Clinical trials: Inflammatory Disorder
Malaria
Impact of Antimalarial Treatment on Measures of T Cell Suppression/Regulation in Healthy Adults From Doneguebougou, Mali
Background: Malaria is a disease that affects many people in the country of Mali and other parts of Africa. It is caused by germs that are spread by mosquito bites.
- Trial name
- NCT02659566
- Where
- Mali
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Monitor Acne Lessions Count Reduction as Result of Usinfg the Device
Clinical and Usability Study to Determine Safety and Efficacy of the Clear Device for Acne Treatment
This is a clinical research study to determine the ability of the Clear device to treat mild to moderate inflammatory acne, and to determine if the average person is able to use the device properly according to the labeling as…
- Trial name
- NCT01678482
- Testing
- light based device for treatment of acne
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Alzheimer's Disease
BONSAI: Biomarkers of Nonsteroidal Anti-Inflammatories
The purpose of this study is to test the effect of ibuprofen on the levels of a number of different proteins (called biomarkers) in cerebrospinal fluid (CSF), blood, and urine to see whether ibuprofen can influence certain…
- Trial name
- NCT00239746
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Inflammatory Bowel Diseases
Phenotypic Characteristics of Inflammatory Bowel Disease in Southeast Asian Population - A Multi-centered US Study
This is a retrospective, case control study of inflammatory bowel disease. This study will analyze the phenotypic characteristics of inflammatory bowel disease in the Southeast Asian population and will help describe clinical…
- Trial name
- NCT00573846
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Crohn's Disease, Inflammatory Bowel Disease
Corticosteroid Dosage for Crohn's Disease Flare
Prospective randomized comparative effectiveness trial designed to compare fixed dosing and weight-based dosing of corticosteroids in patients with Crohn's disease flares.
- Trial name
- NCT02392286
- Testing
- Corticosteroid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
Asthma
Study of ARO-RAGE in Healthy Subjects and Patients With Inflammatory Lung Disease
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of ARO-RAGE in normal healthy volunteers (NHVs) and in participants with inflammatory lung disease (asthma).
- Trial name
- NCT05276570
- Testing
- ARO-RAGE
- Where
- 8 sites in Australia, New Zealand and 3 more
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals
Autoimmune and Chronic Inflammatory Diseases
A Study to Investigate the Pharmacokinetics and Safety of Remibrutinib in Participants With Severe Renal Impairment Compared to Matched Healthy Participants.
The purpose of this study is to support the development of remibrutinib dosing recommendations for patients with impaired renal function.
- Trial name
- NCT07032272
- Testing
- remibrutinib
- Where
- 4 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Osteo Arthritis Knee, Arthritis
Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis
The purpose of this study is to measure the effectiveness of Sustained Acoustic Medicine (SAM) treatment combined with diclofenac ultrasound coupling gel in patients with stage II and stage III knee osteoarthritis.
- Trial name
- SAM (NCT04391842)
- Testing
- Sustained Acoustic Device with 1% Diclofenac patch
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Obstructive Sleep Apnea, Sleep Apnea
Inflammation and Neurocognitive Damage Markers in Elderly People With Obstructive Sleep Apnea
The aging process tends to promote an overall increase in inflammation compromising the immunologic system regulation, sleep/wakefulness pattern, and neurocognitive performance.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Apnea, Obstructive, Obstructive Sleep Apnea Syndrome
- Trial name
- NCT04882020
- Testing
- cortisol, BDNF, s100B, IL-1B, IL-6, IL-10, TNF-alpha
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Sleep Disturbance, Fatigue
Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease
The purpose of this study is to determine if either a targeted type of talk therapy (Phase I) or medication, Wellbutrin, (Phase II) improve sleep disturbance and/or fatigue in individuals with Inflammatory Bowel Disease (IBD).
- Conditions
- Sleep Disturbance, Fatigue, Inflammatory Bowel Disease
- Trial name
- NCT02162862
- Testing
- Behavioral Counseling, bupropion-SR
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Eva Szigethy
Neonatal Sepsis
Using Machine Learning to Model Early-onset Neonatal Sepsis Risk in Uganda and Zimbabwe
The goal of this observational study is to develop a risk prediction model for early-onset neonatal sepsis in term and late preterm neonates in Uganda and Zimbabwe.
- Trial name
- NeoRisk (NCT06411405)
- Testing
- Maternal medical history
- Where
- 2 sites in Uganda, United Kingdom
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Inflammatory Bowel Diseases, Ulcerative Colitis
Personalized B-fructan Diet in Inflammatory Bowel Disease Patients
This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our…
- Trial name
- NCT05615779
- Testing
- Randomized B-fructan diet, Personalized pectin diet, Personalized B-fructan diet
- Where
- 2 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
NAFLD, MASLD
Determination of Biological Activity of Enriched Serum Following TOTUM-448 Consumption
Dietary intakes of saturated fatty acids remain well above nutritional recommendations for most European countries. This may progressively lead to a pro-inflammatory context and the alteration of lipid metabolism in the liver.
- Conditions
- NAFLD, MASLD, Mild Inflammatory Context
- Trial name
- CnC-TOTUM448 (NCT06047847)
- Testing
- TOTUM-448
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Ulcerative Colitis, Colon Cancer
Study of Effects of L-Arginine in Colitis and Colon Cancer
The purpose of this study is to look at the importance of L-Arginine in the digestive tract. L-Arginine is an amino acid and is important in making proteins within the cell.
- Trial name
- NCT01091558
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Acute Appendicitis
Clinical Diagnosis of Acute Appendicitis with Normal WBCS Count with Role of Inflammatory Markers and Radiology
The aim of this study is to describe the proportion of pa-tients with normal preoperative inflammatorymarkers among patients with histopathologically proven acute appendicitis
- Trial name
- NCT06834958
- Testing
- Appendectomy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post Inflammatory Hyperpigmentation
The Efficacy of Bakuchiol in Treating PIH
Post-inflammatory hyperpigmentation (PIH) is an acquired hyper melanosis that occurs after cutaneous inflammation or injury frequently affecting darker skinned individuals.
- Trial name
- NCT06833996
- Testing
- Bakuchiol, Vehicle
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Atherosclerosis, Leukocyte Activation Disorder
Inflammatory Aspects of Glucose in Hyperlipidemia and Diabetes
In this study, we will investigate both inflammatory systems in healthy volunteers and patients with T2DM on insulin therapy and hyperlipidemia (both familial hyperlipidemia (FH) and familial combined hyperlipidemia (FCH)) during…
- Conditions
- Atherosclerosis, Leukocyte Activation Disorder, Type 2 Diabetes Mellitus, Familial Combined Hyperlipidemia
- Trial name
- INFORM (NCT02130505)
- Testing
- OGTT
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Sint Franciscus Gasthuis
Asthma
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation.
- Trial name
- NCT00595491
- Testing
- Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage
- Where
- United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Benjamin Medoff
Hypertension
Evaluating the Relationship Between Inflammation, Genetics, and Stress in the Development of High Blood Pressure
High blood pressure affects nearly one third of all individuals in the United States. If left untreated, it can lead to stroke, heart failure, heart attack, kidney failure, or blindness.
- Trial name
- NCT00384241
- Testing
- Induced Stress, Buccal Swab
- Where
- United States
- Volunteers
- 1,099 people, healthy volunteers welcome
- Sponsor
- Augusta University
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