Clinical trials: Inflammatory Response
Gram-Positive Bacterial Infections, Nephrotoxicity
Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients
This is a randomized, controlled multicenter clinical trial. The purpose of this study is to compare the continuous infusion of vancomycin with intermittent infusion regarding the effectiveness to reach the target serum level and…
- Conditions
- Gram-Positive Bacterial Infections, Nephrotoxicity, Sepsis
- Trial name
- ETERNITY (NCT03438214)
- Testing
- Vancomycin Continuous infusion, Vancomycin Intermittent infusion
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Volunteer Safety Study
AB103 Peptide Antagonist in Healthy Volunteers
The primary objective of this study is to establish the safety profile and maximum tolerated dose (MTD) of AB103 given as a single intravenous (IV) infusion in healthy volunteers.
- Trial name
- NCT01166984
- Testing
- AB103
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Atox Bio Ltd
Sexual Transmitted Disease, Vaginosis, Bacterial
Impact of Internal Menstrual Protections on Immunity and Vaginal Microbiota
The availability, effectiveness, and safety of menstrual protection represent a key public health issue. However, research on women's menstrual and sexual health remains extremely limited.
- Conditions
- Sexual Transmitted Disease, Vaginosis, Bacterial, Mycosis, Urogenital Disease
- Trial name
- CUPS2 (NCT07199998)
- Testing
- Samples collection (whole blood, urine, vaginal and cervical cells)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre National de la Recherche Scientifique, France
Viremia
Yellow Fever Virus Vaccine and Immune Globulin Study
The purpose of this study is to determine whether immune globulin can limit the amount of yellow fever vaccine virus present in the blood after vaccination without compromising the immunity associated with the yellow fever…
- Trial name
- NCT00254826
- Testing
- YF-VAX® plus saline, 17D YF Vaccine plus Ig,
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Neonatal Sepsis, Sepsis
Probiotics for Prevention Neonatal Infection
Neonatal sepsis (serious infection) continues to be one of the major causes of morbidity and mortality in the newborn period around the world.
- Conditions
- Neonatal Sepsis, Sepsis, Neonatal Infections
- Trial name
- NCT01214473
- Testing
- Synbiotics, Maltodextrin
- Where
- 2 sites in India
- Volunteers
- 4,556 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Heat Stress, Exertional, Inflammatory Response
Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain
The aim of this initial investigational study is to compare the effect of desloratadine on the inflammatory responses to heat stress in firefighters exercising in their personal protective equipment.
- Conditions
- Heat Stress, Exertional, Inflammatory Response, Firefighter Personal Protective Equipment
- Trial name
- NCT05446480
- Testing
- Desloratadine, No Intervention
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Victoria
Hepatitis B, Chronic
Observe Change of Endotoxaemia and Related Mediators in Patients With Chronic Hepatitis B Virus (HBV) Infection
This study was designed for changes in endotoxaemia, endotoxin-binding factors, sICAM-1 (soluble intracellular adhesion molecule-1), and cytokines during progression of chronic HBV infection.
- Trial name
- OCEHBV (NCT01107483)
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Urinary Tract Infections, Sepsis
Use of Antibiotic Based Irrigation for Ureteroscopic Treatment of Urolithiasis
The purpose of the study is to investigate whether the use of gentamicin-based irrigation fluid during ureteroscopy decreases the risk of UTIs and other post-operative infections after surgery.
- Trial name
- NCT06007352
- Testing
- Gentamicin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Chronic Obstructive Pulmonary Disease
Responses Induced by Smoking in Individuals Being Susceptible and Non-Susceptible for Development of COPD
COPD is ranked number 3 by the WHO list of important diseases worldwide and is the only disease with increasing mortality. The pathogenesis of cigarette smoke-induced COPD is obscure, therefore more insight is needed to design…
- Trial name
- NCT00807469
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Top Institute Pharma
T Lymphocyte Disorder
MiRNAs Evaluating Lymphocyte Proliferation and Apoptosis as Well as Prognosis of Sepsis
Sepsis is a systemic inflammatory reaction caused by infection, trauma, etc. In the process of sepsis, the apoptosis of lymphocyte serves as a vital factor of immune dysfunction.
- Trial name
- NCT02756559
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lixin Xie
Lung Function, Heart Rate Variability
Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high…
- Conditions
- Lung Function, Heart Rate Variability, Oxidative Stress, Systemic Inflammatory Response
- Trial name
- NCT01371188
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Acute Inflammatory Response to Non-antigenic Stimulus
Phase 1a Study in Healthy Smokers to Investigate the Effect With MMI-0100 on Airway Inflammation in Induced Sputum After Challenge With Inhaled Lipopolysaccharide
A Phase 1a, randomized, placebo controlled, two-way crossover study is to determine the effect of inhaled MMI-0100 compared to placebo following LPS challenge on inflammatory markers.
- Trial name
- LPS (NCT02515396)
- Testing
- MMI-0100
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Moerae Matrix, Inc.
Sepsis Newborn, Motor Development
Late-onset Sepsis and Development
Neonatal sepsis is classified as early-onset and late-onset sepsis. Early-onset sepsis occurs within the first 72 hours after birth and is associated with a mortality rate of 10-15%.
- Conditions
- Sepsis Newborn, Motor Development, Sensory Integration Dysfunction
- Trial name
- NCT06884969
- Testing
- Test of Sensory Function in Infants, Peabody Motor Development Scale-2
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Pneumonia, Meningitis
Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children
The study aims to evaluate the safety and immunogenicity of the 10-valent and 13-valent pneumococcal conjugate vaccines when administered in an accelerated schedule in Papua New Guinean children, who experience early dense upper…
- Conditions
- Pneumonia, Meningitis, Bacteraemia, Sepsis
- Trial name
- PCV1103 (NCT01619462)
- Testing
- Prevenar 13 and Synflorix
- Where
- Papua New Guinea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Papua New Guinea Institute of Medical Research
Sepsis, Trauma Injury
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems.
- Trial name
- NCT05357170
- Testing
- Human feces collection
- Where
- United States
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Florida
Insulin Sensitivity, Overweight or Obesity
Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human
Objective 1: Characterize indices of systemic inflammation and gut microbiota composition and function after chronic (12 weeks) intake of pulses compared to control diet in human OW/OB-IR participants.
- Conditions
- Insulin Sensitivity, Overweight or Obesity, Inflammatory Response
- Trial name
- PS (NCT04267705)
- Testing
- Control, Black bean, Chickpea
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Lung Injury, Acute, Symptoms and Signs
Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air
Purpose: The primary purpose of this study is to measure pulmonary function, symptoms, and pulmonary inflammatory responses in healthy young adults during and immediately after exposure to a low concentration of ozone (0.070 ppm)…
- Conditions
- Lung Injury, Acute, Symptoms and Signs, Neutrophilia Acute
- Trial name
- LOCONOZ2 (NCT05680831)
- Testing
- 0.070 ppm ozone concentration, Clean air (0.0 ppm ozone)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Martin W. Case
Gingivitis, Depression
Inflammatory Biomarkers in Saliva at Depression
The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis. The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it…
- Conditions
- Gingivitis, Depression, Inflammation, Inflammatory Response
- Trial name
- NCT06427902
- Testing
- Periodontal clinical measurements, Saliva sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Medipol University
COVID-19, Antibody COVID-19
The Role of Obesity in Severe COVID-19 Pathophysiology
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths worldwide.
- Trial name
- SAMO (NCT06968442)
- Testing
- Venipuncture
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Franciscus Gasthuis