Clinical trials: Inflammatory Response
Rheumatoid Arthritis, Systemic Lupus
Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease
The overall objective of this project is to study the influence of modern anti-inflammatory treatments in established inflammatory rheumatic diseases (IRD) on antibody response elicited by pneumococcal vaccination using 13-valent…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus, Sjögren Syndrome, Systemic Vasculitis
- Trial name
- IPS-BOOSTER (NCT03762824)
- Testing
- 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Skane
Giant Cell Arteritis, Polymyalgia Rheumatica
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR).
- Trial name
- GCAIO (NCT06460142)
- Testing
- Aortic/ cardiac magnetic resonance imaging, Vascular ultrasound, Transorbital Ultrasound
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Gastric Residuals Assessment, Prematurity
Does Routine Assessment of Gastric Residuals in Preterm Neonates Influence Time Taken to Reach Full Enteral Feeding?
The study aims to compare routine assessment of gastric residuals versus no assessment of residuals in preterm neonates with respect to time taken for achieving full enteral feeding and the incidence of possible complications…
- Conditions
- Gastric Residuals Assessment, Prematurity, Sepsis Newborn, Necrotizing Enterocolitis of Newborn
- Trial name
- GRASS (NCT03111329)
- Testing
- No aspiration of gastric residuals
- Where
- 2 sites in Czechia, Ireland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic
Neonatal Sepsis, Omphalitis
A Comparative Analysis of 4% Chlorhexidine Versus Methylated Spirit as Prophylaxis of Omphalitis and Sepsis in Newborns
Introduction: Neonatal sepsis in one of the leading cause of death in developing countries. Umbilical cord care is important as it may lead to infection.
- Trial name
- NCT06002295
- Testing
- Chlorhexidine Topical Cream, Methylated Spirit
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Shock, Sepsis
Surrogate of Adequate Perfusion: Bladder Tissue Oxygen Monitoring
The extent and duration of tissue hypoxia is a major determinant of outcome following major, high-risk surgery and in critical illness.
- Conditions
- Shock, Sepsis, Surgery
- Trial name
- SoAP-BOx (NCT03935477)
- Testing
- WellBeing catheter
- Where
- United Kingdom
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Septic Shock
Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock
Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers.
- Trial name
- NCT00378586
- Testing
- Rectal biopsy, Measurement of inflammatory markers in the rectal mucosa, Measurement of rectal lactic acid
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Lipid Disorder, Systemic Inflammatory Response
Evaluation of the Consumption of Lupins in Brine on Metabolic Markers in Healthy Individuals
The aim of the project was the evaluation of the effects of the consumption of different amounts of lupins in brine on lipid, glucose, inflammatory, oxidative stress, gut microbiota profile and (epi)genetic markers in healthy…
- Trial name
- SUPERLUPINO (NCT06595082)
- Testing
- 4-week lupins in brine consumption, 4-week lupins in brine consumption and dietary suggestion
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Teramo
Bloodstream Infections, Short Bowel Syndrome
Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome Infants
The purpose of this research study is to evaluate the effects (good and bad) of supplementation with Glutamine to that of a placebo (L-alanine), on your child and their Short Bowel Syndrome.
- Conditions
- Bloodstream Infections, Short Bowel Syndrome, Development, Nutrition
- Trial name
- NCT01576003
- Testing
- Glutamine, L-alanine
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Lung Function, Heart Rate Variability
Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high…
- Conditions
- Lung Function, Heart Rate Variability, Oxidative Stress, Systemic Inflammatory Response
- Trial name
- NCT01371188
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Overweight, Hypertriglyceridemia
Response to an Intervention With Omega-3 (RIO - Study)
The RIO-Study project is a randomized, controlled, double-blind, crossover trial aimed at determining the effectiveness of omega-3 fatty acids at nutritional doses on lipid metabolism and inflammation in overweight and obese…
- Trial name
- RIO (NCT06538324)
- Testing
- Omega-3, HOSO
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad San Sebastián
Sepsis
HO-1/CREB3 Modulates Golgi Stress in Patients With Sepsis
This study was an ambispective observational cohort study that included sepsis patients hospitalized in the Intensive care unit (ICU) of the Nankai Hospital. All patients met the consensus criteria of sepsis-3.
- Trial name
- NCT06045780
- Testing
- nothing
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tianjin Nankai Hospital
Multiple Trauma
Danger Response in Polytrauma Patients
The NTF_PT_2014 multicenter study aims to collect, store, and analyse plasma and serum from polytrauma-patients (injury severity score ≥25) and corresponding clinical data to address 1) how trauma modulates the release of danger…
- Trial name
- NTF-PT (NCT02682550)
- Testing
- blood drawing
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Inflammatory Response, Abortion, Habitual
Explore the Role of NLRP7 in the Regulation of Progestereone Induced Decidualization of Human Endometrial Stroma Cells
The investigators have found that NLRP7 was upregulated and nuclear translocated in an in vitro model of decidualization. Knock-down or overexpression of NLRP7 reduced or enhanced the expression of decidual marker IGFBP-1.
- Trial name
- NCT04148638
- Where
- Taiwan
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Sepsis
Effects of BCG on Immune Response
In the present study, we want to investigate whether BCG-vaccination enhances the innate immune response in humans in vivo during (single) human endotoxemia.
- Trial name
- NCT02085590
- Testing
- BCG vaccine, Lipopolysaccharide (LPS) E. Coli 1 ng/kg intravenously
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bacteraemia Post Debridement
PVP Iodine Effect on Post Debridement Bacteraemia
The study investigates the effect of supra- and subgingival rinsing of 10% PVP prior to ultrasonic debridement in patients with periodontitis (as compared to rinsing with water) in terms of post treatment bacteraemia.
- Trial name
- PJB 1 (NCT01647347)
- Testing
- Supra- and subgingival rinsing with 10% PVP-iodine, Water
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Chronic Periodontitis
Analysis of Neutrophil Response in Chronic Periodontitis
Recent scientific evidence suggests that the main defence cell of the body (neutrophil) behaves in a different manner in patients with gum disease; namely how they interact with bacteria and their role in defence systems of the…
- Trial name
- NCT01233765
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Birmingham Community Healthcare NHS
Healthy
A Study To Evaluate The Safety And Effects On The Body Of An Investigational Drug Using An Endotoxin-Induced Inflammatory Response Model
An endotoxin challenge will be administered to healthy subjects to induce production of inflammatory markers. An investigational drug or placebo will be administered prior to the endotoxin challenge to assess the effect of the…
- Trial name
- POM (NCT01965600)
- Testing
- PF-06282999, LPS
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Pfizer
Endotoxemia
The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia
The purpose of this study is to determine whether treatment with antibiotics, which harm the gut flora, causes the immune system to be less effective.
- Trial name
- MISSION-2 (NCT02127749)
- Testing
- Endotoxin, Vancomycin, Metronidazole, Ciprofloxacin
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
IBD (Inflammatory Bowel Disease)
E-nose in Evaluating Colitis Activity
The goal of this observational study is to learn whether a rapid stool-based imaging test can help monitor inflammatory bowel disease (IBD) in children.
- Trial name
- SPECTROS (NCT07781215)
- Testing
- Differential Mobile Spectrometry analysis of the stool
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Fetal Growth Restriction, Inflammatory Response
Role of Inflammatory Markers and Doppler Parameters in Late-Onset Fetal Growth Restriction: A Machine Learning Approach
Fetal growth restriction (FGR) is a serious complication in pregnancy that can lead to various adverse outcomes. It's classified into early-onset (before 32 weeks) and late-onset (after 32 weeks), with late-onset associated with…
- Trial name
- NCT06372938
- Testing
- Ultrasound measurement, Laboratory Tests and Inflammatory Markers
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital