Clinical trials: Inflammatory Mediators
Asthma
Inflammatory Mediators and microRNA Analysis in Premenstrual Asthma
A small number of women with asthma have an increase in asthma symptoms during the premenstrual or menstrual period. This study is being done to investigate the possible causes of this premenstrual increase in asthma symptoms and…
- Trial name
- NCT00837395
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ohio State University
Acute Respiratory Failure
Enteral Feeding Composition and Acute Respiratory Failure
This study aimed to investigate the effect of enteral feeding's macronutrient composition on inflammatory mediators, oxidative stress and outcomes in Intensive Care Unit (ICU) patients with acute respiratory failure.
- Trial name
- NCT02421614
- Testing
- high-protein low-carbohydrate diet with high olive oil, high-protein low-carbohydrate diet with high sunflower oil
- Where
- Iran
- Volunteers
- 48 people
- Sponsor
- Zahra Vahdat Shariatpanahi
Aortic Stenosis
The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
This study is looking at the effects of high spinal anesthesia (also known as total spinal anesthesia) combined with general anesthesia versus general anesthesia alone on the following: Stress response: Patients undergoing aortic…
- Trial name
- NCT00348920
- Testing
- High Spinal and General Anesthesia
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Ulcerative Colitis
Utility of Low Intensity Pulsed Ultrasound Stimulation (LIPUS) to Modulate the Release of Mediators Capable of Reflecting the Inflammatory State in the Affected Colonic Tract of Ulcerative Colitis Patients
The goal of this clinical trial is to learn whether Low Intensity Pulsed Ultrasound (LIPUS) is capable of promoting the release of extracellular vesicles from the gut into the bloodstream of Ulcerative Colitis (UC) patients…
- Trial name
- LIPUSinVIVO (NCT06569888)
- Testing
- LIPUS stimulation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Asthma
Anti-Inflammatory Lipid Mediators in Asthma
The purpose of this study is to demonstrate the efficacy and safety of 10-nitro-9(E)-octadec-9-enoic acid (CXA-10) in obese adult asthmatics.
- Trial name
- ALMA (NCT03680976)
- Testing
- CXA-10
- Where
- United States
- Sponsor
- Sally E. Wenzel MD
Obstructive Sleep Apnea Syndrome
Inflammatory Mediators in Obstructive Sleep Apnoea Syndrome; Mechanisms of Production and the Effect of Long Term Antioxidants Administration
Obstructive Sleep Apnea Syndrome (OSAS) is associated with elevated plasma levels of IL-6 and TNF-α, which cannot be accounted for by obesity (Vgontzas et al Sleep Med Rev 2005;9:211-24, Ciftci et al Cytokine 2004;28:87-91].
- Trial name
- NCT01188005
- Testing
- n-CPAP, Oxygen supplementation, Vitamin A, Vitamin C, Vitamin E, Allopurinol, N-Acetylcysteine
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Athens
Covid19
Determination of the Hemoadsorption Impact as Adjunctive Treatment Upon the Support Therapy of COVID-19
A) Comparing the % of change in each clearances of pro-, and anti-inflammatory mediators (cytokine, chemokines and complement) in the COVID-19 patients treated with CytoSorb as compared to the same patient population who do not…
- Trial name
- NCT04518969
- Testing
- CytoSorb
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Dr David DE BELS
Duchenne Muscular Dystrophy (DMD)
Can External Vagus Nerve Stimulation Reduce Systemic Levels of Inflammatory Mediators in Duchenne Muscular Dystrophy Patients?
The intended investigation is a pilot study to evaluate the safety and efficacy of a novel transcutaneous auricular vagus nerve stimulator system, termed TRAVAGUS ONE, to reduce systemic levels of inflammatory mediators in…
- Trial name
- Travagus One (NCT07543302)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- taVNS AB
Asthma
Asthma/Steroid Withdrawal Study
The investigators propose to study the patterns of metabolite changes in subjects with asthma to determine if there is a predictable pattern prior to, and post, clinical exacerbation. Hypothesis: 1.
- Trial name
- NCT00395239
- Testing
- inhaled corticosteroid
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Myocardial Infarction
The Effects of mETHotrexate Therapy on ST Segment Elevation MYocardial InfarctionS (TETHYS Trial)
Experimental studies suggest that anti-inflammatory and immunomodulatory drugs could reduce the inflammatory profile in acute ischemic disease and reduce the area of ischemia.
- Trial name
- TETHYS (NCT01741558)
- Testing
- Methotrexate, Riboflavin
- Where
- 2 sites in Brazil
- Volunteers
- 80 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Metabolic Syndrome
Beneficial Effects of Exercise and Healthy Diets on Muscle and Adipose Tissue
Both dietary caloric restriction (CR) and physical exercise (PE) exert beneficial effects, which retard or prevent age-related diseases and prolong life span.
- Trial name
- NCT01793896
- Testing
- Control period, Diet Group, Exercise group
- Where
- Chile
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Chile
Chronic Periodontitis
Effect of Nonsurgical Periodontal Therapy Verses Oral Hygiene Instructions on Patients With Chronic Periodontitis
Periodontitis, a bacterial dental biofilm based infectious disease, is a chronic inflammatory disease of the periodontium which results in irreversible destruction of supporting structures of the teeth such as periodontal…
- Trial name
- NCT02208739
- Testing
- Nonsurgical periodontal therapy, Oral hygiene instructions
- Where
- Malaysia
- Volunteers
- 56 people
- Sponsor
- University of Malaya
Molar-Incisor Hypomineralization (MIH)
Assessment of Peridontal Inflamatuar Markers in MIH
The goal of this observational study is to investigate periodontal inflammatory mediators in systemically healthy children aged 8-13 years with and without molar-incisor hypomineralization (MIH) who require initial periodontal…
- Trial name
- NCT07701642
- Testing
- Initial periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cardiac Arrest, Sudden Cardiac Death
Hemodynamic Efficiency of an Hemodialysis Treatment With High Permeability in Post-resuscitation Shock
Rationale: Despite spontaneous cardiac activity recovery, a shock occurs in more than half of patients after resuscitation for cardiac arrest.
- Conditions
- Cardiac Arrest, Sudden Cardiac Death, Shock
- Trial name
- Hyperdia (NCT00780299)
- Testing
- hemodialysis with high permeability (HDHP), CVVH
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Transfusion, Autologous
Effects of Blood Transfusion in Healthy Volunteers
The objective of this study is to assess effects of the storage of PRBC on endothelial function, inflammation and platelet activation in healthy volunteers
- Trial name
- NCT01226498
- Testing
- Red blood Cells auto-transfusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myopia, Astigmatism
Early Changes Among FLEx, LASIK and FS-LASIK
To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (FLEx), laser in situ keratomileusis (LASIK) and femtosecond laser-assisted laser in situ keratomileusis…
- Trial name
- NCT02551796
- Testing
- lenticule extraction, laser in situ keratomileusis, FS assisted laser in situ keratomileusis
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Asthma, Aspirin-Induced
Role of Inflammatory Mediators in AERD
The purpose of this research study is to learn new information about the underlying cause of aspirin-exacerbated respiratory disease (AERD) and the benefit of high-dose aspirin therapy.
- Trial name
- NCT02824523
- Testing
- aspirin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Hepatitis B, Chronic
Observe Change of Endotoxaemia and Related Mediators in Patients With Chronic Hepatitis B Virus (HBV) Infection
This study was designed for changes in endotoxaemia, endotoxin-binding factors, sICAM-1 (soluble intracellular adhesion molecule-1), and cytokines during progression of chronic HBV infection.
- Trial name
- OCEHBV (NCT01107483)
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
One Lung Ventilation in Thoracic Surgery
The Effects of Dexmedetomidine on Inflammatory Mediators After One Lung Ventilation During Video-assisted Thoracoscopic Surgery
During lung surgery, mechanical one-lung ventilation is usually mandatory to provide appropriate surgical condition. However, not only mechanical ventilation is associated with inflammatory response, but also one lung ventilation…
- Trial name
- NCT02439905
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Age-related Cataract
Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL
The purpose of the study it to compare the effects of Holy-Comod and Tears Naturale Forte on ocular surface and tear inflammatory mediators in patients after Phaco+IOL.
- Trial name
- NCT02817191
- Testing
- Hylo-Comod eye drop, Tears Naturale Forte eye drop
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University