Clinical trials: Inhalation
Healthy
Evaluation of Lung Deposition of Aerosol Via HFNC in Healthy Adults
The aerosol associated with noninvasive ventilation (NIV) and high flow therapy with nasal interface have been employed in an attempt to relieve respiratory distress and optimize the deposition of drugs by inhalation.
- Trial name
- NCT02519465
- Testing
- 10l/min, 30l/min, 50l/min
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Exercise Training, Respiratory Muscle Training
Effects of High Intensity Interval Training (HIIT) vs. Inspiratory Muscle Training on the Recovery After a Maximal Apnea.
The aim of this randomized cross-over controlled study was to assess the effects of an 4-week exercise program on the recovery capacity after a voluntary maximal apnea.
- Conditions
- Exercise Training, Respiratory Muscle Training, High-Intensity Interval Training, Apnea
- Trial name
- (HIIT) (NCT04084535)
- Testing
- High intensity interval training, Inspiratory muscle training
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Pulmonary Disease, Chronic Obstructive
Safety, Tolerability and Pharmacokinetics of GSK3923868 Inhalation Powder in Healthy Participants and Stable Asthmatics
This is a first time in human (FTIH) study designed to evaluate the safety, tolerability and pharmacokinetic (PK) profile of single and repeat doses of GSK3923868 inhalation powder in both healthy participants and asthmatics.
- Trial name
- NCT04585009
- Testing
- GSK3923868, Monodose RS01
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers
Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of HSK39004 Dry Powder Inhalation
To evaluate the safety, tolerability and pharmacokinetic characteristics of HSK39004 dry powder inhalation in healthy subjects.
- Trial name
- NCT06971198
- Testing
- HSK39004
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Dyspnea, Chronic Obstructive Pulmonary Disease
Menthol for Dyspnea Relief in Health and COPD
Menthol inhalation (MI) is a novel and promising treatment option for acute relief of dyspnea, however, the underlying ventilatory and/or neural related mechanisms for this relief in symptoms remain unknown.
- Trial name
- MENTHODYSC (NCT05785026)
- Testing
- Menthol inhalation, Strawberry scent, Menthol inhalation and facial airflow
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Lymphedema of Leg, Lymphedema
Inspiratory and Calf Muscles Training in Patients With Leg Lymphedema
Lymphedema results in the accumulation of protein-rich fluid in the subcutaneous tissue as a result of the failure of the lymphatic system, which returns water and protein in the interstitial spaces to the bloodstream.
- Conditions
- Lymphedema of Leg, Lymphedema, Exercise
- Trial name
- NCT05609526
- Testing
- Compression Therapy, Inspiratory muscle training, Calf muscle exercise training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Diaphragm Fatigue, Healthy
Inspiratory Resistive Loading and Diaphragm Fatigue
The aim of the study is to clarify whether specific loading of the inspiratory muscles induces contractile fatigue of the diaphragm muscle in healthy individuals and individuals with recurrent low back pain.
- Conditions
- Diaphragm Fatigue, Healthy, Low Back Pain
- Trial name
- NCT01505517
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Adolescent Development
Inspiratory and Expiratory Muscle Training in Adolescent Volleyball Players
This study will investigate the effects of inspiratory and expiratory muscle training on respiratory muscle strength, pulmonary function, and performance status in adolescent athletes
- Trial name
- NCT06759779
- Testing
- inspiratory muscle training, expiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Gazi University
Healthy, Healthy Adult
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in healthy individuals, who live permanently >2600m.
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801950
- Testing
- Descent from 2850m to sea level and re-ascent back to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Aspiration of Gastric Contents
Prophylaxis for Aspiration of Gastric Contents.
Effect of orally administered two equal and consecutive doses of proton pump inhibitors, omeprazole, lansoprazole, esomeprazole , rabeprazole and pantoprazole and Histamine 2 receptor antagonists cimetidine…
- Trial name
- NCT02703896
- Testing
- Drug either PPIS or H2RA and prokinetics, orogastric intubation
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- King Saud University
Healthy Volunteers
Assessment of 2 Different Techniques for Suppression of Respiratory Motion in Lung Cancer Treatment With Proton Therapy Using Magnetic Resonance Imaging (MRI)
Since 1996 proton therapy has been applied very successfully at the Paul Scherrer Institute in Switzerland to irradiate deep-seated, stationary tumors. In order to treat tumors within an organ which moves due to breathing (e.g.
- Trial name
- NCT03669341
- Testing
- Deep Inspiration Breath Hold (DIBH), High Frequency Percussive Ventilation (HFPV)
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Paul Scherrer Institut, Center for Proton Therapy
Airway Obstruction, Sedation Complication
Evaluation of Medical Device for Airway Patency During Sedation (SW01-2022)
The goal of this four-part preclinical [I-II] and clinical [III-IV] trial is to compare, with randomised crossover study design [I-IV], a new medical airway device with standard procedure (biteblock or no device) for upper airway…
- Conditions
- Airway Obstruction, Sedation Complication, Safety Issues, Patient Satisfaction
- Trial name
- NCT05708651
- Testing
- Investigational device [I-IV], Comparator [I-IV]
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Stairway Medical AB
Anesthesia, Hypoxia
Assessment of Preoxygenation Strategies in the Prehospital Environment
Comparison of the preoxygenation efficacy of tidal volume breathing using three different preoxygenation techniques which are available to providers in the prehospital environment.
- Trial name
- NCT02694705
- Testing
- Continuous Positive Airway Pressure (CPAP), Bag-Valve-Mask (BVM), Non-rebreather Mask (NRM)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Heparin
The Effect of Heparin on Inhalation Injury
This is a prospective randomized clinical trial about the efficacy of heparin nebulization on lung injury score in inhalation burn injury in Mothary burn hospital.
- Trial name
- NCT01454869
- Testing
- standard care, Heparin
- Where
- Iran
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Acute Mountain Sickness
Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude
In this investigation the researchers explore whether different types of breathing procedures can improve the peripheral oxygen saturation to reduce the risk of becoming a acute mountain sickness or a high altitude pulmonary…
- Trial name
- NCT01468194
- Testing
- Breathing procedure 1, Breathing procedure 2
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Healthy Volunteers
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MKND-201 in Healthy Volunteers
MKC-NI-001 is a Phase 1, first-in-human, randomized, double-blind, placebo-controlled study of nintedanib inhalation powder (MNKD-201) in healthy adult volunteers.
- Trial name
- NCT06532942
- Testing
- (Part A) MKND-201, (Part B) MKND-201
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation
Ventilation, Reproducibility
Assessing Variability of the Ventilatory Response to Duffin's Rebreathing Procedure
This study will combine Duffin's rebreathing procedure with additional study procedures, such as quantitative pupillometry, that are planned for subsequent clinical studies in order to confirm feasibility and gather…
- Conditions
- Ventilation, Reproducibility, Physiology
- Trial name
- NCT05168501
- Testing
- Rebreathing procedure
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
UPPER CROSS SYNDROME
Effects of Segmental and Pursed Lip Breathing Exercises on Upper Cross Syndrome
Upper cross syndrome is relative prevalent 67% musculoskeletal disorder among general population due to increased usage of smart gadgets and poor postural habits.
- Trial name
- NCT06303102
- Testing
- Manual PT/ Conventional PT Treatment + Segmental and Pursed Lip Breathing Exercise, Manual PT/Conventional PT Treatment
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Mouth Breathing
Posture and Pulmonary Function of Mouth-breathing Children
The purpose of this study is to characterize the posture and respiratory function of mouth-breathing children.
- Trial name
- NCT01019525
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Respiratory Muscles, Breathing Exercises
Inspiratory Muscle Training in Wheelchair Basketball Players
Investigate the effects of Inspiratory Muscle Training on the physical performance and cardiorespiratory variables of wheelchair basketball players.
- Conditions
- Respiratory Muscles, Breathing Exercises, Athletic Performance, Athletes
- Trial name
- NCT02604147
- Testing
- Inspiratory pressure-threshold muscle training device., nspiratory pressure-threshold muscle training device.
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
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