Clinical trials: Inflammatory Mediators
COPD, COPD (Chronic Obstructive Pulmonary Disease)
Probiotics in COPD: Effects on Symptoms, Lung Function, and Inflammation
The goal of this randomized, placebo controlled, double-blind clinical trial is to find out whether a probiotic supplement can help adults with chronic obstructive pulmonary disease (COPD) breathe better and better control their…
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Probiotic, Probiotic Supplement
- Trial name
- NCT07339280
- Testing
- Probiotic Capsule
- Where
- 5 sites in Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital of Split
Necrotic Teeth With Chronic Apical Periodontitis
Regenerative Endodontics in Mature Necrotic Teeth
The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential \& postoperative pain after using different irrigation…
- Trial name
- NCT07584928
- Testing
- Intervention 1: 1% nanochitosan, Intervention 2: 1% nanochitosan & 17% EDTA
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Symptomatic Apical Periodontitis
Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis
Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis
- Trial name
- (BCvsCaOH) (NCT07585721)
- Testing
- Calcium Hydroxide (Ca(OH)2), Bioceramic Intracanal Medicament
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Atherosclerosis, Inflammation
Sitagliptin Effects on Arterial Vasculature and Inflammation in Obesity
Abdominal obesity is a major risk factor for heart attack, stroke, peripheral vascular disease, dementia, cancer and Type 2 diabetes.
- Trial name
- SAVORO (NCT02576288)
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Periodontal Disease, Coronary Heart Disease
Influence of Periodontal Treatment on Systemic Inflammatory Mediators
Currently the research issue in establishing the role of periodontal disease (PD) in coronary heart disease (CHD) risk is to define the pathways that lead to cause-effect relationship between PD and CHD.
- Trial name
- Perio-CHD (NCT01201746)
- Testing
- Delayed treatment, Periodontal therapy
- Where
- Pakistan
- Volunteers
- 317 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Berberine, COVID-19
The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19
Coronavirus disease 2019 (COVID-19) rapidly spread across China and throughout the world, causing hundreds of thousands died. Studies had shown that "cytokine storms" and subsequent multiple organ dysfunction (MODS) are important…
- Trial name
- BOIFIM (NCT04479202)
- Testing
- Berberine, Montmorrillonite
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Chinese Medical Association
Asthma, Allergic Rhinitis
Montelukast and Nasal Epithelial Cell Inflammatory Responses in Asthma and Rhinitis
The airways of the lung are lined by specialised cells called airway epithelial cells. As well as being at the interface between the lungs and the air we breathe; airway epithelial cell (AEC) function is altered in people with…
- Trial name
- NCT01230437
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Periodontitis
Effect Of Non-Surgical Periodontal Treatment On Lipoxin a4 Levels
The aim of this study was to evaluate the levels of lipoxin A4 (LXA4), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in gingival crevicular fluid (GCF) and saliva in individuals with periodontal healthy and chronic…
- Trial name
- NCT04053660
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ordu University
Acute Respiratory Failure
Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure
This is a randomized, controlled, pilot study of two separate Cohorts of patients from the intensive care unit. Cohort I will enroll 50 patients and randomize to receive one physical therapy session per day or receive usual ICU…
- Trial name
- NCT01707303
- Testing
- Early ICU rehabilitation strategies, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University
Periapical; Infection
Effect of Calcium Silicate Based Root Canal Medicament on Inflammatory Mediators
Calcium hydroxide is generally preferred in endodontics as an intracanal medicament because of its antimicrobial and biological effects. However, the antimicrobial effect of calcium hydroxide is limited.
- Trial name
- NCT06307678
- Testing
- Calcium Hydroxide, Calcium Silicate
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Coronary Artery Disease, Atherosclerosis
Adiponectin and Inflammatory Mediators in Mediastinal Adipose Tissues
Coronary artery disease (CAD), the most common type of heart disease, is caused by hardening of the arteries, or atherosclerosis that is an inflammatory process in which immune mechanisms interact with metabolic risk factors to…
- Trial name
- NCT01176357
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
COPD
Exercise Training and Inflammatory Mediators in COPD
Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020[1].
- Trial name
- NCT03853174
- Testing
- Endurance Training ET, Resistance Training RT
- Where
- Tunisia
- Volunteers
- 28 people
- Sponsor
- Faculty of Medicine, Sousse
Heart Surgery
The Relationship of Adiponectin in Adipose Tissue, Thy-1 in Plaques, and Inflammatory Mediators With Cardiac Diseases
Atherosclerosis is an inflammatory process in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial trees and is known as the main cause of coronary artery…
- Trial name
- NCT02519257
- Testing
- CAD, VHD
- Where
- Taiwan
- Volunteers
- 96 people
- Sponsor
- Far Eastern Memorial Hospital
Cystic Fibrosis
Assessment of Inflammatory Mediators (AIM)
Specific Aim: To determine whether neutrophils, active elastase, and cytokines measured in sputum induced using hypertonic saline are useful screening tests for determining if a particular agent with known anti-inflammatory…
- Trial name
- NCT00219895
- Testing
- Ibuprofen
- Where
- 16 sites in United States
- Volunteers
- 120 people
- Sponsor
- Ramsey, Bonnie, MD
Peri-implantitis
A Comparison of Inflammatory Mediators Surrounding Titanium or Zirconium Implant Abutments
The purpose of this study is to determine whether there are differences in inflammatory markers and bone-mediator protein expression in the fluid surrounding implant abutments manufactured with either titanium or zirconium.
- Trial name
- NCT01870349
- Testing
- Gingival Crevicular Fluid Sampling
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Christopher Barwacz
Diabetic Retinopathy
INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study
The central hypothesis is that inflammation mediators are biomarkers of both systemic diabetes and Diabetic Retinopathy (DR) progression in the aqueous and that sustained topical ketorolac application reduces/suppresses those…
- Trial name
- INSPIRE (NCT04505566)
- Testing
- Ketorolac 0.45% ophthalmic solution, Aqueous PGE2 and inflammatory cytokines measurements
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Stephen J. Kim, MD
Acute Coronary Syndrome, Sleep Disorder
Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome
The purpose of the study is to examine the effects of Eszopiclone, a sleep aid, on inflammatory mediators and coagulability in patients with a recent myocardial infarction.
- Trial name
- NCT00822679
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Arizona
Neonatal Disease
Intestinal Genes Expression Associated With Necrotizing Enterocolitis
In recent days, necrotizing enterocolitis is one of the most common and devastating problem in preterm infants. Therefore, it became a high growing research topic in the last decade.
- Trial name
- NCT04073342
- Testing
- Gene expression of inflammatory mediator (Interleukin 8) and recognition receptor of Toll like receptor (TLR4).
- Volunteers
- 1 people
- Sponsor
- Assiut University
Pancreas Transplantation
GDT Vs ST for Pancreas Transplant Surgery
A Pancreas Transplant is the accepted treatment in patients with Insulin Dependent Diabetes Mellitus (IDDM) and end-organ failure. Simultaneous Pancreas and Kidney (SPK) Transplant is done in over 90% of cases.
- Trial name
- NCT01619904
- Testing
- Goal-Directed Therapy, Standard Therapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Manchester
Knee Injuries
Effects of Intraarticular IL1-Ra on Pain and Inflammatory Mediators After Knee Arhroscopy
This project investigates the relation between acute pain and local inflammation. Pain reported by the patients for knee arthroscopy are compared with local changes in inflammatory mediators by using microdialysis technique.
- Trial name
- NCT01997138
- Testing
- Anakinra 100 mg in 2 ml saline IA
- Where
- Norway
- Sponsor
- Oslo University Hospital