Clinical trials: Infusion Rates
Spinal Aneshtesia, Hypotension After Spinal Anesthesia
Comparing Two Different Norepinephrine Infusion Rates for Prophylaxis Against Spinal-induced Hypotension in Elderly
The current study aims to determine whether norepinephrine infusion rate (0.07 mcg/kg/min) is non-inferior to the higher dose (0.1 mcg/kg/min) in maintaining intraoperative blood pressure maintaining blood pressure of elderly…
- Conditions
- Spinal Aneshtesia, Hypotension After Spinal Anesthesia, Elderly (People Aged 65 or More)
- Trial name
- NCT07077265
- Testing
- Norepinephrine (0.1 μg/kg/min), Norepinephrine (0.07 μg/kg/min)
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Kasr El Aini Hospital
Healthy
A Study to Evaluate Lu AF90103 in Healthy Men
The purpose of this study is to investigate the safety and tolerability of Lu AF90103 and what the body does to Lu AF90103 after single doses of the drug administered directly into a vein.
- Trial name
- NCT04940949
- Testing
- Lu AF90103
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Peripheral Vascular Disease
Study of Safety and Tolerability of UNIFUZOL (Solution for Infusions) in Healthy Volunteers
Unifusol (R) is a solution of arginine sodium succinate for intravenous infusions. Its effects include vasodilation, protection of inner layer of blood vessels and improvement of blood viscosity.
- Trial name
- NCT03028285
- Testing
- arginine sodium succinate
- Where
- 2 sites in Russia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Type 1 Diabetes
Flat and Circadian Insulin Infusion Rates in Continuous Subcutaneous Insulin Infusion
Randomised controlled trial to contribute to the evidence base for the optimal initial insulin profile for adults with type 1 diabetes commencing insulin pump therapy.
- Trial name
- FIRST1D (NCT04267770)
- Testing
- Insulin (circadian), Insulin (flat rate)
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Imperial College London
Primary Immunodeficiency Disease
High Infusion Rate Study of Immunoglobulin Intravenous (Human) 10% (NewGam)
This was a prospective, open-label, non-controlled, non-randomized multicenter Phase III study of 2 multiple-dose intravenous NewGam regimens (every 3 weeks or every 4 weeks, continuing the patient's infusion interval in the main…
- Trial name
- NGAM-05 (NCT01313507)
- Testing
- NewGam
- Where
- 6 sites in United States
- Volunteers
- 21 people
- Sponsor
- Octapharma
Coronary Artery Bypass, Cardiopulmonary Bypass
The Effect of Nitroglycerin Infusion Rate on Cerebral Rewarming During Hypothermic Coronary Artery Bypass Grafting
Glyceryl trinitrate is used in coronary artery bypass grafting surgery. This surgery frequently employs hypothermic cardiopulmonary bypass, where the whole body is cooled down to 28-32 °C to arrest the heart, and protect the…
- Trial name
- nitrotherm (NCT03251599)
- Testing
- Glyceryl trinitrate 0.2, Glyceryl trinitrate 0.5
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Recep Tayyip Erdogan University
Healthy
A Study of ARC-520 at Varying Infusion Rates in Healthy Adult Volunteers
Single doses of ARC-520 will be evaluated at varying infusion rates and by slow bolus push.
- Trial name
- NCT02535416
- Testing
- ARC-520, cetirizine, diphenhydramine
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals
Colorectal Cancer, Liver Metastases
Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver
Background: Many people with colorectal cancer get liver metastases. Standard treatment for this is a combination of chemotherapy drugs. Directing the chemotherapy to the liver may be effective.
- Conditions
- Colorectal Cancer, Liver Metastases, Colorectal Adenocarcinoma, Colorectal Cancer With Hepatic Metastases
- Trial name
- NCT03366155
- Testing
- Codman 3000 constant flow pump catheter, Panitumumab, FUDR-Dex
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Purpura, Thrombocytopenic, Idiopathic
Rapid Infusion Of Immune Globulin Intravenous (IGIV) In Patients With ITP
The objective of this study is to determine if the safety and tolerability of Immune Globulin Intravenous (Human), 10% Caprylate/Chromatograph Purified (IGIV-C) is similar when infused at two different infusion rates.
- Trial name
- NCT00220727
- Testing
- Immune Globulin IV [Human], 10% Caprylate/Chromatography Purified
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Grifols Therapeutics LLC
Congenital Hyperinsulinism
CSI-Glucagon for Prevention of Hypoglycemia in Children With Congenital Hyperinsulinism
This is a Phase 2, multi-center, randomized, placebo-controlled, double-blind trial with open-label follow-up designed to assess the efficacy of Xeris Glucagon delivered as a continuous subcutaneous infusion to prevent…
- Trial name
- NCT02937558
- Testing
- Glucagon
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Xeris Pharmaceuticals
Determine If Adherence Rates with IV Antibiotics in OPAT Have a Correlation to Hospital Readmission Rates
IV Ensure in Patients Receiving OPAT
The purpose of remote therapeutic monitoring is to provide oversight and evaluation of patients receiving IV medications in the home setting post-acute.
- Trial name
- NCT06623318
- Testing
- Remote therapeutic monitoring device
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- IV Ensure
Contrast Enhanced Computed Tomography (CT) Scanning
Effect of Three Side Hole Infusion Catheter on CT Image Quality Compared to a Standard Infusion Catheter
The purpose of this research study is to compare two types of catheters used for infusing the contrast dye necessary for viewing internal organs during computed tomography (CT) scanning.
- Trial name
- NCT02943226
- Testing
- Becton Dickinson Nexiva Diffusics System, Standard intravenous catheter
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Panzyga in CIDP Administered at Different Infusion Rates
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a treatable form of peripheral neuropathy with suspected autoimmune cause.
- Trial name
- Panzyga-CIDP (NCT03166527)
- Testing
- Immune Globulin 10% Intravenous Solution
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Vera Bril
Healthy
A Study to Evaluate the Use of a Graded Infusion of Intravenous Glucose in the Assessment of Insulin Secretion Rates (MK-0000-078)
A two period pilot study to determine if a graded glucose infusion using a glucose (20% dextrose [D20]) intravenous infusion can be properly implemented and will be well tolerated in healthy subjects.
- Trial name
- NCT01021462
- Testing
- Comparator: graded infusion of intravenous glucose
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis
A Study Comparing Infusion Rates of Tocilizumab in Patients With Moderate to Severe Rheumatoid Arthritis
This 2 arm study will compare the incidence of tocilizumab-related infusion reactions, using 2 different infusion times, in patients with moderate to severe rheumatoid arthritis who have shown an inadequate response to DMARDs…
- Trial name
- NCT00887341
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 24 sites in Spain
- Volunteers
- 76 people
- Sponsor
- Hoffmann-La Roche
Intraosseous Access, Infusion Rates
Infusion Flow Rates and Blood Sampling
To evaluate infusion flow rates attainable when using the proximal humerus and proximal tibia IO vascular access sites. To evaluate the intraosseous infusion physiology when using the proximal humerus and proximal tibia IO…
- Conditions
- Intraosseous Access, Infusion Rates, Intraosseous Blood, Venous Blood
- Trial name
- NCT02021617
- Testing
- Intraosseous access
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vidacare Corporation
Hemophilia A or B With Inhibitors
FEIBA Reconstitution Volume Reduction and Faster Infusion Study (FEIBA STAR)
The purpose of this study is to: 1. To evaluate the tolerability and safety of infusing reduced volume Factor Eight Inhibitor Bypassing Activity (FEIBA) at the standard infusion rate of 2 U/kg/min 2.
- Trial name
- NCT02764489
- Testing
- FEIBA
- Where
- 3 sites in Croatia, North Macedonia and 1 more
- Volunteers
- 45 people
- Sponsor
- Baxalta now part of Shire
Healthy
A Study to Assess the Effects of Exenatide on Insulin Secretion Rates Using a Graded Infusion of Intravenous Glucose (0000-099)(COMPLETED)
A four-period study to evaluate if the grade glucose infusion procedure will be able to detect an increase in beta-cell glucose sensitivity from exenatide compared to no treatment in healthy subjects.
- Trial name
- NCT01021527
- Testing
- Comparator: Treatment A, Comparator: Treatment B, Comparator: Treatment C
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC