Clinical trials: Inflammatory Response
Preterm Infants, Term Infants
The Intestinal Innate Immune System in Newborns. Development and Inflammation in Health and Disease
The goal of this observational study is to determine the normal development of the human intestinal immune system in premature and mature neonatal life and to determine the pathophysiology behind life-threatening gastrointestinal…
- Conditions
- Preterm Infants, Term Infants, Necrotising Enterocolitis, Atresia; Bowel
- Trial name
- INTINE (NCT06092463)
- Where
- 2 sites in Denmark
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spinal Cord Injury
Vagal Nerve Stimulation to Reduce Inflammation and Hyperadrenergia
The purpose of this research device study is to learn more about the autonomic nervous system. This system uses nerves to send information from the brain to the rest of the body by electrical signaling and has two divisions, the…
- Trial name
- NCT02983266
- Testing
- InTENsity MicroCombo
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Wounds and Injuries
Effect of Leukoreduced Blood Transfusions on Infection Following Trauma
The purpose of this study is to determine if leukoreduced blood transfusions reduce the risk of infection following trauma. Specifically, the investigators intend to evaluate whether there are clinically relevant differences in…
- Trial name
- NCT00135291
- Testing
- Leukoreduced blood transfusion
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Obesity, Hyperglycemia
The Effect of a Bifidobacterium and Polydextrose on Body Fat Mass
Obesity is a major problem worldwide, and it is related to abnormalities in glucose and lipid metabolism. The purpose of this study is to investigate the effect of a dietary supplement containing probiotic (Bifidobacterium…
- Conditions
- Obesity, Hyperglycemia, Insulin Resistance
- Trial name
- MetSProb (NCT01978691)
- Testing
- Bifidobacterium animalis ssp. lactis 420, Polydextrose
- Where
- 4 sites in Finland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Danisco
Healthy, Helminthiasis
Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections
This study will compare the structure, chemical composition and other characteristics of skin and blood in people with and without parasitic infections. Cell samples will be taken from blisters produced by suction blistering.
- Trial name
- NCT00004996
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Athlete
Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes
The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer…
- Trial name
- NCT03321110
- Testing
- Coenzyme Q10
- Where
- Taiwan
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Neonatal Sepsis
Clinical Impact of an Antibiotic Stewardship Program in a Neonatal Intensive Care Unit
Antimicrobial resistance is one of the biggest and most urgent threat to global health. Initiating antimicrobial stewardship programs is one of the main efforts to control antimicrobial resistance.
- Trial name
- NCT04039152
- Testing
- locally adapted neonatal sepsis treatment protocol
- Where
- Egypt
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Breast Cancer
Effects of SPSIP Block on Perioperative Inflammation and TLR4 in Breast Cancer Surgery
This study will investigate whether the serratus posterior superior intercostal plane (SPSIP) block improves postoperative recovery after breast cancer surgery. Participants will be randomly assigned to one of two groups.
- Conditions
- Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Breast Cancer, Toll-Like Receptors
- Trial name
- SPSIP-TLR4 (NCT07843212)
- Testing
- Serratus posterior superior intercostal plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mucahide Emine Fidancı Kuas
Sepsis
PD-1/PD-L1 Pathway Study on Septic Patients
The investigators want to identify that whether PD-1/PD-L1 pathway will change in human sepsis, and whether PD-1/PD-L1 pathway play an important role in sepsis induced immunosuppression.
- Trial name
- NCT01161745
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Malaria, Pregnancy Malaria
Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania
Sulfadoxine-pyrimethamine (SP) is currently recommended by the World Health Organization for use as intermittent preventive treatment against malaria in pregnancy (IPTp) in areas of moderate to high malaria transmission.
- Conditions
- Malaria, Pregnancy Malaria, Cardiotoxicity, Cardiac Safety
- Trial name
- NCT02909712
- Testing
- sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DHA-PQP)
- Where
- Tanzania
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Mortality
Lufwanyama Neonatal Survival Project
We seek to determine whether we can reduce day 28 mortality in Zambian newborns by training traditional birth attendants a modified version of the neonatal resuscitation protocol (NRP) and by improving their abiltiy to identify…
- Trial name
- LUNESP (NCT00518856)
- Testing
- Neonatal resuscitation protocol, Standard of care
- Volunteers
- 3,559 people, healthy volunteers welcome
- Sponsor
- Boston University
Inflammatory Response
Persistent Readiness Through Early Prediction Immunization Study
This study will enroll volunteers in an open-format (outside hospital) setting, to complete novel data collection/analysis of biomarkers, facial images, and audio-recording to establish an optimal set of parameters to predict…
- Trial name
- PREP DOD (NCT05346302)
- Testing
- Pneumovax 23, Typhim VI, Saline
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Inflammation, Skin Abnormalities
Effects of Bend Beauty's Anti-Aging Formula on Inflammatory Markers
This is a phase IV, randomized, double-blind, placebo-controlled, three-arm, parallel intervention study including three groups of 25 subjects between 35-65 years of age, treated with either Bend Beauty's Anti-Aging Formula, fish…
- Conditions
- Inflammation, Skin Abnormalities, Skin Pigment, Inflammatory Response
- Trial name
- BENCHMARK (NCT03862872)
- Testing
- Anti-Aging Formula, Control Fish Oil
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bend Beauty Inc.
Volume Overload, Tissue Perfusion
Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness
43 patients between 18-60 years presenting with criteria of sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection, suspected or documented infection and an acute increase ≥2 SOFA…
- Trial name
- NCT05104528
- Testing
- OSYPKA Medical ICONTM Noninvasive CardiometerTM Model C3, Fujifilm Sonosite M-Turbo C Ultrasound system
- Where
- Egypt
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Phototherapy
Effects of Light Emitting Diodes (LED) Therapy in Rugby Athletes
Therapy with light emitting diodes (LED) is a good resource to accelerate the recovery of the athlete and reduce muscle damage caused by exercise.
- Trial name
- NCT03728439
- Testing
- LED before, LED interval, LED after
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Severe Sepsis
Pharmacokinetics, Safety, Tolerability and Pharmacodynamics of BMS-986189 in Healthy Subjects
The main purpose of this study is to measure the amount of study drug (BMS-986189) in the blood and urine and to see if BMS-986189 is safe and well-tolerated in healthy people after a single dose.
- Trial name
- NCT02739373
- Testing
- BMS-986189
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Sepsis, Acute Infection
A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.
The study is a multi-center, prospective, observational clinical study enrolling patients from at least 3 medical centers. Study population will include patients over the age of 18 years.
- Trial name
- NCT06665542
- Where
- 8 sites in United States, Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Sepsis, Septic Shock
Release of Nociceptin From Granulocytes in Sepsis
Nociceptin is a protein found in the body, with a number of functions in the central nervous system, blood vessels and the gut. There is evidence that it may have a role in controlling the immune response to infection, and may…
- Conditions
- Sepsis, Septic Shock, Sepsis Syndrome, Severe Sepsis
- Trial name
- NCT03037281
- Testing
- Septic
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Sepsis, Acute Lung Injury
Biological Markers to Identify Early Sepsis and Acute Lung Injury
There are no clear markers to identify sepsis and acute lung injury at early stage in clinical settings which would result in improved survival of the patients. In collaboration with the research team led by Dr. Zhang at St.
- Trial name
- NCT00825357
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chimei Medical Center
Crohn's Disease, Ulcerative Colitis
Proteomic Analysis of Crohn's Disease Macrophages in Response or Not to AIEC
The M2iSH laboratory showed with two previous clinical trials that Crohn's Disease (CD) macrophages present i) a defect to control Adherent-Invasive Escherichia coli (AIEC) infection related to polymorphisms associated with CD…
- Trial name
- ROMAN (NCT03404557)
- Testing
- Proteomic analysis
- Where
- France
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand