Clinical trials: Inflammatory Marker
Parkinson Disease
Parkinson's Disease Inflammatory Biomarker Profiling
This study compares a comprehensive panel of immunological biomarkers between Parkinson's disease patients and healthy, environmentally matched participants.
- Trial name
- NCT03633513
- Testing
- LBT-3627, Immunological profiling
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Longevity Biotech
CIDP
Biomark Study: Predict Intravenous Immunoglobulin Responders in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
This study aims analyze the transcriptome to identify predictive biomarkers of IVIG in CIDP patients. 25 patients with a diagnosis of CIDP according to European criteria, naïve of treatment, will be included and followed for 1…
- Trial name
- BIOMARK (NCT02629796)
- Testing
- CIDP treated (IVIG)
- Where
- 18 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Idiopathic Inflammatory Myopathies
Application of Electrical Impedance Myography (EIM) as a Potential Biomarker of Idiopathic Inflammatory Myopathies
1. To assess changes in impedance parameters in Idiopathic Inflammatory Myopathies (IIMs). 2. To assess whether EIM parameters are reflective of disease severity, based on clinical outcome measures of IIMs.
- Trial name
- NCT03918356
- Testing
- electrical impedance myography, healthy control group
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Fabry Disease
Autoimmune and Inflammatory Response Biomarkers in Fabry Disease
The goal of this observational study is to understand the immune response in Fabry disease (FD). We want to find out how the immune response is related to the severity of FD and how it affects patients' quality of life and pain.
- Trial name
- Bio-FAIR (NCT06007768)
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Clinical Infection, Microbial Colonization
Effect of Gut Microbiota and Fecal Inflammatory Marker on Childhood Gastroenteritis
Childhood gastroenteritis establishes gastrointestinal disease and increase the economic burden, and the pediatric population is especially vulnerable to these gastrointestinal infections.
- Conditions
- Clinical Infection, Microbial Colonization, Gastroenteritis, Inflammatory Response
- Trial name
- NCT03856138
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Breast Carcinoma
Effects of White Button Mushroom on Inflammation in Obese Postmenopausal Women at High Risk of Breast Cancer
This clinical trial studies the effects of dietary white button mushroom on inflammation (the body's process of fighting against harmful things) and immune cells (white blood cells) in postmenopausal women with both high body…
- Trial name
- NCT04913064
- Testing
- Questionnaire Administration, White Button Mushroom Extract
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Obesity
Effect of Whole-grape Powder on Body Composition, Fat and Bone Serum Biomarkers in Postmenopausal Women
The purpose of the study is to provide whole-grape powder or a placebo as a supplement to postmenopausal women for 12 weeks to determine the effects on body composition and bone formation.It is hypothesized that 12 weeks of…
- Trial name
- NCT01717820
- Testing
- Freeze-dried whole-grape powder
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Arthritis, Rheumatoid
Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects
This exploratory study aims to assess exposure of healthy subjects to systemic challenge with either LPS or GM-CSF. This will be done by measuring inflammatory mediators and cellular activation markers both in circulation and in…
- Trial name
- NCT03306589
- Testing
- Cantharidin, Lipopolysaccharide, Granulocyte-Macrophage Colony-Stimulating Factor
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Development of Inflammatory Disease Model Protein, Genetic and Microbial Biomarkers
The purpose of this study is to determine if certain levels of proteins lead to inflammation of the gums. One example of such proteins being studied is called Interleukin 1 (IL-1).
- Trial name
- NCT00980525
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sepsis
Novel Biomarkers Related Xuebijing Injection Improves Sepsis
Sepsis is a life-threatening clinical syndrome of organ dysfunction caused by dysregulation of the body's response to infection, and is a common cause of ICU admission for critically ill patients, posing a serious threat to human…
- Trial name
- NCT06920420
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Vaginal Inflammation, Vaginal Infections
Identification of Novel Biomarkers of Cervicovaginal Mucosal Inflammation
This study investigates the response of vaginal and cervical tissue after exposure to three vaginal products: hydroxyethyl cellulose (HEC) placebo, nonoxynol-9 (N9) and imiquimod (IMQ) cream.
- Trial name
- Biomarkers (NCT01593124)
- Testing
- Imiquimod, Nonoxynol-9
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CONRAD
Pulpitis - Irreversible, Pulpitis - Reversible
Observational Cross-sectional Study Aiming to Determine the Correlation Between Pulpal Status and IL-8 and Presepsin Levels in the Pulpal Blood.
Observational cross-sectional study aims to determine the correlation between pulpal status and IL-8 and Presepsin levels in the pulpal blood.
- Trial name
- Cross-section (NCT07466095)
- Testing
- IL-8 and Presepsin levels in the pulpal blood.
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
COVID-19-Associated Encephalitis, Multisystem Inflammatory Syndrome in Children
Investigation of Prognostic Biomarkers, Host Factors and Viral Factors for COVID-19 in Children
Background and objective From this April, there was a COVID-19 outbreak in Taiwan. The first fatal case of pediatric COVID-19 encephalitis was reported on April 19, 2022 and fatal fulminant cerebral edema in other 4 children with…
- Trial name
- NCT05576714
- Testing
- delineate its prognostic biomarker, host genetic factors, immunopathogenesis and viral pathogenesis
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Periapical Periodontitis
Effect of Corticosteroid Injection in Symptomatic Pulpitis Cases
This randomized clinical trial compared standard single-visit root canal treatment with adjunctive submucosal betamethasone and gentamicin in 100 patients with symptomatic irreversible pulpitis, assessing postoperative pain and…
- Trial name
- (SCIP) (NCT07704398)
- Testing
- Corticosteroid, Standard endodontic treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Periodontal Diseases, Smoking
The Effect of Scaling and Root Planing on Oral Inflammatory Biomarkers Among E-cig Users and Non-smokers
Background/Aim: There are no studies that have compared the gingival crevicular fluid (GCF) levels of IL-1β in non-smokers (NS) and electronic nicotine delivery system (ENDS)-users before and after scaling and root planing (SRP)…
- Trial name
- ENDS-SRP (NCT05745324)
- Testing
- Scaling and root planing
- Where
- Kuwait
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Inflammatory Bowel Diseases
Syndecan-1 a Surrogate Marker for IBD
Syndecan-1 is a protein on the surface intestinal cells. previous studies proved low levels of mucosal syndecan-1 levels on the surface of intestinal cells is patients with acute and chronic inflammation due to inflammatory bowel…
- Trial name
- syndecan1 (NCT01430039)
- Testing
- blood sample, Blood sample - venous blood 10 ml.
- Where
- Israel
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Diet Modification, Physical Activity
Denver Garden Environment and Microbiome Study Disease
An interdisciplinary team with extensive garden study experience conducted a pilot randomized controlled clinical trial to see whether gardening reduced risk factors for diseases like cancer and heart disease.
- Conditions
- Diet Modification, Physical Activity, Weight Gain, Chronic Disease
- Trial name
- DGEM (NCT03089151)
- Testing
- Community Garden Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Radiation Cystitis, Urinary Tract Infection (Diagnosis)
Chronic Radiation Cystitis and Effect of Hyperbaric Oxygen Therapy on Patient Reported Outcomes and Urine Inflammatory Biomarkers
Collection of urine, blood, and tissue samples from patients undergoing hyperbaric oxygen therapy
- Trial name
- NCT07368647
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rachel A. Moses
Sepsis
Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational Study
Sepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ dysfunction and increased mortality.
- Trial name
- EMR3-SEPSIS (NCT07896018)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Major Depression Moderate, Major Depression Severe
EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07748091
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa