Clinical trials: Influenza Like Illness
Influenza -Like Illness, Influenza (Healthy Volunteers)
Mucosal and Systemic Immunity Correlates of Protection Against Influenza in Young Children, Aged 2-5 Years (MUSIC-Flu)
Title: Mucosal and systemic immunity correlates of protection against influenza in young children (MUSIC-Flu). The goal of this observational study is to better understand how immune responses in the blood and mucosa are linked…
- Trial name
- MUSIC-Flu (NCT07861854)
- Where
- South Africa
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute for Communicable Diseases, South Africa
Influenza, Influenza-like Illness
Abbott ID NOW Point-of-Care Testing
With the rapid aging of the global population, long-term care facilities (LTCFs) have become an increasingly important component of modern public health systems.
- Trial name
- IDNOW2026 (NCT07846423)
- Testing
- Abbott ID NOW Point-of-Care Testing, Standard Laboratory-Based RT-PCR Diagnostic Pathway
- Where
- Taiwan
- Volunteers
- 1,080 people
- Sponsor
- China Medical University Hospital
Malaria, Dengue
Validation of a CDSA Strategy to Reduce Antibiotic Prescription in Senegal
This trial aims to validate a novel clinical care strategy based on a electronic clinical decision support algorithm (CDSA) combined with point of care rapid diagnostic tests by evaluating its impact on antibiotic prescription…
- Conditions
- Malaria, Dengue, Influenza -Like Illness, Diarrhea
- Trial name
- NCT05050825
- Testing
- Patient clinical management based on the CDSA strategy
- Where
- 4 sites in Senegal
- Volunteers
- 470 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Respiratory Tract Infections (RTI), Influenza -Like Illness
Virological Surveillance of Acute Respiratory Infection in Primary Health Care in Metropolitan France
Every year in the fall and winter, numerous respiratory viruses (such as influenza viruses, SARS-CoV-2 (COVID-19), RSV, rhinovirus, and metapneumovirus) circulate in mainland France, causing acute respiratory infections (ARIs).
- Conditions
- Respiratory Tract Infections (RTI), Influenza -Like Illness, Influenza, COVID - 19
- Trial name
- RS-viro IRA (NCT07599449)
- Testing
- saliva sampling, Nasopharyngeal swab
- Where
- France
- Volunteers
- 25,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Acute Respiratory Infection, Influenza-like Illness
Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care
The ImpProGUIDE study aims to find out whether implementing new Swiss national guidelines for acute respiratory infections (ARI) can help to reduce antibiotic prescribing in primary care.
- Trial name
- ImpProGUIDE (NCT07396428)
- Testing
- Training Session on acute respiratory infection guideline within a multifaceted implementation strategy
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Acute Respiratory Infection, Influenza-like Illness
ORCHARDS-AIR Study
The purpose of this observational study is to compare the effectiveness of air surveillance and to better understand the relationship between household transmission and viruses detected in the air.
- Trial name
- NCT07298967
- Testing
- Nasal swab, Indoor air quality monitor
- Where
- United States
- Volunteers
- 422 people
- Sponsor
- University of Wisconsin, Madison
Influenza, Influenza-like Illness
A Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD
A total of 18,000 eligible subjects (or 6,000 subject distributed evenly between the 3 study arms) will be enrolled. Eligible subjects will be randomized in 1:1:1 (cell-culture-based vaccine, the recombinant vaccine, or the…
- Conditions
- Influenza, Influenza-like Illness, Influenza Vaccines
- Trial name
- PAIVED (NCT03734237)
- Testing
- Egg based influenza vaccines, Recombinant influenza vaccines, Cell-culture based influenza vaccines
- Where
- 9 sites in United States
- Volunteers
- 15,448 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Respiratory Tract Infections (RTI), Influenza-like Illness
Clinical Assessment of Respiratory Events for Kids: Integrating Diagnostics and Stewardship
This study, called Care4Kids, aims to improve the management of respiratory infections in children visiting emergency departments.
- Conditions
- Respiratory Tract Infections (RTI), Influenza-like Illness, Children
- Trial name
- CARE4KIDS (NCT07453914)
- Testing
- SPOTFIRE R
- Where
- 3 sites in France, Greece and 1 more
- Volunteers
- 720 people
- Sponsor
- BioMérieux
COVID-19 Respiratory Infection, Respiratory Virus Infection
Preventing Respiratory Viral Illness Invisibly
Elderly people who have multiple health problems are at higher risk of illness from viral respiratory infections, such as influenza (the flu) and COVID-19.
- Conditions
- COVID-19 Respiratory Infection, Respiratory Virus Infection, Influenza -Like Illness
- Trial name
- PRiVII (NCT05084898)
- Testing
- Far-UVC light as an additional method of disinfection
- Where
- 3 sites in Canada
- Volunteers
- 550 people
- Sponsor
- Kenneth Rockwood
Acute Respiratory Infections, Febrile Illnesses
The Fever Clinic Acute Respiratory Cohort
This prospective cohort study aims to characterize the natural progression and outcomes of acute respiratory infections among patients presenting to fever clinics.
- Conditions
- Acute Respiratory Infections, Febrile Illnesses, Community-acquired Pneumonia, Viral Respiratory Tract Infections
- Trial name
- FACTS (NCT07278700)
- Testing
- No intervention involved
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Fudan University
Patient With Influenza Like Illness
Effect of Influenza Vaccination of Healthcare Workers (HCW) on the Risk of Influenza in Patients Hospitalized in Short Stays Units
Hospital acquired influenza is associated with significant morbidity and mortality in hospitalized patients notably elderly patients. Vaccination of HCW is recommended to prevent influenza transmission in healthcare setting.
- Trial name
- NCT02198638
- Testing
- A nasal swab
- Where
- 2 sites in France
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Influenza, Acute Respiratory Infection
FluSAFE: Flu SMS Alerts to Freeze Exposure
Influenza infection results in an estimated 31 million outpatient visits, 55,000 to 974,200 hospitalizations, and 3,000 to 49,000 deaths.
- Conditions
- Influenza, Acute Respiratory Infection, Influenza-like Illness
- Trial name
- NCT03274310
- Testing
- Educational text messages
- Where
- United States
- Volunteers
- 1,918 people, healthy volunteers welcome
- Sponsor
- Columbia University
Influenza, Influenza Like Illness
Seasonal Influenza Vaccine Effectiveness Study in Kenya
Influenza is an important cause of acute respiratory infections (ARI) worldwide. Seasonal influenza causes an estimated 250,000-500,000 deaths and 3-5 million severe illnesses each year (WHO, 2009), and pandemic 2009 H1N1…
- Conditions
- Influenza, Influenza Like Illness, Severe Acute Respiratory Illness
- Trial name
- NCT01432340
- Testing
- Seasonal influenza vaccine
- Where
- 2 sites in Kenya
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Gideon Emukule
Headache Disorders, Influenza -Like Illness
InfluenCEF Study: Study on the Headache Associated With Influenza Infection
The goal of this observational analytic study with a cohort desing is to evaluate the epidemiology, risk factors and clinical phenotype of headache during Influenza infection.
- Conditions
- Headache Disorders, Influenza -Like Illness, Head Pain, Migraine
- Trial name
- INFLUENCEF (NCT05704335)
- Testing
- Questionnaire administration
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Influenza -Like Illness
Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness
a multicenter, double-blind, randomized, placebo-controlled trial. Patients aged less than 60 years old with no previous medical history consulting the emergency department for covid and covid-like illness and who were not…
- Trial name
- kela-cov (NCT05670444)
- Testing
- kelavit
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Hôpital Universitaire Sahloul
Influenza, Influenza-like Illness
Adjuvanted Influenza Vaccination Year 2 Follow-On Survey
The purpose of this study is to determine if different influenza vaccines produce different outcomes in nursing facility residents receiving the required annual influenza vaccination.
- Conditions
- Influenza, Influenza-like Illness, Influenza, Human
- Trial name
- NCT03599739
- Testing
- Influenza
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- Insight Therapeutics, LLC
Influenza, Influenza-like Illness
Adjuvanted Influenza Vaccination in U.S. Nursing Homes
This study is powered to prospectively evaluate the relative effectiveness of adjuvanted trivalent influenza vaccine (aTIV; FLUAD) in preventing influenza mortality, hospitalization, and functional decline in a nursing home…
- Trial name
- NCT02882100
- Testing
- adjuvanted trivalent influenza vaccine, trivalent influenza vaccine
- Where
- United States
- Volunteers
- 823 people
- Sponsor
- Insight Therapeutics, LLC
Influenza, Influenza -Like Illness
Recombinant Influenza Vaccination in U.S. Nursing Homes
Based on recent evidence on the mutation of the A/H3N2 strain in egg-grown vaccine, the investigators will study the quadrivalent recombinant influenza vaccine (RIV4, Flublok) compared to the standard dose quadrivalent vaccine…
- Conditions
- Influenza, Influenza -Like Illness, Influenza, Human
- Trial name
- NCT03965195
- Testing
- Recombinant Influenza Vaccine, Standard Dose Quadrivalent Influenza Vaccine
- Where
- United States
- Volunteers
- 1,989 people, healthy volunteers welcome
- Sponsor
- Insight Therapeutics, LLC
Influenza, Influenza, Human
Baloxavir Versus Oseltamivir for Nursing Home Influenza Outbreaks
Influenza outbreaks are a prevalent event in nursing homes (NHs). We will study baloxavir compared to oseltamivir when used for influenza prophylaxis when facilities identify an index incident case of influenza.
- Conditions
- Influenza, Influenza, Human, Influenza -Like Illness
- Trial name
- NCT05012189
- Testing
- Oseltamivir, Baloxavir
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Insight Therapeutics, LLC
Influenza, Influenza-like Illness
Evaluation of Psychometric Testing Properties of Severity Symptom Grading Scale of Influenza Infection: Flu-PRO Stage III
There is no standardized method for evaluating the symptoms of influenza. A standardized instrument for measuring influenza symptoms, with appropriate scientifically derived content and construct validity would have value for…
- Trial name
- FluPRO3 (NCT02302924)
- Where
- 5 sites in United States
- Volunteers
- 535 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine