Clinical trials: Inhalation
Nebulizers and Vaporizers
Explorative Clinical Investigation to Investigate the Ability of PreciseInhale to Direct Regional Lung Targeting and Reduce the Degree of Throat Deposition and Subsequent Gastrointestinal Absorption in Healthy Volunteers After Inhalation of Test Drug Substances Via the PreciseInhale System
This is a single site, open label, 4-inhalation sessions, explorative clinical investigation to investigate the ability of PreciseInhale to direct regional lung targeting and reduce the degree of throat deposition and subsequent…
- Trial name
- NCT04946630
- Testing
- PreciseInhale, Seretide Evohaler forte
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Inhalation Sciences Sweden AB
Stress, Stress, Psychological
Interactive Effects of Mindfulness and Slow-paced Breathing
The purpose of this study is to better understand specific stress-management practices on mood, sleep, and physiology. Participants will be assigned to one of three interventions (they all active interventions - none are a…
- Conditions
- Stress, Stress, Psychological, Stress Physiology, Sleep
- Trial name
- NCT04866901
- Testing
- Slow-Paced Breathing (SPB), Mindfulness (M), Yogic Breathing (SPB+M)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Asthma
An Evaluation of VR942 in Healthy Volunteers and Patients With Mild Asthma
The purpose of the study is to Evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of single inhaled doses of VR942 in healthy subjects (part 1) and repeated doses in mild asthmatics (part 2).
- Trial name
- NCT02473939
- Testing
- VR942 delivered via a Vectura Dry Powder Inhaler
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Vectura Limited
Chronic Obstructive Pulmonary Disease
An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease
This study is investigating the possible mechanisms of action of an inhaled treatment (Seretide), currently used worldwide in millions of patients with COPD (Chronic Obstructive Pulmonary Disease) and how it improves the symptoms…
- Trial name
- IMAS (NCT00974805)
- Testing
- Seretide 500 Accuhaler
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Apnea
A Study of Breathing Sound-based Classification of Patients With Breathing Disorders
Sleep-disordered breathing can damage the cardiovascular system, and may also lead to dysregulation of the autonomic nervous system, endocrine disorders, and hemodynamic changes, causing multi-system and multi-organ damage.
- Trial name
- NCT05868694
- Testing
- polysomnography
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huai'an No.1 People's Hospital
Dementia, Relation, Family
Gentle Gymnastics and Relationship Between Family Caregivers and Residents With Dementia in Nursing Homes
The goal of this multicentre cluster randomised controlled trial is to evaluate the effects of a joint practice of a Tai Chi inspired gymnastics programme in nursing home on the relationship between family caregivers and…
- Trial name
- NCT05686486
- Testing
- Tai Chi inspired gymnastics
- Where
- 4 sites in France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fondation Mederic Alzheimer
Anesthesia, Airway Morbidity
Preoxygenation Using High Flow Oxygen : Efficacy and Tolerance in Healthy Volunteers
High flow nasal cannula oxygen has been proposed to perform preoxygenation in patients with acute respiratory failure requiring orotracheal intubation in intensive care units.
- Conditions
- Anesthesia, Airway Morbidity, Safety Issues
- Trial name
- PreOx-OHD (NCT03399695)
- Testing
- preoxygenation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Asthma
Dysfunctional Breathing in Difficult Asthma.
We plan to use the Life Shirt to record tidal volume, respiratory rate and breathing pattern over a 6 hour period in patients admitted with difficult asthma.
- Trial name
- NCT00716677
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Mechanical Low Back Pain
Effect of Deep Breathing on Balance in Patients With Chronic Mechanical Low Back Pain
The primary purpose of this study is to investigate the effects of deep breathing pattern on dynamic balance in patients with chronic mechanical low back pain versus healthy controls.
- Trial name
- NCT06398249
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October 6 University
Healthy
Pharmacokinetics & Tolerability Study of MAP0004 Co-administered With Ketoconazole
Compare the DHE pharmacokinetic profiles observed following administration of: 1. MAP0004 (oral inhalation DHE) 2. MAP0004 co-administered with oral Ketoconazole 3.
- Trial name
- NCT01468558
- Testing
- MAP0004, IV DHE, Ketoconazole
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Allergan
Healthy Volunteers
AZD8683 Single Ascending Dose Study
The aim of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8683 following single ascending dose administrations in healthy male subjects.
- Trial name
- NCT00979849
- Testing
- AZD8683
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Interstitial Lung Disease, Precapillar Pulmonary Hypertension
Exploration of Metabolome in Patients With Interstitial Lung Disease and Pulmonary Hypertension With or Without Specific Pulmonary Hypertension Treatment
Fibrosing interstitial lung diseases (FILDs) encompass a group of rare diseases characterized by progressive pulmonary fibrosis leading to respiratory failure.
- Trial name
- BREATH-TPT (NCT07254338)
- Testing
- Blood sampling for metabolomic profiling, Urine sampling for metabolomic profiling
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Asthma
Repeat Dose GW685698X With Magnesium Stearate, Excipient Bridging Study, In Healthy Volunteers
GW685698X is a novel glucocorticoid receptor agonist that is being developed as an orally inhaled treatment for asthma. In previous studies inhaled GW685698X was administered as a dry powder containing either lactose alone or…
- Trial name
- NCT00522678
- Testing
- GW685698X
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Burnout, Healthcare Workers, Breathing Exercises
A Study Of Resilience And Mental Well-Being Through Breathing Practice For Clinical Care Professionals
The purpose of this study is to assess the immediate and long-term effects of structured breathing on clinical symptoms related to mental health including anxiety, depression, perceived stress, and sleep quality.
- Trial name
- NCT07218458
- Testing
- Structured Breathing
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Work of Breathing
The Role of Heliox in Respiratory Control
Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing…
- Trial name
- NCT07424014
- Testing
- Heliox inspirate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Indiana University
Stress, Anxiety
Effects of Coherent Breathing Breathwork on Health
The investigators are conducting a randomised-controlled trial comparing coherent breathing at ~5.5 breath cycles per minute-bcpm (with equal inhalation/exhalation durations of ~5.5secs each) to a well-designed placebo (paced…
- Conditions
- Stress, Anxiety, Depressive Symptoms, Wellbeing
- Trial name
- NCT05676658
- Testing
- Coherent breathing
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Sussex
Pregnancy Related, Hypertension in Pregnancy
Deep Breathing Techniques (Pranayama) in Pregnancy
Slow deep breathing actives the vagal nerve and leads to a natural reduction in physiological parameters such as blood pressure, heart rate and digestion. The effects of these techniques have not been assessed in pregnancy.
- Conditions
- Pregnancy Related, Hypertension in Pregnancy, Blood Pressure
- Trial name
- NCT05341921
- Testing
- Alternate Nostril Breathing, Bhramari Breathing, Sheetali Breathing
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Respiratory Aspiration, Pregnancy
Gastric Sonography in the Fasted Term Pregnant Patient for Elective Cesarean Delivery
Food residue in the stomach of patients scheduled to have surgery is considered a major risk factor for pulmonary aspiration of gastric contents.
- Trial name
- NCT01980121
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Inhalation Therapy; Complications
The Effect of Watching Informative Animation on Fear and Anxiety in Children
The aim of this project was to determine the effect of showing informative animations to children on anxiety and fear during inhalation therapy. This project is a randomized controlled trial.
- Trial name
- NCT05861232
- Testing
- Behavioral
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mukader Kaya
Healthy
Meditation and Yogic Breathing-driven Modulation of Neurofluid Coupling and Brain Clearance
This study will examine whether meditation and yogic breathing can alter brain fluid movement and waste clearance in healthy adults.
- Trial name
- SPANDHA (NCT07903688)
- Testing
- Nadi Shuddhi, Shoonya Meditation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
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