Clinical trials: Inhalation
Anaphylactic Reaction
Study of Inhaled Epinephrine and Intramuscular Epinephrine Administered to Healthy Adults
This is a study to determine the relative bioavailability of inhaled epinephrine compared with 0.3mg epinephrine administered IM in healthy male and female participants.
- Trial name
- NCT05152901
- Testing
- EpiPen ®., Epinephrine (0.3mg) inhaled, Epinephrine (1.3mg)
- Where
- Australia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- De Motu Cordis
Endothelial Dysfunction
Effects of Carbon Monoxide Breathing on Blood Vessel Function
In healthy young adults 18-39 years of age, the investigators will determine if intermittent inhalation a 0.1% CO, from a 1-liter bag once every minute for 30-40 minutes, at a level that approaches the CO boost with hookah…
- Trial name
- NCT03067701
- Testing
- Carbon Monoxide
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Overweight and Obese, Young Adult
Effects of Kettlebell Swing Training Combined With Breathing Exercises on Respiratory Muscle Strength and Pulmonary Function in Overweight and Obese Young Adults
Overweight and obesity are associated with impaired breathing mechanics, including reduced chest wall and diaphragmatic movement, decreased respiratory muscle strength and endurance, and inefficient breathing patterns.
- Trial name
- Kettlebell (NCT07802080)
- Testing
- Kettlebell swing training, Control
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Phayao
Testing, Performance
Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections.
Malaria, schistosomiasis and ancylostomiasis are three parasitic diseases which affect hundreds of millions of people and are an important cause of global mortality and morbidity.
- Conditions
- Testing, Performance, Specificity, Sensitivity
- Trial name
- INSPiRED-WP3 (NCT04505046)
- Where
- Gabon
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
SDB, T2DM
Sleep Disordered Breathing and Impaired Glucose Homeostasis in Obese Children
SDB has been identified as an important risk factor for insulin resistance and the metabolic syndrome. In a recent study in patients with SDB and T2DM it was shown that CPAP therapy can lead to improvements in postprandial…
- Conditions
- SDB, T2DM, Obesity
- Trial name
- NCT02037100
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 2 of 7)
NOTE: This is the second of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882529
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Pharmacokinetics
Single-dose AQ001S PK Study in Healthy Volunteers
This is a randomized, open label, single-center, single-dose, four-period crossover clinical study to assess the pharmacokinetic profile and safety of a budesonide inhalation solution (AQ001S) compared to a budesonide inhalation…
- Trial name
- BORA (NCT05148312)
- Testing
- Budesonide Inhalant Product
- Where
- Bulgaria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Aquilon Pharmaceuticals S.A.
Pregnancy
The Effectiveness of The Breathing Exercise On The Nausea, Vomiting And Breathing Exercise In Pregnancy
Aim: This study aimed to investigate the effectiveness of the breathing exercise on pregnancy-related nausea and vomiting and the quality of life in the early pregnancy period.
- Trial name
- NCT05780112
- Testing
- breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Inonu University
Hyperoxemia, Intraoperative Oxygen Therapy
Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position
This study aims to evaluate whether guidance by the Oxygen Reserve Index (ORi) improves inspiratory oxygen fraction (FiO₂) titration compared with conventional pulse oximetry (SpO₂)-guided oxygen administration in adult patients…
- Conditions
- Hyperoxemia, Intraoperative Oxygen Therapy, Beach Chair Position, Cerebral Oxygenation
- Trial name
- ORI-BCP (NCT07404267)
- Testing
- ORi-Guided FiO₂ Titration, SpO₂-Guided FiO₂ Titration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Obesity
Flintstone Foods 1
This exploratory study is designed to compare the gastric layering and rates of emptying and by inference rates of digestion of a Palaeolithic inspired meal and a reference meal.
- Trial name
- NCT01925053
- Testing
- PAL meal, REF meal
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Respiratory Distress Syndrome (RDS), PreTerm Neonate
Breathing Patterns in Infants Before and After Extubation
The primary objective of this study is to compare work of breathing indices before and after extubation in intubated premature infants admitted to the Christiana Care Neonatal Intensive Care Unit.
- Trial name
- NCT07542301
- Testing
- Observation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
COPD
Human Safety of Capsaicin Inhalation Challenge Testing for Young and Older Men
In 2004, the investigators initiated a human Capsaicin inhalation experiment under an Investigational New Drug (IND) protocol approved by the FDA (IND 69,642) and the subject safety procedures instituted and approved by the…
- Trial name
- Capsaicin (NCT01621685)
- Testing
- biological/vaccine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Adult Subject
Effect of Super-Oxygenated Water on Blood Oxygen Saturation
Therapeutic delivery of additional Oxygen to blood stream via hyperbaric and extracorporeal oxygenation that raises blood Oxygen saturation level, apart from oxygenation in the lungs, is known to induce tissue repair, restore…
- Trial name
- NCT07016191
- Testing
- Ingestion of Water
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inhale, Inc
Healthy
Use of Fitbits During Breathing Meditation
This study will examine short breathing meditations paired with Fitbit technology in order to assess mindfulness and track physical activity.
- Trial name
- NCT05101343
- Testing
- Breathing meditation
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Winthrop University
Chronic Obstructive Pulmonary Disease (COPD)
Single Dose Lipopolysaccharide (LPS) Study In Healthy Volunteers
A single dose study with the inhaled anti-inflammatory agent PF-03715455 to establish if it has anti-inflammatory activity following a challenge with LPS.
- Trial name
- NCT01314885
- Testing
- PF-03715455, PH-797804
- Where
- 2 sites in United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pfizer
Labor Pain, Labor Onset
The Effects of Breathing Exercises and Virtual Reality Applications During Pregnancy and Labor.
Aim and Objectives: The purpose of this study was to determine the effects of breathing exercises and virtual reality applications during pregnancy and labor on labor pain, duration, and birth satisfaction.
- Conditions
- Labor Pain, Labor Onset, Patient Satisfaction, Virtual Reality
- Trial name
- NCT05527236
- Testing
- Breathing Exercise, Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Semra Çevik, phD
Healthy
Efficiency of Inspiratory Muscle Training in Elderly People
Efficiency of inspiratory muscle training in elderly people. Outcomes are lung function, muscle strength and chest expansion.
- Trial name
- NCT02424981
- Testing
- Threshold inspiratory muscle training
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Obstructive Pulmonary Disease
Exhaled Breathing Condensate (EBC) Features and Lung Function Decline in Chinese Adults
Chronic obstructive lung disease (COPD) is a worldwide leading and still increasing cause of chronic morbidity and mortality. The important issue of COPD is its delayed diagnosis.
- Trial name
- NCT02037828
- Where
- China
- Volunteers
- 2,440 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Pulmonary Arterial Hypertension, Interstitial Lung Disease
A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary Hypertension
The purpose of this research study is to find out more about the drug treprostinil via inhaler and the mechanisms of why patients with pulmonary arterial hypertension related to Interstitial Lung disease (PAH-ILD) have…
- Conditions
- Pulmonary Arterial Hypertension, Interstitial Lung Disease, Healthy Adults
- Trial name
- NCT05564637
- Testing
- Treprostinil, Right Heart Catheterization (RHC) while exercising, Optional Muscle Biopsy
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthcare Workers, Stress Level
Effects of VR-based Respiratory Training on Motor Reaction Time and Correctness, Stress Levels, Attention, Motor Skills, Postural Stability and Sleep Quality in Shift Healthcare Workers
This study investigates the effects of virtual reality (VR)-based respiratory training on various physiological and cognitive functions in shift-working healthcare professionals, including paramedics and nurses.
- Conditions
- Healthcare Workers, Stress Level, Emergency Department, Shift Work Sleep Disorder
- Trial name
- NCT06926257
- Testing
- Experimental group (B) - breathing training using VR, Experimental group (C) - breathing training using relaxation music
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
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