Clinical trials: Inhalation
Bronchial Asthma, Airway Disease
FeNO Detection in Asthma Diagnosis: A New Technology Approach
The detection of exhaled nitric oxide (FeNO) represents a non-invasive, safe, and rapid approach for assessing endogenous nitric oxide (NO) levels within the airway.
- Trial name
- NCT06852911
- Testing
- Chemiluminescent FeNO Analyzer, Electrochemical FeNO Analyzer
- Where
- 2 sites in China
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Novlead Inc.
Chronic Low-back Pain
Movement Control Exercises With and Without Specific Breathing Techniques for the Treatment of Chronic Low Back Pain
Chronic low back pain (CLBP) is a leading disability globally. Exercise therapies are one of the most commonly prescribed treatment options for CLBP.
- Trial name
- NCT05268822
- Testing
- Home exercise
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Cannabis
A Study of Inhaled Cannabidiol in Healthy Occasional Cannabis Users
The purposes of this study are 1) to determine if the administration of different low doses of CBD (5 mg, 20 mg, 50 mg and 100 mg) result in detectable subjective pleasant drug effect compared to placebo and 2) to qualitatively…
- Trial name
- NCT05320367
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Dyspnea
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a lung disorder commonly caused by smoking, which makes breathing more difficult.
- Trial name
- iNO (NCT03679312)
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Shortness of Breath, Shortness of Breath/Dyspnea
Training Strategies to Maintain Performance
Statement of the Problem and Justification Cognitive performance under physiologically stressful conditions is critical in high-demand environments such as military operations, diving, and firefighting.
- Conditions
- Shortness of Breath, Shortness of Breath/Dyspnea, Respiratory Distress
- Trial name
- NCT07128511
- Testing
- Multiple Inhalation Breathing Pattern, Tactical Breathing Technique
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Florida
Total Intravenous Anesthesia, Desflurane
TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery
Many factors during laparascopic surgery leads to PONV (postoperative nausea and vomiting), such as C02 insufflations causing peritoneal stretch and irritation and type of anaesthesia given during surgery.
- Conditions
- Total Intravenous Anesthesia, Desflurane, Obesity, Pain, Postoperative
- Trial name
- NCT03727607
- Testing
- Desflurane
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Chronic Obstructive Pulmonary Disease
A Trial to Assess the Bioequivalence of Generic Tiotropium Bromide Inhalation Powder and Reference Product in Healthy Adult Participants Under Fasting Conditions (Pilot)
Primary Objective: To evaluate the pharmacokinetics of Tiotropium Bromide Inhalation Powder (Strength:18 mcg; manufactured by Chia Tai Tianqing Pharmaceutical Group Co.
- Trial name
- NCT06326671
- Testing
- Tiotropium Bromide Inhalation Powder, Spiriva HandiHaler
- Where
- China
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Respiratory Disorders
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of Inhaled GSK1995057
GSK1995057 is a fully human, single domain antibody directed against the TNFR1 receptor. The purpose of this study is to investigate the safety, tolerability and pharmacokinetics of inhaled GSK1995057 in healthy subjects.
- Trial name
- NCT01587807
- Testing
- GSK1995057, bronchoalveolar lavage, LPS
- Where
- 2 sites in United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (Disorder)
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled MBS-COV (SNS812) in Healthy Participants
A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled MBS-COV in Healthy Participants
- Trial name
- NCT05677893
- Testing
- MBS-COV
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Oneness Biotech Co., Ltd.
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Chronic Obstructive Pulmonary Disease, Lung Disease Causing Persistent Narrowing of the Airways
AZD2115 Single Ascending Dose Study
AZD2115 Single Ascending Dose Study
- Trial name
- NCT01283984
- Testing
- AZD2115
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of BEA 2180 BR in Healthy Male Subjects
Main study: To investigate safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of BEA 2180 BR Sub-study; To investigate whether treatment with 36 μg tiotropium bromide is able to protect of methacholine-induced…
- Trial name
- NCT02263976
- Testing
- BEA 2180 BR, Respimat® A 4, Methacholine Chloride
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Respiratory Syncytial Virus (RSV)
A Study to Investigate the Safety and Tolerability of Single and Repeat Doses of PC786
This study investigates the safety, tolerability and pharmacokinetics of single and repeat doses of PC786.
- Trial name
- NCT03236233
- Testing
- PC786 - Single doses, PC786 - Repeat doses
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pulmocide Ltd
Post-Acute Sequelae of COVID-19
Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD)
Diaphragm is the principal muscle of inspiration. Diaphragmatic dysfunction is seen in many conditions including following intubation, lung disease, prolonged ventilation, neuromuscular disease, phrenic nerve injury.
- Trial name
- NCT06330376
- Testing
- Usual care of traditional treatment, Specific DB program/Diaphragmatic manipulation program
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Airway Obstruction, Sedation Complication
Medical Device for Airway Patency During Sedation
OVERALL SYNOPSIS PART A: Systematic evaluation in spontaneously breathing healthy volunteer study participants of cumulative duration of manual measures for airway patency and for mask ventilation with airway device prototype…
- Conditions
- Airway Obstruction, Sedation Complication, Perioperative Complication
- Trial name
- STAIRWAY-2 (NCT06270212)
- Testing
- STAIRWAY, NO DEVICE
- Where
- Sweden
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Stairway Medical AB
Dysfunctional Voiding, Urinary Dysfunction
At-Home Diaphragmatic Interventions for Voiding Abnormalities (DIVA)
The goal of the DIVA trial is to test the effectiveness of at-home diaphragmatic breathing exercises with bladder hygiene education in female patients with symptoms of difficulty urinating (dysfunctional voiding).
- Trial name
- DIVA (NCT06165731)
- Testing
- Diaphragmatic Breathing Exercises, Bladder Hygiene Education
- Where
- 2 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Duke University
Complication, Postoperative, Perioperative/Postoperative Complications
The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
This study aims to study the efficacy of a preoperative "bundle" of interventions, which consists of preoperative physiotherapy, nutritional support and cognitive exercises on elderly frail patients undergoing major abdominal…
- Trial name
- NCT02921932
- Testing
- Ensure, Resource 2.0 and Glucerna, Cognitive Training, Memory Card Game, 'Threshold' Inspiratory Muscle Trainer, Respironics of New Jersey Inc
- Where
- Singapore
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs
Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients.
- Trial name
- NCT02436213
- Testing
- Cardiopulmonary exercise test, Blood test
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Healthy Volunteers
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder (TPIP) in Healthy Participants
The primary purpose of this study is to evaluate the safety and tolerability of single and multiple doses of treprostinil palmitil inhalation powder in healthy participants.
- Trial name
- NCT06091579
- Testing
- Treprostinil Palmitil Inhalation Powder
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Lung Disease
Ozone Exposure and Dose Delivered to Human Lungs
Ozone is an air pollutant formed in at ground level by the chemical reaction between oxygen and automobile emissions in the presence of sunlight.
- Trial name
- NCT00013780
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
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