Clinical trials: Inhalation
Healthy Volunteers
A Phase I, Open-Label, Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Aclidinium Bromide in Healthy Chinese Participants
A Phase I, single centre, open-label study to investigate the pharmacokinetics (PK), safety and tolerability of single and multiple twice daily doses of inhaled Aclidinium Bromide in healthy Chinese male and female subjects.
- Trial name
- NCT03276052
- Testing
- Aclidinium Bromide 400 μg
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Migraine Headache, With or Without Aura
Staccato Prochlorperazine in Migraine (in Clinic)
Development of Staccato Prochlorperazine for the treatment of migraine headache.
- Trial name
- NCT00610428
- Testing
- Staccato Prochlorperazine 5 mg, Staccato Prochlorperazine 10 mg
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Forward Head Posture
Effect of Posture and Breathing Exercises in Forward Head Posture
This study aims to compare the effects of postural exercises with and without breathing exercises in the subjects having forward head posture.
- Trial name
- NCT06197919
- Testing
- postural exercises, postural exercises with breathing exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Obstructive Apnea, Sleep Apnea Syndrome, Obstructive
Pilot Study of Negative Pressure Neck Therapy (NPNT)
Obstructive sleep apnea (OSA) is a serious, chronic sleep-related breathing disease in which the upper airway repeatedly collapses during sleep, leading to intermittent oxygen deprivation.
- Conditions
- Obstructive Apnea, Sleep Apnea Syndrome, Obstructive, Sleep Disorder (Disorder)
- Trial name
- NCT07301567
- Testing
- Negative Pressure Neck Therapy (NPNT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Primary Dysmenorrhea
Combined Effects of Kegel Exercises and 4-7-8 Breathing Technique in Primary Dysmenorrhea
A randomized clinical trial will be conducted at Riphah International University QIE Campus in Lahore, using non-probability convenience sampling with 28 participants.
- Trial name
- NCT06339918
- Testing
- KegelExercise, 4-7-8 breathing technique
- Where
- Pakistan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Low Back Pain, Respiratory Loading
Inspiratory Resistive Loading and Proprioceptive Postural Control
Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance.
- Conditions
- Low Back Pain, Respiratory Loading, Proprioceptive Impairment
- Trial name
- NCT01541020
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KU Leuven
General Anesthesia, İnhalation Anesthetics
Effects of Anesthesia Type on QoR-40
To compare the effects of total intravenous anesthesia and inhalation anesthesia used for maintenance on postoperative recovery in patients undergoing septorhinoplasty surgery under general anesthesia, using the recovery quality…
- Conditions
- General Anesthesia, İnhalation Anesthetics, Quality of Recovery
- Trial name
- NCT06423313
- Testing
- maintenance of anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Chronic Obstructive Pulmonary Disease (COPD), COPD
Evaluation of the Absolute Bioavailability and Mass Balance of CHF6001 (Tanimilast) in Healthy Subjects
The objective of the study is to evaluate the bioavailability of CHF6001 after inhaled administration, to characterize the mass balance and route of elimination of CHF6001 along with its relevant metabolites, in healthy male…
- Trial name
- NCT04756960
- Testing
- CHF6001
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Healthy
Safety, Tolerability and Pharmacokinetics of BEA 2180 BR in Healthy Male Volunteers
Evaluation of safety, tolerability and pharmacokinetics of single rising intravenous doses of BEA 2180 BR; additional exploration of metabolism following inhalation
- Trial name
- NCT02254720
- Testing
- BEA 2180 BR solution for infusion, BEA 2180 BR solution for inhalation, Respimat®
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Asthma, Healthy Volunteers
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of RV1729 for up to 28 Days
RV1729 is a new medicine being developed for the potential treatment of asthma and smoking related lung disease (also known as chronic obstructive pulmonary disease - COPD).
- Trial name
- NCT02140320
- Testing
- RV1729 single dose, RV1729 14 day repeat dose, RV1729 28 day repeat dose
- Where
- 2 sites in United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Respivert Ltd
Covid19
Use of Inhaled High-molecular Weight Hyaluronan in Patients With Severe COVID19: Feasibility and Outcomes
To determine whether inhaled Yabro protects against progression of COVID19-induced respiratory failure preventing the passage to non-invasive ventilation (NIV) and promotes recovery from COVID19 lung disease in hospitalized…
- Trial name
- HA-COVID (NCT04830020)
- Testing
- HMW-HA
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Campus Bio-Medico University
Pulmonary Disease, Covid19
Effects of Using Mask During the 6-minute Walking Test in Times of COVID-19
Since the beginning of the pandemic caused by SARC-CoV 2, more than 81 million cases have been diagnosed and caused around 1,7 million deaths. Currently, a drug is being sought for the treatment of coronavirus.
- Conditions
- Pulmonary Disease, Covid19, Physical Disability
- Trial name
- NCT04789603
- Testing
- 6-min-walk surgical mask, 6-min-walk Fpp2, 6-min-walk without mask
- Where
- 2 sites in Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Occupational Burnout, Work-Related Stress
Virtual Mindfulness and Breathing Training for Stress, Burnout, Sleep, and Cognition in Rotating-Shift Nurses
This randomized controlled trial aims to evaluate the effectiveness of a mobile- and virtual reality-based mindfulness and breathing intervention on stress, burnout, sleep quality, and cognitive function among Rotating-shift…
- Conditions
- Occupational Burnout, Work-Related Stress, Sleep Disturbance, Cognitive Dysfunction
- Trial name
- NCT07028788
- Testing
- Health Education Material, Mobile-Based Mindfulness, Mobile-Based Mindfulness combined with Breathing
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Shih-Chin
Heated Tobacco, Respiratory Function
Acute Effects of a Heat-not-burn Tobacco Product on Pulmonary Function in Healthy Non Smokers.
IQOS ("I-Quit-Ordinary-Smoking,") is a type of "heat-not-burn" (HNB) tobacco product. There is evidence of a growing number of young people who try IQOS as a 'safe' alternative of cigarette.
- Conditions
- Heated Tobacco, Respiratory Function, Tobacco Toxicity
- Trial name
- NCT03995329
- Testing
- IQOS
- Where
- 2 sites in Greece
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Liver Diseases
Liver Fat and Iron Quantification MRI
The objective of this study is to develop and evaluate novel magnetic resonance imaging (MRI) protocols for studying the structure and function of the human body using 1.5 Tesla and 3.0 Tesla MRI scanners with or without the use…
- Trial name
- NCT03162302
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sleep Apnea Syndromes
Snoring in Pregnancy and Adverse Maternal and Fetal Outcomes
The purpose of the study is to determine the prevalence of sleep-disordered breathing in pregnant women during the third trimester of pregnancy and to investigate whether this is associated with high blood pressure in the mother…
- Trial name
- NCT01030003
- Where
- United States
- Volunteers
- 1,685 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Patient Compliance, Inhalation Spacers
Animated Cartoons and Cooperation in Young Children Receiving Inhaled Medications
Up to 50% of infants and young children cry during the administration of their inhaled treatment for their asthma. This results in decreased lung deposition, and thus decreased effectiveness of their inhaled treatment.
- Trial name
- DISTRACT (NCT02879240)
- Testing
- Animated Cartoon, Black screen
- Where
- 3 sites in France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Hôpital Necker-Enfants Malades
Gastrointestinal System--Abnormalities, Anxiety
Four-week Breathing Interventions on Gut Symptoms, Heart Rate Variability, and Psychological Measures in Runners
Recent research has suggested that stress and anxiety levels are associated with gastrointestinal (GI) symptoms in endurance athletes (runners, cyclists, triathletes).
- Conditions
- Gastrointestinal System--Abnormalities, Anxiety, Visceral Pain
- Trial name
- NCT04592718
- Testing
- Slow deep breathing plus breath counting, Normal-paced breathing plus breath counting
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Old Dominion University
Asthma
Study of ARO-RAGE in Healthy Subjects and Patients With Inflammatory Lung Disease
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of ARO-RAGE in normal healthy volunteers (NHVs) and in participants with inflammatory lung disease (asthma).
- Trial name
- NCT05276570
- Testing
- ARO-RAGE
- Where
- 8 sites in Australia, New Zealand and 3 more
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Arrowhead Pharmaceuticals
Healthy, Healthy Smoker
Inhaled RB042 in Healthy Adult Volunteers, Healthy Adult Smokers and Patients With Chronic Obstructive Pulmonary Disease
This is a 4-part, randomised, double-blind, placebo-controlled, first in human study evaluating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of inhaled RB042.
- Conditions
- Healthy, Healthy Smoker, COPD (Chronic Obstructive Pulmonary Disease), COPD
- Trial name
- NCT07285122
- Testing
- RB042
- Where
- Australia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Atisama Therapeutics
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