Clinical trials: Inflammatory Disorder
Healthy Participants
Study to Evaluate the Pharmacokinetics (Movement of Drugs Within the Body), Safety and Tolerability of Brazikumab in Healthy Chinese and White Participants
This is a Phase I, single-centre, open-label, parallel-group, single dose study to evaluate the pharmacokinetics, safety and tolerability of Brazikumab in healthy male and female Chinese participants and healthy male and female…
- Trial name
- NCT05033431
- Testing
- Brazikumab
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Inflammatory Bowel Disease (IBD)
Phase I Study of QLS1510 Tablets in Healthy Participants
This is a Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QLS1510 in Healthy participants
- Trial name
- NCT07760077
- Testing
- QLS1510 Tablets
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Qilu Pharmaceutical Research and Development Center LTD
Drug-Related Side Effects and Adverse Reactions
CYP4A11 and CYP4F2 Gene Variants as Makers of Cardiovascular Adverse Events of Non-steroidal Anti-inflammatory Drugs
Randomized, double-blinded, cross-over and placebo controlled clinical trial to evaluate the association between genetic polymorphism of CYP4F2 with cardiovascular adverse effects of non-steroidal anti-inflammatory drugs…
- Trial name
- NCT02779530
- Testing
- Diclofenac
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eduardo Barbosa Coelho
Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Postoperative Cognitive Decline, Inflammation, and Plasma Levels of Beta-amyloids
Postoperative cognitive dysfunction (POCD) can be a serious complication. The development of therapeutic strategies for the prevention and treatment of this condition requires the identification of subgroup of patients with the…
- Trial name
- NCT00850928
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Breast Cancer, Colo-rectal Cancer
The French E3N Prospective Cohort Study
The French E3N cohort was initiated in 1990 to investigate the risk factors associated with cancer and other major non-communicable diseases in women.
- Conditions
- Breast Cancer, Colo-rectal Cancer, Parkinson Disease, Asthma
- Trial name
- E3N (NCT03285230)
- Where
- France
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Ulcerative Colitis (UC)
Impact of the Novel UC-TREAT Diet on the Gut Microbiome and Its Acceptability in Healthy Adults and Adults With Quiescent Ulcerative Colitis
This will be an open-label dietary intervention study recruiting both healthy adults (≥16y) and adults with quiescent Ulcerative Colitis (UC).
- Trial name
- UC-TREAT (NCT06998277)
- Testing
- Dietary therapy
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
CD - Crohn's Disease
Intestinal Response Patterns to Microbial Signals
A cohort of CD patients (total n=300) and a cohort of controls (healthy individuals and family members of CD patients, total n=200) will be recruited.
- Trial name
- NCT03872622
- Testing
- Blood tests, intestinal biopsies, stool samples, environmental exposure questionnaire and FFQ questionnaire
- Where
- Israel
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
HLH, Hemophagocytic Lymphohistiocytoses
Prospective Validation of the OHI Index
Hemophagocytic lymphohistiocytosis (HLH) associated with hematologic malignancies (HM-HLH) is a syndrome with an abysmal prognosis (10-30% 5 years overall survival).
- Conditions
- HLH, Hemophagocytic Lymphohistiocytoses, Hemophagocytic Syndrome, Hematologic Malignancy
- Trial name
- HLH (NCT05882175)
- Where
- 2 sites in Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Asthma
Asthma/Steroid Withdrawal Study
The investigators propose to study the patterns of metabolite changes in subjects with asthma to determine if there is a predictable pattern prior to, and post, clinical exacerbation. Hypothesis: 1.
- Trial name
- NCT00395239
- Testing
- inhaled corticosteroid
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Atherosclerosis
Preventive Arterial Wall Phenotype and Low-dose Fluvastatin/Valsartan Combination
The study was designed to test whether short-term treatment with a very low-dose combination of fluvastatin and valsartan could induce improvement of endothelial function, arterial stiffness, vascular inflammation, oxidative…
- Trial name
- AGE-ZT (NCT03393377)
- Testing
- fluvastatin 10 mg and valsartan 20 mg
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Acute Kidney Injury, Sepsis
Continuous Renal Replacement Therapy With Oxiris in Acute Kidney Injury and Sepsis
It is an epidemiology study to explore outcomes in patients with acute kidney injury (AKI) and sepsis submitted to continuous renal replacement therapy (CRRT) with Oxiris™.
- Trial name
- NCT06253377
- Testing
- Adsorption membrane filter Oxiris™
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nefro Consultoria de Doenças Renais Ltda
Neonatal Sepsis
Use of Probiotics to Reduce Infections, Death and ESBL Colonisation
This study examines the effect of oral probiotic treatment to newborns on preventing hospitalizations, death and colonization with Extended-spectrum beta-lactamase-producing Gram negative bacteria.
- Trial name
- ProRIDE (NCT04172012)
- Testing
- Labinic (R) probiotic mixture
- Where
- Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Haydom Lutheran Hospital
Ankylosing Spondylitis, Psoriasis
Evaluation of Serum IL-41 Level in Patients With Ankylosing Spondylitis and Psoriatic Arthritis
Psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are chronic inflammatory diseases within the spectrum of spondyloarthritis, characterized by immune-mediated inflammation and progressive functional impairment.
- Trial name
- NCT07648836
- Testing
- IL 41
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Endometritis
Uterine Flora During Elective and Urgent Cesarean Sections
Hypothesis: The bacterial flora of the uterus during elective Cesarean sections differs from the uterine flora during non-elective Cesarean sections.
- Trial name
- NCT00500019
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Bronchial Asthma
Study on the Correlation Between TCM Syndrome, Inflammatory Phenotype and Biomarker of Bronchial Asthma
This study aims to determine the TCM syndrome pattern and the distribution of inflammation phenotype in different stages of bronchial asthma; to explore the correlation between TCM syndrome and inflammation phenotype.
- Trial name
- NCT04128111
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Henan University of Traditional Chinese Medicine
Lymphoma
Serum Protein Patterns in Participants With Mycosis Fungoides/Cutaneous T-Cell Lymphoma, Psoriasis, or Normal Skin
RATIONALE: The presence of specific serum proteins may allow a doctor to determine if a patient has mycosis fungoides/cutaneous T-cell lymphoma.
- Trial name
- NCT00066664
- Testing
- proteomic profiling
- Where
- 4 sites in United States
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Ulcerative Colitis
TP0502-B-Pharmaco-Scintigraphic-Study
This is a Phase I, open-label, single-site trial to evaluate the drug release, using scintigraphic images and mesalazine plasma levels (PK) in healthy subjects. Overall, nine [9] subjects will be evaluated.
- Trial name
- NCT02306798
- Testing
- TP05
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Tillotts Pharma AG
Diabetes Mellitus, Type 2, Insulin Resistance
Efficacy of NOSHINtrial in Diabetic Patients
The goal of this [Efficacy of a traditional anti-diabetic herbal drug with on glycemic, inflammatory, and oxidative stress parameters] is [investigate the level of HOMA-estimated insulin resistance as the primary outcome before…
- Trial name
- NOSHIN (NCT06205030)
- Testing
- anti-diabetic herbal drug
- Where
- Iran
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kerman Medical University
Dyslipidemia
Hs-CRP as Clinical Marker of Inflammatory Atherogenic Dyslipidemia
The objective of this proposal is to study the applicability of the hs-CRP assay in the assessment of CV risk in daily clinical conditions where hyperlipidemic population with or without CHD are currently evaluated.
- Trial name
- NCT00169871
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Cystic Fibrosis
Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis
The purpose of the proposed project is to characterize the neutrophile proteases which participate in the chronic inflammatory phenomenon associated with the cystic fibrosis and which are responsible for the degradation of the…
- Trial name
- Pro-Muco (NCT00750932)
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
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