Clinical trials: Inflammatory Response
Low Back Pain
Effects of Spinal Manipulative Treatment on Inflammatory Markers in Low Back Pain Patients
It is expected that mechanical low back pain (LBP) is associated with inflammatory changes localized to the affected tissues. Could such changes be detected in cells involved in the inflammatory process in an in vitro model? The…
- Trial name
- NCT01766141
- Testing
- Spinal manipulation
- Where
- Canada
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Canadian Memorial Chiropractic College
Sepsis
Dendritic Cells-Derived Exosomes in Human Sepsis
The amount of peripheral blood exosomes has been confirmed to change in the endotoxin-induced infection. The primary objectives of this study are to compare the changes of peripheral blood dendritic cell-derived exosomes in the…
- Trial name
- NCT02957279
- Testing
- Antibiotics
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Sepsis, Acute Kidney Injury Due to Sepsis
Microbiome and Enteric Signatures in Sepsis-associated Hepatorenal Injury
Sepsis is a major cause of morbidity and mortality in intensive care units. Sepsis-associated liver injury (SALI) and sepsis-associated acute kidney injury (S-AKI) are common complications associated with adverse clinical…
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Gastrointestinal Microbiome, Sepsis-Associated Liver Injury
- Trial name
- MESH (NCT07735182)
- Where
- 6 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Sepsis, Premature Birth
Predictors of Sepsis in Ex-Preterm Infants
The aims of this study are to: Assess whether ex-preterm infants have a persistently immature immune system, which may decrease their ability to respond to infections, when they reach term-corrected gestational age.
- Trial name
- NCT03433846
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Inflammation
Propofol and Perioperative Inflammation
The inflammatory properties of propofol are still under debate. Apolipoprotein A-I (Apo A-I) is involved in the inflammatory process.
- Trial name
- NCT01115179
- Testing
- propofol, Intralipid 10%, Saline
- Where
- Switzerland
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Transfusions
Impact of Feeding on Pro-Inflammatory Cytokine Response in Neonates Receiving a RBC Transfusion
Prior to a non-urgent blood transfusion, subjects will be randomized to either stopping feeds or continuing feeds. The intervention group will be the placement of a subject in the NPO group.
- Trial name
- NCT01949896
- Testing
- NPO, Control group: continue feedings
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Trauma, Critical Illness
Mathematical Modeling of the Acute Inflammatory Response Following Injury
The purpose of this research study is to gather clinical and biologic information from severely injured patients to better understand and characterize the host response to injury and inflammation across several domains.
- Trial name
- NCT00250523
- Where
- United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Septic Shock
Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Respiratory Acidosis
- Trial name
- ENTERPRISE (NCT03966664)
- Testing
- In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins.
- Where
- 2 sites in Czechia, Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sepsis
Glycocalyx and Microcirculation in Sepsis
The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis.
- Trial name
- NCT03960307
- Testing
- Microcirculation and Glycocalyx assessment
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Sepsis
Zambia Chlorhexidine Application Trial
This will be a cluster-randomized controlled trial to assess whether washing the umbilical cord with a disinfectant (4% chlorhexidine) helps to reduce neonatal deaths in Zambia when compared to the current standard of care, dry…
- Trial name
- ZamCAT (NCT01241318)
- Testing
- Chlorhexidine gluconate (4%), Dry cord care
- Where
- Zambia
- Volunteers
- 77,535 people, healthy volunteers welcome
- Sponsor
- Boston University
Inflammatory Response, Sports Performance
Dairy Consumption During a High-intensity, High-volume Training Week in Young Athletes
Our proposed study is a 5-d double-blind randomised cross-over trial, seeking to simulate a training identification camp in competitive adolescent soccer players The purpose of the proposed study is to investigate whether…
- Trial name
- NCT03947801
- Testing
- Greek Yogurt, Isoenergetic carbohydrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brock University
Cryotherapy Effect
Cold Therapy in the Treatment of Exercise-induced Muscle Damage
Subjects were randomly placed in five groups: (1) single exposure at 5°C in cold water immersion, (2) single exposure at 15°C in cold water immersion, (3) multiple exposures at 10°C in cold water immersion, (4) whole body…
- Trial name
- NCT02341612
- Testing
- single exposure at 5°C in CWI, single exposure at 15°C in CWI, multiple exposures at 10°C in CWI
- Where
- Brazil
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Chronic Periodontitis
Analysis of Neutrophil Response in Chronic Periodontitis
Recent scientific evidence suggests that the main defence cell of the body (neutrophil) behaves in a different manner in patients with gum disease; namely how they interact with bacteria and their role in defence systems of the…
- Trial name
- NCT01233765
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Birmingham Community Healthcare NHS
Sepsis
The Effect and Mechanism of lncRNA NBR2 Regulating Endothelial Pyroptosis by Targeting GSDMD in Sepsis
Sepsis is a life-threatening disease characterized by multi-organ failure due to dysregulated host response to infection, with high global mortality of 30-50%.
- Trial name
- NCT04427371
- Testing
- the levels of pyroptosis
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jianfeng Xie
Breast Cancer, Circadian Rhythms
The Effects of Light Therapy to Treat Cancer-related Side Effects
Severe fatigue, depression, sleep problems and cognitive impairment are the most commonly reported side effects of cancer treatment.
- Conditions
- Breast Cancer, Circadian Rhythms, Fatigue, Sleep Disturbance
- Trial name
- NCT04418856
- Testing
- Light Glasses (Experimental), Light Glasses (Comparison)
- Where
- Iceland
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Reykjavik University
Meningitis, Septicemia
Understanding the Immune Response to Meningitis Vaccines
The purpose of the study is to evaluate and compare the immune response to two vaccines against 4 related bacteria: meningococcal serogroups A, C, W-135 and Y.
- Trial name
- NCT00901940
- Testing
- Meningococcal (Groups A, C, Y and W-135) Conjugate, Meningococcal polysaccharide A, C, Y and W135 and Menveo
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Neonatal SEPSIS
Neonatal Sepsis at Neonatal Intensive Care Units in Ghana
Background: Neonatal sepsis is a major contributor to global under five mortality. In developing countries a major proportion of neonatal sepsis is thought to emanate from the healthcare setting, due to challenges in infection…
- Trial name
- NCT03755635
- Testing
- The WHO multimodal hand hygiene strategy
- Where
- Ghana
- Volunteers
- 5,433 people, healthy volunteers welcome
- Sponsor
- Stephanie Bjerrum
Overweight, Obesity
Pain and Acetaminophen in Women Study
The purpose of this study is to evaluate the influence of acetaminophen on pain response and inflammation.
- Conditions
- Overweight, Obesity, Healthy Adults
- Trial name
- PAWS (NCT04573426)
- Testing
- Acetaminophen, Weight stigma vignette, Control vignette
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Endotoxemia
Blockade of Vascular Potassium Channels During Human Endotoxemia
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine.
- Trial name
- NCT00185003
- Testing
- endotoxin, Potassium channel blockers: TEA, Quinin, Tolbutamide, L-NMMA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center