Clinical trials: Inflammatory Disorder
Vestibular Disorder, Headache
The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury
Test the hypothesis that a certain set of osteopathic manipulation procedures preformed on patients with mild to moderate traumatic brain injury will result in accelerated rates of recovery assessed using vestibular function…
- Conditions
- Vestibular Disorder, Headache, Traumatic Brain Injury
- Trial name
- NCT03163901
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Inflammatory Bowel Disease (IBD)
A Phase 1 Study of PVT401 in Healthy Subjects
The goal of this clinical trial is to learn what happens to PVT401 when it enters the human body and how it affects the immune system.
- Trial name
- NCT07423000
- Testing
- PVT401, Normal Saline (0.9% NaCl)
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Parvus Therapeutics, Inc.
Acute Lung Injury (ALI) Associated With COVID-19, Inflammatory Lung Conditions Associated With COVID-19
First in Human SAD and MAD Study of Inhaled TD-0903, a Potential Treatment for ALI Associated With COVID-19
This is a phase 1 study in healthy subjects to evaluate the safety, tolerability and pharmacokinetics of single (Part A and B) and multiple (Part B) doses of inhaled TD-0903.
- Trial name
- NCT04350736
- Testing
- TD-0903
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Endometritis Postpartum, Endometritis
Antibiotic Prophylaxis in Ragged Placental Membranes
In some centres, women are routinely given a course of antibiotics postnatally if ragged placental membranes were present at delivery. The investigators examined the necessity such an intervention.
- Conditions
- Endometritis Postpartum, Endometritis, Membranes; Retained
- Trial name
- NCT03459599
- Testing
- Prophylactic antibiotics, No prophylaxis (Amox-clav withheld)
- Volunteers
- 716 people, healthy volunteers welcome
- Sponsor
- Sarawak General Hospital
Severe Sepsis, Critical Illness
Ultrasound Measurement of Reactive Hyperemia in Critical Care
The investigators hypothesize that doctors and nurses can undergo a brief period of training and then use ultrasound to accurately measure blood flow in a forearm artery after a brief period when this flow is interrupted with a…
- Trial name
- URHC (NCT01726595)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Vitamin D Deficiency
Effects of Vitamin D-Enriched Mushrooms on Vitamin D Status and Immune Function and Inflammatory Status in Adults
We propose to assess the effects of including vitamin D-enriched mushrooms as part of participants' usual eating pattern primarily on 25(OH) vitamin D2 status and secondarily on immune function and inflammatory status.
- Trial name
- NCT05559112
- Testing
- Vitamin D-enriched mushrooms, Study Powder
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Purdue University
Interstitial Lung Diseases, Sarcoidosis
The Occurence of Inflammation and Oxidative Stress in Lung Diseases
Reactive oxygen species (ROS) are suggested to play a pivotal role in ILD. Little is known, however, about the endogenous antioxidant levels in ILD that can offer protection against ROS.
- Conditions
- Interstitial Lung Diseases, Sarcoidosis, Idiopathic Pulmonary Fibrosis, COPD
- Trial name
- NCT00512967
- Where
- Netherlands
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Atopic Dermatitis, Acne Rosacea
Inflammatory Cells From Various Pathologies
The objective of this experiment is to develop and validate in vitro methods to isolate inflammatory cells from skin biopsies for quantitative flow cytometry analysis.
- Conditions
- Atopic Dermatitis, Acne Rosacea, Acne Vulgaris
- Trial name
- NCT02270411
- Where
- Canada
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Innovaderm Research Inc.
Endometritis
The Optimal Time for Intravenous Antibiotic Prophylaxis in Elective Cesarean Section
Objective: To determine the optimal time for intravenous antibiotic prophylaxis administration in pregnant women undergoing elective cesarean section to minimize postpartum infectious complication for both the mother \& neonate.
- Trial name
- NCT02742948
- Testing
- ceftriaxone
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
Ex Vivo Comparison Of Combination Versus Single Therapeutic Pathway Inhibition In Human Intestinal Mucosa From Patients With Inflammatory Bowel Disease
The purpose of this study is to evaluate whether simultaneously targeting three inflammatory pathways (TL1A, IL-23, and α4β7) produces a stronger anti-inflammatory effect in intestinal tissue from patients with Inflammatory Bowel…
- Conditions
- Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease), Crohn Disease (CD)
- Trial name
- NCT07824726
- Testing
- Collection of 8 additional intestinal mucosal biopsies during standard-of-care endoscopy for subsequent ex vivo testing, Collection of an additional 2 mL blood sample
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PhoenixLAB srls
Hip Osteoarthritis, Hip Arthritis
Postural Control in Degenerative and Inflammatory Diseases of the Hip
Patients with primary hip osteoarthritis (OA group) and patients with inflammatory hip disease (RA group) and healthy subjects (control group) are enrolled in the study.
- Trial name
- PCHOAI (NCT03783806)
- Testing
- Posturography measurements
- Where
- Hungary
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Szeged University
Postural Orthostatic Tachycardia Syndrome
Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome
In this pilot study, the investigators will test the hypothesis that patients with postural tachycardia syndrome will have an elevated percentage of functional antibodies to adrenergic receptors compared with control subjects…
- Trial name
- NCT02196376
- Testing
- History, Physical, blood draw
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Ankylosing Spondylitis, Rheumatic Arthritis
Biomarkers in Inflammatory Rheumatic Diseases Diagnosis
Ankylosing spondylitis (AS), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are three diseases where early diagnosis remains a major challenge.
- Conditions
- Ankylosing Spondylitis, Rheumatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- BIRDD (NCT06778343)
- Where
- Portugal
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Overweight and Obesity
The Effects of Flaxseed Supplement on Weight and Biochemical Factors in Overweight and Obese Subject
To study the effects of Flaxseed supplement on weight, lipid profile and inflammatory factors in subjects with over weight and obesity, 50 patients will be randomly allocated to receive placebo or 30 grams milled Flaxseed for 12…
- Trial name
- NCT02410668
- Testing
- flaxseed, Exercise recommendation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Nutrition and Food Technology Institute
Inflammatory Disease
A First-in-Human Study of Single and Multiple Doses of Amilo-5MER in Healthy Subjects
This is a three-part, single Centre, double-blind, randomized, placebo-controlled first-in-human study of single ascending doses (SADs, Part 1) and multiple doses (Part 2) of amilo-5MER in healthy young adult male subjects and a…
- Trial name
- NCT05857215
- Testing
- amilo-5MER
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Galmed Pharmaceuticals Ltd
Intermittent Explosive Disorder
Inflammatory Challenge in Human Aggression.
The goal of this clinical trial is to explore the differences in behavioral and cytokine response to a low dose infusion of endotoxin (vs.
- Trial name
- LPSS (NCT06665074)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Inflammatory Bowel Disease 1
Endoscopic Severity Image Recognition to Advance Research and Training in Inflammatory Bowel Disease (EVEREST - IBD)
To develop and train a convolutional neural network to detect and characterize disease severity of inflammatory bowel disease during endoscopy
- Trial name
- NCT04867408
- Where
- United Kingdom
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Obesity
Effect of Resistance Training on Microvascular, Hemodynamic and Physical Parameters in Obese Adolescents
The purpose of this study is to investigate the effect os resistance training on microvascular reactivity, endothelial functions, inflammatory markers, blood pressure, heart rate, body composition and physical fitness in obese…
- Trial name
- NCT01692314
- Testing
- Resistance training
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Neonatal SEPSIS
Epidemiology of Neonatal Sepsis in Neonatal Intensive Care Unit in Assiut University Children Hospital
Neonatal sepsis is an important cause of morbidity and mortality in the pediatric age group . It is one of the leading causes of death in the first 28 days of life both in the developed and developing countries.
- Trial name
- NCT03354650
- Testing
- blood culture
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cognitive Impairment, Functional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging (fMRI) of Brain in ICU Survivors With Cognitive Impairment
Long-term cognitive dysfunction greatly influences patient's quality of life after critical illness. However,its neurophysiological basis remains unknown.This is a 3 year fMRI study conducted at the Jiangyin people's Hospital.
- Conditions
- Cognitive Impairment, Functional Magnetic Resonance Imaging, Septic Shock, Inflammation
- Trial name
- NCT03946839
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jian-jun Yang
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