Clinical trials: Inhalation
Healthy Volunteers, Drug Delivery Systems
Validation of Safety and Performance of Three EDDIS Breath-Activated Portable Inhalation Systems
This is a crossover study to evaluate real-time performance, airflow control, user-device interaction, and safety systems of three portable inhalation systems from the EDDIS platform.
- Conditions
- Healthy Volunteers, Drug Delivery Systems, Inhalation of Liquid Air, Administration Site Injury
- Trial name
- EDDIS-ENG (NCT06902129)
- Testing
- EDDIS Platform - Portable Inhalation Delivery Systems (VMT, Atomizer, Ultrasonic)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Petrov, Andrey
Accident Caused by Snow Avalanche
Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency
The aim of the study is to investigate Work of Breathing of a person in simulated avalanche snow and consequent use of the measured data for judging which one of three simulated scenarios are alike while increasing hypercapnia in…
- Trial name
- NCT04835545
- Testing
- extreme hypercapnia induced by ventilation insufficiency
- Where
- Czechia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Respiratory Complication, Cardiac Disease
Active Cycle Breathing Technique (ACBT) on Respiratory Parameters, Dyspnea Related Kinesiophobia and Pain
This study aims to improve pulmonary function impairment is associated with a reduction in chest expansion, lung volume, pain perception and an impairment of the Post cardiac surgery patient's ability to cough effectively.
- Trial name
- (ACBT) (NCT06521346)
- Testing
- Active cycle breathing technique, Routine care
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Cancer
Impact of Continuous Positive Airway Pressure on Breathing Motion Amplitude
This study involves a breathing motion assessment in healthy subjects before and after continuous positive airway pressure (CPAP) administration using MRI images.
- Trial name
- NCT02852473
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Inhalation Anesthesia, Dexmedetomidine
The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE)
Sevoflurane is a volatile agent easy to control thanks to the Minimum Alveolar Concentration (MAC) allowing its titration for an optimal depth of anesthesia.
- Conditions
- Inhalation Anesthesia, Dexmedetomidine, Sevoflurane, Laparoscopy
- Trial name
- NCT05615194
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Influenza
Influenza Antiviral DAS-181-F04 in Healthy Adults
This study will be a double-blind, randomized, placebo-controlled study of a single dose (20mg) of Influenza Antiviral DAS181-F04 for 3 days.
- Trial name
- NCT01651494
- Testing
- DAS181
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteers
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of C16TR for Inhalation With Tyvaso® Cohort in Healthy Participants
The primary purpose of this study is to determine the safety and tolerability of escalating doses of C16TR for inhalation in healthy participants.
- Trial name
- NCT06193031
- Testing
- C16TR, Tyvaso®
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Inhalation Anesthesia
Comparing Nebulized Ketamine,Nebulized Ketamine and Precedex and IM Ketamine for Analgesia in Pediatric Burn
The present study compares efficacy of nebulised ketamine and combination of nebulised dexmedetomidine and ketamine and intramuscular ketamine for procedural sedation and analgesia in pediatric burn injuries
- Trial name
- NCT07086690
- Testing
- Group (1): Patients will receive nebulized ketamine (2 mg/kg), Group (2): Patients will receive nebulized combination of dexmedetomidine and ketamine (1 μg/kg + 1 mg/kg), Patients will receive intramuscular ketamine (4 mg/kg, intramuscularly) 15 mins before starting the procedure.
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy
AZD2115 Multiple Ascending Dose Study
This study will investigate the safety and tolerability of AZD2115 following administration of multiple ascending doses.
- Trial name
- NCT01445782
- Testing
- AZD2115
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Coronary Artery Stenosis
Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)
The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.
- Trial name
- B-MORE (NCT04126148)
- Where
- 8 sites in United States, Australia and 5 more
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Matthias Friedrich
Chronic Obstructive Pulmonary Disease
Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease (COPD)
Human and animal studies have shown that inhaled corticosteroids (ICS) decrease airway blood flow . This effect is immediate (within 30 minutes), transient (lasting 90 minutes), and in animal studies independent of gene…
- Trial name
- NCT00202189
- Testing
- Budesonide
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Queen's University
Healthy
Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With Two Reference Products
The purpose of this study is to compare the absorption of three different inhalation products with the reference products in healthy volunteers.
- Trial name
- NCT02627625
- Testing
- Tiotropium
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Preoperative Anxiety (Ameliyat Öncesi Anksiyete), Emergence Delirium (Derlenme Deliryumu)
Preoperative Gamified Breathing Exercise on Anxiety and Delirium in Children.
This study aims to evaluate the effect of preoperative gamified breathing exercises on preoperative anxiety and postoperative emergence delirium in children. The intervention includes games like ball blowing and bubble blowing.
- Conditions
- Preoperative Anxiety (Ameliyat Öncesi Anksiyete), Emergence Delirium (Derlenme Deliryumu), Postoperative Complications, Pediatric Patients
- Trial name
- PED-ANX-DEL (NCT07408037)
- Testing
- Gamified Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bozok University
Airway Deadspace
Airway Deadspace in Children: Air-Q Versus Endotracheal Tube
The objective of this study will be to measure the airway deadspace associated with use of appropriately sized an AirQ, a commonly used supraglottic airway in young children weighing between 5 and 20 kg and compare that to the…
- Trial name
- NCT03785977
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Asthma
The Use of the Propeller Health Platform to Improve Inhaled Corticosteroid (ICS) Use Among Adults With Uncontrolled Persistent Asthma
This is a behavioral randomized controlled trial of adults with uncontrolled persistent asthma that tests if the Propeller Health sensor, mobile application, and dashboard can improve adherence to ICS.
- Trial name
- NCT03860519
- Testing
- Electronic Medication Monitors on ICS and SABA - Active Mode, Electronic Medication Monitors on ICS and SABA - Silent Mode, Asthma App Tracking of ICS/SABA Usage - Active Mode
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Healthy
Flow Proportional Pressure Support in Volunteers
Flow proportional pressure support (FPPS) is a new mode of spontaneous breathing assistance. In patients with increased respiratory resistance the role of FPPS in comparison with the pressure support assist breathing mode is…
- Trial name
- NCT00866541
- Testing
- artificial increased resistance (flow proportional pressure support)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Dental Pain, Muscle Sensitivity to Pressure
Analgetic Effect of Nitrousoxide-oxygen Inhalation for Dental Treatment of Children
To assess the analgetic effect of nitrousoxide-oxygen inhalation on pain perception in 12-15 years old children from 1) the dental pulp; 2) the masseter muscle; 3) the skin on the upper lip
- Conditions
- Dental Pain, Muscle Sensitivity to Pressure, Skin Sensitivity to Electric Stimulation
- Trial name
- NCT01022294
- Testing
- Nitrousoxide-oxygen and atmospheric air, Atmospheric air; nitrousoxide-oxygen
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension Disorders in Pregnancy, Blood Pressure Measurement in Pregnancy
Breathing for Two: Inspiratory Muscle Strength Training for Supporting Healthy Blood Pressure in Pregnancy
This is an interventional study that will test whether a breathing exercise called Inspiratory Muscle Strength Training (IMST) can safely and effectively lower blood pressure during late pregnancy.
- Conditions
- Hypertension Disorders in Pregnancy, Blood Pressure Measurement in Pregnancy, Inspiratory Strength Training (IST), Pregnancy
- Trial name
- NCT07687745
- Testing
- Exercise at 15% PI max, Exercise at 50% PI max
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Tuberculosis
Safety of Tuberculosis Vaccine, MVA85A, Administered by the Aerosol Route and the Intradermal Route
This is a phase I trial to compare the safety and immunogenicity of candidate TB vaccine MVA85A administered by the aerosol inhaled route and the intradermal route in healthy BCG-vaccinated adult subjects.
- Trial name
- NCT01497769
- Testing
- Aerosol inhaled MVA85A, Intradermal MVA85A
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Gynecologic Nursing, Postoperative Pain
Shoulder Pain and Post Gynecologic Laparoscopic Recovery
The present study aims to investigate the effect of postoperative trendelenburg position versus warm pad application and deep breathing technique on shoulder pain intensity and post gynaecologic laparoscopic recovery
- Trial name
- NCT05344677
- Testing
- Trendelenburg Position, Warm Pad Application, Deep Breathing Exercise
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
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