Clinical trials: Inhalation
Asthma
A Drug Interaction Study With Fluticasone Furoate/GW642444 Inhalation Powder and Ketoconazole
A randomized two-way crossover study to determine whether concomitant administration of CYP P450 3A4 inhibitor ketoconazole and fluticasone furoate/GW642444M combination significantly increases the systemic effects and exposure…
- Trial name
- NCT01165125
- Testing
- FF / GW642444, ketoconazole
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hypertension
Reduced Volume of Inspiratory Resistance Training
This clinical research study will investigate the dose of inspiratory muscle strength training needed to maintain cardiovascular adaptations induced by a six-week loading dose.
- Trial name
- REVIRT (NCT05744817)
- Testing
- Inspiratory muscle strength training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Posture
The Effect of Inspiratory Muscle Strength Training in Healthy Adults With Forward Head Posture
Forward head posture (FHP) is defined as the position in which the head is in front of the shoulder and is one of the most common musculoskeletal problems caused by the increasing use of computers and smartphones.
- Trial name
- NCT06519825
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Preoxygenation
Verbal Breathing Coaching to Improve Preoxygenation and Extend Safe Apnea Time in Anesthesia
This study explores whether simply guiding patients to breathe slowly and calmly before anesthesia can help improve oxygen levels and keep them safe for longer during induction.
- Trial name
- NCT07565259
- Testing
- Verbal Breathing Coaching
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prince Sultan Military Medical City
Postpartum Anxiety, Exercise Overtraining
Core Exercise and Early Postpartum
This study aimed to investigate the positive effects of abdominal core exercises and deep breathing exercises on abdominal muscle strength, pulmonary function, fatigue, and quality of life in the early postnatal period (1-6…
- Conditions
- Postpartum Anxiety, Exercise Overtraining, Fatigue
- Trial name
- NCT06704568
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara University
Obesity
The Influence of Inspiratory Muscular Training (IMT) on Diaphragmatic Mobility in Morbidly Obese
The purpose of this study is whether an inspiratory muscle training protocol would be associated with an improvement in of the diaphragm mobility, an increase in pulmonary function values , gain strength and endurance of…
- Trial name
- NCT01449643
- Testing
- Threshold
- Where
- Brazil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Pregnancy Related
Response of Pulmonary Functions to Deep Breathing Exercise in Twin Pregnancy
this study is to investigate the response of pulmonary function to deep breathing exercise in twin pregnancy
- Trial name
- NCT06031220
- Testing
- deep breathing exercise inform of diaphragmatic and costal breathing
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Badr University
Acute Lung Injury (ALI) Due to Coronavirus Disease-2019 (COVID-19)
TD-0903 Pharmacokinetics Study in Healthy Participants With Supplemental Oxygenation
This is a Phase 1 pharmacokinetic (PK) study in healthy participants to assess the plasma pharmacokinetics, safety, and tolerability of a single inhaled dose of nezulcitinib (TD-0903) with supplemental oxygenation.
- Trial name
- NCT05091723
- Testing
- Nezulcitinib (TD-0903) Dose A, Nezulcitinib (TD-0903) Dose B
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Prostate Cancer
A Comparison of Totally Intravenous and Inhalation Anesthesia for Intraocular Pressure During Robot-Assisted Laparoscopic Radical Prostatectomy
Robot-assisted laparoscopic radical prostatectomy (RALRP) has gained popularity during the past decade and has widely replaced conventional open prostatectomy in many institutions due to reduced blood loss, nerve sparing, less…
- Trial name
- NCT01744262
- Testing
- Total intravenous anesthesia, Inhalation Anesthesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Obstructive Sleep Apnea, Breathing, Sleep-Disordered
Cheeks Appearance as a Novel Predictor of Obstructive Sleep Apnea The CASA Score Study
Cheeks appearance is a screening tool developed based on cheeks observation to identify volume, flaccidity or both to predict people with probable obstructive sleep apnea.
- Conditions
- Obstructive Sleep Apnea, Breathing, Sleep-Disordered, Muscle Weakness, Muscle Disorder
- Trial name
- CASA (NCT04980586)
- Testing
- CASA score protocol to Non-obstructive sleep apnea Group, CASA score protocol to Mild obstructive sleep apnea Group, CASA score protocol to Moderate obstructive sleep apnea Group
- Where
- Brazil
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Multiple Sclerosis (MS)
Avonex®: Safety, Blood Levels and Effects
The primary objective was to determine the tolerability of a new inhaled formulation of interferon beta-1a when given as a single dose, when given once per week for 4 weeks, and compared with standard intramuscular (IM) AVONEX®…
- Trial name
- C-851 (NCT01863069)
- Testing
- Interferon beta 1a, (IM) AVONEX®
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Trio Medicines Ltd.
Test Anxiety, Diaphragmatic Breathing
Diaphragmatic Breathing Exercises on Stress and Exam Anxiety in High School Seniors: A Randomized Study
This study aims to evaluate the effect of diaphragmatic breathing exercises on stress and exam anxiety in final-year high school students during the exam period.
- Conditions
- Test Anxiety, Diaphragmatic Breathing, Stress Measurement, Psychological
- Trial name
- NCT06949202
- Testing
- breating exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Igdir University
Airway Complication of Anaesthesia, Healthy
The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
The investigators hypothesize that propofol, when compared to sevoflurane, causes the upper airway to collapse more easily and causes less activity in the tongue muscle.
- Trial name
- NCT01557920
- Testing
- Propofol, Sevoflurane
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
Cortical Pharyngeal Area: Excitability, Facilitation and Plasticity in Healthy Subjects
The aims of this study are in four experimental sessions. The aims are: to characterize the excitability of the cortical pharyngeal area with pharyngeal pressure and electromyograms (EMGs), at rest, in awake healthy subjects; to…
- Trial name
- NCT00213382
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Stress, Psychological, Stress, Physiological
Effects of Relaxing Breathing Combined With Biofeedback on the Performance and Stress of Residents During HFS
The harmful effects of stress on health professionals are expressed both in terms of their health (physical or mental) and the quality of work (reduced memory capacity, deterioration in patient care).
- Conditions
- Stress, Psychological, Stress, Physiological, Performance Anxiety, Critical Incident
- Trial name
- RETROSIMU (NCT04141124)
- Testing
- breathing exercise/HRV-biofeedback, Relaxing Breathing, Control
- Where
- France
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
Healthy
Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler
This is an open-Label, Randomized Study in Healthy Normal Volunteers looking at exposure and effects (PK/PD) of multiple doses of Technosphere® Insulin (TI) using the Gen2C inhaler.
- Trial name
- NCT01490762
- Testing
- Technosphere Insulin Inhalation Powder using the Gen2C inhaler, Regular Human Insulin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation
Bioequivalence Study in Healthy Subjects
Pharmacokinetics and Bioequivalence Study of Budesonide Inhalation Aerosol in Humans
The test formulation of Budesonide Inhalation Aerosol is bioequivalent to the reference formulation in healthy Chinese subjects under fasting conditions.
- Trial name
- NCT06924190
- Testing
- Budiair® 200ug/puff inhalation aerosol, budesonide 200ug/puff inhalation aerosol
- Where
- 2 sites in China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Lunan Better Pharmaceutical Co., LTD.
Problem Drinking
Changing Impulsivity With Mindful Breathing Therapy to Reduce Problem Drinking
The investigators plan to establish the efficacy of a novel breathing-based mindfulness training (BBMT, a much simplified, easy-to-use version of standard MM) for problem drinking, and test whether impulsivity mediates this…
- Trial name
- BBMT (NCT02527720)
- Testing
- Mindfulness Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Lung Disease
Ozone Exposure and Dose Delivered to Human Lungs
Ozone is an air pollutant formed in at ground level by the chemical reaction between oxygen and automobile emissions in the presence of sunlight.
- Trial name
- NCT00013780
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Healthy, Healthy Adult
Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level and re-ascent from sea level to 2850m on heart rate variability and other hemodynamic parameters in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801846
- Testing
- Descent and re-ascent (2850m, sea level)
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
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