Clinical trials: Inhalation
Idiopathic Pulmonary Fibrosis
Study of ARO-MMP7 Inhalation Solution in Healthy Participants and Participants With Idiopathic Pulmonary Fibrosis
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of ARO-MMP7 in normal healthy volunteers (NHVs) and in participants with idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT05537025
- Testing
- ARO-MMP7 Inhalation Solution
- Where
- 19 sites in Denmark, Italy and 4 more
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals
Nursing Personnel
The Effect of Essential Oil Inhalation Patches on Perceived Burn-out & Stress on an Inpatient Medical-surgery Unit.
The purpose of this clinical study is to compare the use of an essential oil inhalation patch in medical surgical nurses on perceived burn-out and stress.
- Trial name
- NCT06053450
- Testing
- Oil Inhalation Patch
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Abuse Liability of Staccato Alprazolam
Staccato Alprazolam Abuse Liability
Compare the abuse liabilities of Staccato Alprazolam, oral immediate-release alprazolam, and Staccato Placebo.
- Trial name
- NCT00603980
- Testing
- Inhaled alprazolam 0.5 mg, Inhaled alprazolam 1 mg, Inhaled alprazolam 2 mg
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Nova Pneuma Inc.
Healthy
Suitability of a Low Dose Lipopolysaccharide (LPS) Inhalation as a Challenge Model
This pilot study is planned to assess the suitability of a low dose Lipopolysaccharide (LPS) inhalation as a challenge model. As LPS effects are based on a different mode of action, this challenge model will provide the…
- Trial name
- NCT01400568
- Testing
- LPS challenge with nebulized LPS, fluticasone propionate (FP)
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Hypoxemia, Altitude Hypoxia
Effects of Continuous Positive Airway Pressure on Peripheral Oxygen Saturation, Work of Breathing, and Exercise Tolerance at Altitude
Dyspnea and exercise intolerance are well known to travelers who have experienced time at high elevations, greater than 2500 meters (8200 feet).
- Trial name
- NCT05971290
- Testing
- Continuous positive airway pressure, Ambient air
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Respiratory Monitoring
Human Electrical-Impedance-Tomography Reconstruction Models
Current EIT analyses are based on the assumption of a circular thorax-shape and do not provide any information on lung borders. The aim is to obtain the body and lung border contours of male subjects by multi-detector computed…
- Trial name
- NCT02773680
- Testing
- "electrical impedance tomography"
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dental Anxiety
To Assess Breathing Exercise as a Relaxation Method
in this study investigator evaluate the effectiveness of breathing exercise using two different play toys in reducing dental anxiety.
- Trial name
- NCT06698523
- Testing
- Breathing exercise, Deep breathing
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Breakthrough Pain
Staccato Fentanyl Single and Multidose PK
The Phase I clinical trial in approximately 50 healthy volunteers will be conducted at a single clinical center in two stages. Stage 1 is an open-label, cross-over comparison of a single dose of Staccato Fentanyl and an…
- Trial name
- NCT00402350
- Testing
- Inhaled Fentanyl 25 mcg, Intravenous Fentanyl 25 mcg, Inhaled Fentanyl 25 mcg x 2
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Healthy Volunteers
Development of Hardware and Software for Pulmonary Magnetic Resonance Imaging Using Inhaled Tracer Gases
This is a single centre study. The overarching hypothesis of this study is that MRI with inhaled tracer gases can provide high quality images of lung function to complement conventional 1H MRI.
- Trial name
- NCT04726618
- Testing
- Hyperpolarized 129-xenon gas and Perfluoropropane gas
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Post-Acute Sequelae of COVID-19
Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD)
Diaphragm is the principal muscle of inspiration. Diaphragmatic dysfunction is seen in many conditions including following intubation, lung disease, prolonged ventilation, neuromuscular disease, phrenic nerve injury.
- Trial name
- NCT06330376
- Testing
- Usual care of traditional treatment, Specific DB program/Diaphragmatic manipulation program
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Breathing Exercises, Critical Care Nursing
The Effect of Breathing Exercise Applied to Intensive Care Nurses on Fatigue and Perceived Stress
The aim of this randomized controlled trial was to investigate the effect of breathing exercise on fatigue and stress in intensive care nurses.
- Trial name
- NCT06642376
- Testing
- Experimental: Breathing Exercise Application Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kahramanmaraş İstiklal University
Smokers
Acute IMT Intensity Effects in Male Smokers
Acute IMT Intensity Effects in Male Smokers
- Trial name
- NCT07200895
- Testing
- Inspiratory Muscle Training (30% MIP), Inspiratory Muscle Training (60% MIP)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- FATMA DİLARA AKAR ÇAMYAR
COVID-19
The Safety, Tolerability, and Pharmacokinetics of Inhaled TLC19 in Healthy Volunteers
Phase 1 randomized, vehicle-controlled, blinded study to assess the safety, tolerability, and PK of single ascending doses of inhaled TLC19 in healthy volunteer subjects.
- Trial name
- NCT04697654
- Testing
- TLC19, TLC19 Vehicle
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taiwan Liposome Company
Systemic Lupus Erythematosus
Respiratory Function, Physical Activity and Fatigue in SLE
Increasing awareness of possible pulmonary involvement in patients with systemic lupus erythematosus (SLE) will enable earlier diagnosis of the disease and minimize damage accumulation.
- Trial name
- NCT07193745
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Melis Usul
Symptoms of Inhalational Anthrax
Safety and Pharmacokinetic Study of Anthrax Immune Globulin Derived From Human Serum
The purpose of the study is to assess the pharmacokinetics of three doses of NP-015 (210, 420 or 840 units TNA) in healthy volunteers. To evaluate the safety of NP-015 based on adverse events and laboratory assessments.
- Trial name
- NCT00448253
- Testing
- NP-015
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Low Back Pain, Sleep Hygiene
The Effect of Breathing Exercise and Stabilization Exercise With Chronic Low Back Pain
The aim of this study is to compare the effect of sleep hygiene, breathing exercises, and stabilization exercises on pain, sleep quality, and anxiety level in patients with non-specific chronic low back pain.
- Conditions
- Low Back Pain, Sleep Hygiene, Anxiety
- Trial name
- NCT05212753
- Testing
- Conventional physical therapy, Lumbar stabilization exercises, Breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Sleep
Influence of Yogic Breathwork on Sleep
The purpose of this research study is to determine the influence of a regular yogic breathing practice on sleep, and to find out primarily if a regular practice of 8-week yogic breathing would enhance sleep quality as well as if…
- Trial name
- NCT05756686
- Testing
- Breathing Group 1, Breathing Group 2
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
COVID-19
Inhaled Ivermectin and COVID-19
Coronavirus disease-19 is global healthcare crisis. Till May 20, 2020, there were approximately 4,789,205 cases and 318,789 related mortalities were identified globally.
- Trial name
- CCOVID-19 (NCT04681053)
- Testing
- Ivermectin Powder
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Oxidative Stress, Anesthesia
Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia
Total intravenous anesthesia (TIVA) and inhalation anesthesia are two anesthesia methods that can be preferred for the maintenance of anesthesia. Sevoflurane and propofol are drugs used frequently in these methods.
- Trial name
- NCT04310748
- Testing
- Total Intravenous Anesthesia(TIVA), Inhalation Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Asthma
The Asthma Bronchial Challenge Study
This is a randomised, controlled, cross-over study to determine the effect of indirect bronchial challenge testing upon volatile organic compounds (VOCs) in the exhaled breath of adults with well-controlled, mild-to-moderate…
- Trial name
- ABC (NCT03575663)
- Testing
- Indirect bronchial challenge
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
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