testing
- HLA-DQA1*05 and DRB1
- Where
- Portugal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Tondela-Viseu
Pain, Neuropathic, Pain, Inflammatory
Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers
Phase I Part 1 (single ascending dose): Double-blind dosing will occur in healthy volunteers in 4 cohorts of 8 subjects each. Six subjects in each cohort will be randomized to receive AFA-281 and 2 subjects will be randomized to…
- Trial name
- NCT05547503
- Testing
- AFA-281
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Healthy
Serum Insulin Response After Acute and Chronic Sucralose Ingestion in Healthy Volunteers With Variable Body Mass Index
The consumption of non-caloric sweeteners has increased worldwide; Current publications suggest its consumption associates to insulin resistance.
- Trial name
- NCT03703141
- Testing
- sucralose 48 mg (splenda)/day for ten weeks
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Plaque Induced Gingival Disease, Oral Health
Effect of Benzydamine Hydrochloride Mouthrinse on Plaque Accumulation in Periodontally Healthy Female Subjects
The goal of this clinical trial is to evaluate the effect of a mouthrinse containing an active ingredient benzydamine hydrochloride in the absence of daily oral hygiene.
- Trial name
- BHCl-PLAQUE (NCT07565766)
- Testing
- Benzydamine hydrochloride mouthrinse
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Intrauterine Growth Restriction
Study of the Fetal and Maternal Microbiota in Preganant Women With Fetal Defect Growth
It is an observational and prospective study that will include consecutively 63 controls (fetuses with estimated fetal weight above the 10th centile) and 63 fetuses with defects in fetal growth (estimated fetal weight below the…
- Trial name
- BIOCIR (NCT04047966)
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Inflammation, Chronic Kidney Disease
Role of Prohepcidin in Uremic Patients
The investigators aimed to study the effect of prohepcidin levels on hematologic parameters and inflammatory markers in non-diabetic uremic patients.
- Trial name
- NCT01735773
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Guillain Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Our Study Aims to Determine if Nerve Alterations in Acute GBS and CIDP Detectable by Ultrasound Match Electrodiagnostic Findings and if This Method Aids Early Diagnosis, Predict Their Outcomes and Differentiate Between Axonal and Demyelinating Subtypes.
Neuromuscular ultrasound (NMUS) is emerging as a valuable non-invasive diagnostic tool. In GBS, NMUS can detect proximal nerve enlargement early, before neurophysiological changes.
- Conditions
- Guillain Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Peripheral Nerve Disorder, Peripheral Nerves US
- Trial name
- NCT06615622
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infant, Newborn, Diseases, Sepsis
Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn
The purpose of this study is to evaluate whether use of the disinfectant chlorhexidine administered to the birth canal during labour and newborn at delivery can protect a woman and her baby from bacterial infections after birth.
- Conditions
- Infant, Newborn, Diseases, Sepsis, Puerperal Infection
- Trial name
- NCT00136370
- Testing
- Chlorhexidine, Birth canal wipe, sterile water external genital wipe
- Where
- South Africa
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Crohn Disease, Ulcerative Colitis
Multi-omics to Predict Responses to Biologics in IBD
Inflammatory bowel disease (IBD) is a chronic immune-related disease, which mainly affects the digestive tract. There are mainly two forms of the disease, including Crohn's disease (CD) and ulcerative colitis (UC).
- Trial name
- MORE (NCT05542459)
- Testing
- Biologics
- Where
- China
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn Disease
The Associations of Plasminogen Activator Inhibitor-1 Gene Polymorphisms With Crohn's Disease in Chinese Patients
From January 2020 to January 2025, Crohn's disease (CD) patients and gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT06935942
- Testing
- Ustekinumab - Standard Dosage
- Where
- China
- Volunteers
- 906 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Infections, Vector Borne Diseases
Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum
This is an open-label, adaptive study using the P. falciparum induced blood stage malaria (IBSM) model to characterise the pharmacokinetic/pharmacodynamic (PK/PD) profile and safety of MMV367 (the IMP).
- Conditions
- Infections, Vector Borne Diseases, Systemic Inflammatory Response Syndrome, Inflammation
- Trial name
- NCT05979207
- Testing
- MMV367 3mg, P. falciparum IBSM infection, MMV367 5mg
- Where
- 2 sites in Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Peripheral Neuropathic Pain
Gabapentin and Pregabalin Effects on Inflammation and Cardiac Function in Peripheral Neuropathic Pain
This prospective, controlled, observational cohort study will evaluate short-term changes in inflammatory biomarkers and subclinical cardiac function in adults with peripheral neuropathic pain who are prescribed gabapentin or…
- Trial name
- NCT07755514
- Testing
- Gabapentin, Pregabalin
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Giresun University
Sepsis, Necrotizing Enterocolitis
Circulating Markers in Preterm Infants With Perinatal and Neonatal Inflammation
Circulating markers to diagnose complications (sepsis, necrotizing enterocolitis) in preterm infants are often inaccurate, partly due to the lack of comprehensive studies with temporal evaluation from birth until a disease onset.
- Conditions
- Sepsis, Necrotizing Enterocolitis, Chorioamnionitis, Feeding Intolerance
- Trial name
- NEOINFLAM (NCT03320785)
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Per Torp Sangild
Obstructive Sleep Apnea
The Study of Skeletal Muscle Function in Obstructive Sleep Apnea
The purposes of this study includes (1)to investigate inspiratory muscles and non-inspiratory muscle function in terms of strength, endurance, and fatigability in patients with obstructive sleep apnea (OSA), (2) investigate the…
- Trial name
- NCT00813852
- Testing
- exercise training, IMT
- Where
- Taiwan
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Periodontal Disease, Systemic Inflammatory Markers
Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers
This is a single center, double blinded, randomized, controlled trial. Qualified subjects will be enrolled and randomized to either one of the two study groups: a) using 0.3% triclosan/copolymer/fluoride dentifrice twice daily …
- Trial name
- NCT02670135
- Testing
- Triclosan Containing Toothpaste, Triclosan Free Toothpaste
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
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