Clinical trials: Inhalation; Gas
Hypoxemia, Pneumonia, Viral
Nitric Oxide Therapy for COVID-19 Patients With Oxygen Requirement
Preliminary data support the effect of Nitric Oxide (NO) on improving the oxygenation in mechanically ventilated patients and spontaneously breathing patients with COVID-19.
- Conditions
- Hypoxemia, Pneumonia, Viral, Coronavirus Infection
- Trial name
- NICOR (NCT04476992)
- Testing
- Nitric Oxide-Sessions, Nitric Oxide-Continuous and Sessions
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Neurocognitive Disorders, Inhalation; Vapor
Effect of Low Flow Anesthetics on Neurocognitive Decline in the Elderly
This study aims to investigate the effect of inhaled anesthetics with a low fresh gas flow on cognitive function of elderly patients undergoing elective surgery
- Trial name
- NCT05548998
- Testing
- General anesthesia with low fresh gas flow, General anesthesia with high fresh gas flow, Mini mental state examination
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Acute Respiratory Distress Syndrome
Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)
Numerous trials support the efficacy and safety of volatile anesthetic agents, namely inhalation of sevoflurane through dedicated devices, for the sedation of ICU patients.
- Trial name
- SEGA (NCT02166853)
- Testing
- sevoflurane, midazolam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Distress Syndrome, Adult
Combined High Frequency Oscillation and Tracheal Gas Insufflation for Severe Acute Respiratory Distress Syndrome
In the past five years, there is a growing body of published evidence on the feasibility, and oxygenation and lung protection benefits of high frequency oscillation (HFO) in the acute respiratory distress syndrome (ARDS).
- Trial name
- NCT00416260
- Testing
- High Frequency Oscillation and Tracheal Gas Insufflation
- Where
- Greece
- Volunteers
- 54 people
- Sponsor
- University of Athens
Waste Anesthetic Gas (WAG) Emanating From Patients Post-operative Recovery
Evaluation and Control of WAG in PACU Within Patient and Caregiver Breathing Zone
The purpose of this study is to evaluate anesthetic gas in the PACU within patient and caregiver breathing zones.
- Trial name
- NCT02428413
- Testing
- ISO-Gard Mask, Standard oxygen mask
- Volunteers
- 125 people
- Sponsor
- Teleflex
Hypoxia, Normobaric Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Normobaric Hypoxia, Altitude Hypoxia, Right Heart Function
- Trial name
- RIVER-H (NCT07431567)
- Testing
- Normobaric Hypoxia
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mona Lichtblau
Foreign Body Aspiration, Blood Gas, Bronchoscopy
Comparison of Patients With and Without Foreign Body Aspiration After Bronchoscopy.
To compare patients under 5 years of age with foreign body aspiration and without foreign body aspiration with radiological and blood gas results.
- Trial name
- NCT04467307
- Testing
- Rigit bronchoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Post-Acute COVID-19 Syndrome
Effect of Inhaled Hydroxy Gas on Long COVID Symptoms
The goal of this clinical trial is to see if several weeks of self-administered, home-based, treatment involving breathing hydroxy gas (a mixture of hydrogen and oxygen) for at least 2 hours a day for 3 weeks, will relieve…
- Trial name
- LCHydroxy (NCT06159296)
- Testing
- Hydroxy gas
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Oxford Brookes University
Ischemic Heart Disease
Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)
The purpose is to investigate how the adsorptive capacity of the active carbon filter to carbon dioxide in an anaesthetic gas reflector (AnaConDa) is affected by adding inhaled anaesthetic agent.
- Trial name
- NCT01699802
- Testing
- Inhaled anaesthetic agent
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Region Skane
General Anesthesia
Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas
This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor.
- Trial name
- NCT00532402
- Where
- 2 sites in Germany
- Volunteers
- 16 people
- Sponsor
- University of Luebeck
Lobotomy Syndrome
Acapella vs Flutter Devices for Improving Breathing and Lung Function After Lobectomy
Lobectomy patients frequently experience postoperative respiratory complications such as secretion retention, dyspnea, impaired gas exchange, and reduced lung function, which can delay recovery.
- Trial name
- NCT07737093
- Testing
- Acapella Device Therapy (Experimental Arm 1):, Flutter Device Therapy (Experimental Arm 2):
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Awareness, Anesthesia, Recall Phenomenon
Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique
Awareness during general anesthesia - that has an incidence between 0.1% and 0.9% of cases and may be more in elderly - remains a concern for anesthesiologists.
- Conditions
- Awareness, Anesthesia, Recall Phenomenon, Inhalation; Gas
- Trial name
- NCT05019560
- Testing
- Sevoflurane, TIVA
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Chronic Leg Ulcer
Efficacy of 50% Nitrous Oxide/50% Oxygen Gas Premix in Chronic Leg Ulcer Debridement
Adequate analgesia in serial chronic leg ulcer debridement can be difficult to achieve. A common analgesia method is the topical administration of local anesthetics directly onto the wound.
- Trial name
- NCT02696460
- Testing
- N2O/O2 analgesia, Lidocaine/Prilocaine analgesia
- Volunteers
- 21 people
- Sponsor
- Venenklinik Bellevue
Post Coronary Artery Bypass Grafting
Effectiveness of Incentive Spirometer and Diaphragmatic Breathing Exercise on ABG Measures in Post-CABG Patients
The rate of pulmonary complications following Coronary artery bypass graft (CABG) is high. Early pulmonary exercises are important in preventing this complication following cardiac surgery.
- Trial name
- NCT05684679
- Testing
- Incentive spirometer plus Chest physiotherapy, Diaphragmatic breathing exercise plus Chest physiotherapy
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- King Saud University
Covid19, Hydrogen-oxygen Gas
Hydrogen-oxygen Gas Mixture Inhalation in Patients With Convalescent Coronavirus Disease 2019 (COVID-19)
This study is a multicenter, randomized, open, parallel-controlled study. Qualified subjects will randomly be assigned to the experimental arm or the control arm according to the ratio of 1:1, with age (> 60 years or ≤ 60 years)…
- Conditions
- Covid19, Hydrogen-oxygen Gas, AMS-H-03
- Trial name
- NCT04594460
- Testing
- Hydrogen-Oxygen Generator with Nebulizer, AMS-H-03, OLO-1 Medical Molecular Sieve Oxygen Generator
- Where
- 2 sites in China
- Volunteers
- 198 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Avalanche Burial
Impact of CO2 Absorption on Gas Exchange and Ventilation Patterns While Breathing Into a Snow Air Pocket
Asphyxia is by far the most common cause of death after critical avalanche burial. The presence of an air pocket increases the survival chances, but expired air rich in carbon dioxide (CO2) progressively displaces oxygen (O2) in…
- Trial name
- AVACO2R (NCT06895759)
- Testing
- Soda lime
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Anesthesia
Comparison of Minimal Fresh Gas Requirements of Baby EAR and Jackson Rees Anesthetic Circuit
The investigators invented the baby enclosed afferent reservoir anesthesia circuit (Baby EAR) which could be used safely in children between 5 and 20 kg, using a fresh gas flow of 2.5 and 3 L/min in the spontaneous breathing and…
- Trial name
- NCT02167269
- Testing
- Baby EAR
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Khon Kaen University
Accident Caused by Snow Avalanche
Physiological Values When Breathing in an Air-pocket. Mountain Lab 2019 (ML2019)
The literature describes and report neurologic intact patients surviving an avalanche several hours after they were buried. The most important factor for surviving more than 15-35 min of burial is considered to be the presence of…
- Trial name
- NCT03911011
- Testing
- Fresh air
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Hearing Loss, Sensorineural
Hydrogen-oxygen Gas Mixture Inhalation in Patients With Sudden Sensorineural Hearing Loss
Idiopathic sudden sensorineural hearing loss (ISSHL) is defined according to American Academy of Otolaryngology as a hearing loss of at least 30 decibel over 3 contiguous test frequencies occurring within a 72h period.
- Trial name
- NCT04881435
- Testing
- Hydrogen gas therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (SARS-Cov-2) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
- Trial name
- NoCovid (NCT04305457)
- Testing
- Nitric Oxide
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital