Clinical trials: Inflammatory Disorder
Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury
Increased Adsorption Membranes During Cardiopulmonary Bypass
Our project intends to reduce cardiac surgery associated - acute kidney injury (CSA-AKI) in non emergent patients with the use of an increased adsorption membrane (oXiris®) connected to the cardiopulmonary bypass (CPB) circuit…
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury, Systemic Inflammatory Response Syndrome, Acute Kidney Injury
- Trial name
- NCT02518087
- Testing
- oXiris®
- Where
- 3 sites in Spain
- Volunteers
- 340 people
- Sponsor
- Hospital Universitari de Bellvitge
IBD - Inflammatory Bowel Disease
Long-term Treatment With Ustekinumab in Patients With Crohn's Disease and Ulcerative Colitis: a Cohort Study
Monocentric observational retrospective/prospective pharmacological study. Clinical records of patients with Ulcerative Colitis and Crohn's Disease who started therapy with Ustekinumab between February 2019 and March 2021 at the…
- Trial name
- NCT06802887
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Ulcerative Colitis
Extension Study of APD334-003 in Patients With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to determine whether etrasimod (APD334) is a safe and effective treatment for ulcerative colitis after 52 weeks of treatment.
- Trial name
- NCT02536404
- Testing
- Etrasimod
- Where
- 127 sites in United States, Australia and 19 more
- Volunteers
- 118 people
- Sponsor
- Arena Pharmaceuticals
Ulcerative Colitis, Inflammatory Bowel Diseases
Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis
FRESCO is a randomized, longitudinal, prospective, three arm, multicentre, double blind study to determine safety and efficacy of repeated faecal microbiota transplantation (FMT) or faecal microbiota filtrate transplantation…
- Trial name
- FRESCO (NCT03843385)
- Testing
- encapsulated faecal microbiota filtrate, encapsulated faecal microbiota
- Where
- 20 sites in Germany
- Volunteers
- 84 people
- Sponsor
- Andreas Stallmach
Severe Asthma, Obesity
Clinical, Inflammatory and Functional Evaluation of a Population of Severe and Obese Asthmatics: Follow up
In the study of a population of severe asthmatics, not controlled despite the treatment conducted, it was possible to evidence 5 phenotypic groups of patients.
- Trial name
- BRASAFUSP (NCT03532685)
- Testing
- Bariatric
- Volunteers
- 110 people
- Sponsor
- University of Sao Paulo General Hospital
Rheumatoid Arthritis, Psoriatic Arthritis
PBR28 PET and Inflammatory Arthritis
The importance of the detection of early inflammatory arthritis is recognised as being essential to the prevention of permanent joint damage.
- Trial name
- NCT02361385
- Testing
- this is not an interventional study
- Where
- 2 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Oxford
Sepsis, Critical Illness
Optimizing Vancomycin Therapy in Children
The purpose of Opt Vanc is to evaluate the feasibility of Bayesian dose adaptation, based on a previously-developed population pharmacokinetic (PK) model and a single optimally timed PK sample, to predict vancomycin area under…
- Conditions
- Sepsis, Critical Illness, Infections, Drug Toxicity
- Trial name
- Opt Vanc (NCT05691309)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Children's Hospital of Philadelphia
Behcet's Syndrome
Rituximab for the Treatment of Severe Ocular Manifestations of Behcet's Disease
The purpose of this study is to find if Rituximab can improve severe ocular lesions of Behcet's Disease.
- Trial name
- NCT00664599
- Testing
- Rituximab, Cytotoxic Combination
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Inflammation, Malnutrition
Effect of Anti-inflammatory Diet on Inflammatory, Oxidative and Nutritional Markers in Hemodialysis Patients
The purpose of this study is to evaluate the effect of especial diet therapy "Anti-inflammatory Diet" on inflammatory, oxidative stress, and nutritional markers in the context of protein-energy wasting syndrome(PEW) in…
- Conditions
- Inflammation, Malnutrition, Protein Energy Wasting Syndrome, Oxidative Stress
- Trial name
- NCT01874106
- Testing
- Diet Therapy, Control Group
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Maryam Ekramzadeh, PhD
Crohn's Disease
Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease
To evaluate the long-term maintenance of response, safety and tolerability of repeated administration of adalimumab in subjects with Crohn's disease who participated in and successfully completed Protocol M02-404 or Protocol…
- Trial name
- NCT00195715
- Testing
- Adalimumab
- Where
- 111 sites in United States, Australia and 13 more
- Volunteers
- 777 people
- Sponsor
- Abbott
Major Depressive Disorder, Rheumatoid Arthritis
Clinical Study of Escitalopram Oxalate Combined With taVNS in Depression and Concomitant Inflammatory Symptoms
This study is expected to include 90 patients with major depressive disorder and rheumatoid arthritis as study subjects.Randomly divided into 3 groups: drug + VNS stimulation group, drug + sham stimulation group and drug group…
- Trial name
- NCT04037111
- Testing
- Transcutaneous electrical vagus nerve stimulation, drug treatment
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Crohn's Disease, Ulcerative Colitis
Predicting Response to Vedolizumab in Pediatric Inflammatory Bowel Diseases
Vedolizumab (VDZ) is a humanized immunoglobulin G1 monoclonal antibody acting against α4β7 integrin which modulates lymphocyte trafficking in the gut.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT02862132
- Testing
- Vedolizumab
- Where
- 15 sites in United States, Denmark and 4 more
- Volunteers
- 142 people
- Sponsor
- Shaare Zedek Medical Center
Metabolic Syndrome
Acute Effects of Dietary Fats and Carbohydrate in Subjects With Metabolic Syndrome
There is increasing evidence suggests that elevated levels of postprandial triacylglycerol (TAG)-rich lipoproteins may promote the development of cardiovascular diseases (CVD).
- Trial name
- NCT01571947
- Testing
- Acute Effects of Fats and Carbohydrate
- Where
- 2 sites in Malaysia
- Volunteers
- 30 people
- Sponsor
- Malaysia Palm Oil Board
Inflammatory Bowel Diseases
Serum NGAL as a Predictor of Clinical and Endoscopic Activity of Inflammatory Bowel Disease
Ulcerative colitis (UC) and Crohns disease (CD) represent the two major forms of inflammatory bowel disease (IBD), characterized by epithelial cell damage and prominent mucosal infiltration by inflammatory cells including…
- Trial name
- NCT05151458
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Crohn Disease
A Dietary Intervention Study on the Microbiome in Crohn's Disease Patients
This protocol is designed to compare the effectiveness of a soy-based diet or identical diet without soy given to patients with Crohn's disease (CD) in remission, patients with active CD, or healthy controls.
- Trial name
- NCT04065048
- Testing
- Soy based diet, Non-soy based diet
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Case Western Reserve University
Ulcerative Colitis
Endomicroscopy in Ulcerative Colitis
This is a confirmatory, multicentric, prospective, randomized, controlled, single-blind study in subjects with long standing ulcerative colitis in clinical remission with indication for surveillance colonoscopy.
- Trial name
- NCT00659867
- Testing
- PENTAX EC-3870CIFK / EC-3870CILK confocal colonoscopes
- Where
- 5 sites in Germany, Italy
- Volunteers
- 182 people
- Sponsor
- PENTAX Europe GmbH
Heart Failure, Myocardial Ischemia
METhotrexate Therapy Effects in the Physical Capacity of Patients With ISchemic Heart Failure (METIS Trial)
The aim of the study is to evaluate the efficacy of methotrexate to improve physical capacity in patients with symptomatic ischemic heart failure.
- Trial name
- METIS (NCT00759811)
- Testing
- Methotrexate
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Ulcerative Colitis (UC)
Immunosuppressant Discontinuation in Elderly Patients With Ulcerative Colitis And Long-term Remission
IDEA is a Phase IV, prospective, randomised, open-label, multicentre clinical trial designed to evaluate the safety and efficacy of withdrawing thiopurines in elderly (≥60 years) patients with ulcerative colitis (UC) who are in…
- Trial name
- IDEA (NCT07248644)
- Testing
- Discontinuation of thiopurines.
- Volunteers
- 304 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Ulcerative Colitis, Autoimmune Diseases
Autologous Ex Vivo Expanded Regulatory T Cells in Ulcerative Colitis
Together with Crohn's disease (CD), ulcerative colitis (UC) is one of the major forms of inflammatory bowel diseases (IBD).Currently, no curative therapy is available, since the pathophysiology of this disease is incompletely…
- Trial name
- NCT04691232
- Testing
- Regulatory T cells
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Arthritis, Rheumatoid
Safety and Efficacy of Mobic® Ampoules in the Initiation of Treatment of Painful Exacerbations of Osteoarthritis, Rheumatoid Arthritis and Other Similar Painful Inflammatory Conditions
Study to determine the safety and efficacy of Mobic® ampoules in the initiation of treatment of painful exacerbations of osteoarthritis, rheumatoid arthritis and other similar painful inflammatory conditions.
- Trial name
- NCT02184052
- Testing
- Meloxicam
- Volunteers
- 121 people
- Sponsor
- Boehringer Ingelheim
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