Clinical trials: Inhalation
Reperfusion Injury, Liver Injury
Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation
This blinded, placebo-controlled study will administer inhaled nitric oxide to patients undergoing liver transplantation. The purpose of the study is to test if inhaled nitric oxide prevents liver injury associated with the…
- Trial name
- NCT00582010
- Testing
- inhaled nitric oxide, nitrogen gas
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Asthma
Evaluating the Efficacy and Safety of Fluticasone Furoate/Vilanterol Trifenatate in the Treatment of Asthma in Adolescent and Adult Subjects of Asian Ancestry.
A randomised, double-blind, placebo-controlled, parallel group multicentre study to evaluate the efficacy and safety of fluticasone furoate/vilanterol trifenatate (FF/VI) inhalation powder delivered once daily for 12 weeks in the…
- Trial name
- NCT01498679
- Testing
- GW685698/GW642444 (fluticasone furoate/vilanterol trifenatate)
- Where
- 28 sites in China, Philippines and 1 more
- Volunteers
- 311 people
- Sponsor
- GlaxoSmithKline
Asthma
Efficacy and Safety Study of Benralizumab Added to Medium-dose Inhaled Corticosteroid Plus LABA in Patients With Uncontrolled Asthma
The purpose of this study is to determine whether Benralizumab reduces the number of asthma exacerbations in patients who remain uncontrolled on medium doses of ICS-LABA.
- Trial name
- NCT01947946
- Testing
- Benralizumab
- Where
- 47 sites in United States, Argentina and 5 more
- Volunteers
- 13 people
- Sponsor
- AstraZeneca
Cystic Fibrosis
Study to Evaluate the Safety and Efficacy of Ciprofloxacin (Inhaled) in Patients With Cystic Fibrosis
To evaluate the change in forced expiratory volume (FEV1) from baseline to Day 28-30 between Cipro Inhale-treated and placebo-treated subjects after a 4-week treatment period.
- Trial name
- NCT00645788
- Testing
- Ciprofloxacin (Cipro Inhale, BAYQ3939)
- Where
- 86 sites in United States, Australia and 7 more
- Volunteers
- 288 people
- Sponsor
- Bayer
Cystic Fibrosis
Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis (CF) Patients With Pseudomonas Aeruginosa (PA)
The purpose of this study was to evaluate the safety and efficacy of multiple courses of AZLI in patients with cystic fibrosis (CF) and lung infection due to Pseudomonas aeruginosa (PA).
- Trial name
- AIR-CF3 (NCT00128492)
- Testing
- AZLI 75 mg two times a day (BID)/ three times a day (TID)
- Where
- 65 sites in United States, Australia and 2 more
- Volunteers
- 274 people
- Sponsor
- Gilead Sciences
Chronic Obstructive Pulmonary Disease
The Study Will Evaluate the Effect of AZD9164 in Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory condition with deteriorating lung function over the years. Patients with COPD experience symptoms of shortness of breath, cough and sputum production.
- Trial name
- LaCrossE (NCT00939211)
- Testing
- AZD9164, Tiotropium
- Where
- 3 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- AstraZeneca
Sleep Apnea, Sleep-Disordered Breathing
Alice PDx User/Validation Extended Trial
The objective of this study is to test the usability of the Alice PDx device by both the end user (patient/participant) and the sleep technician.
- Trial name
- NCT00841906
- Testing
- Alice PDx with only written instructions, Alice PDx with written and verbal instructions
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Philips Respironics
Mycobacterium Infections, Nontuberculous, Cystic Fibrosis (CF)
Trial of Inhaled Molgramostim in Cystic Fibrosis Subjects With Nontuberculous Mycobacterial Infection
A study to evaluate the efficacy of inhaled molgramostim administered open-label to adult cystic fibrosis (CF) subjects with chronic pulmonary nontuberculous mycobacterial (NTM) infection, with or without ongoing…
- Trial name
- ENCORE (NCT03597347)
- Testing
- Molgramostim nebulizer solution, PARI eFlow nebulizer system
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Savara Inc.
SARS (Severe Acute Respiratory Syndrome), Coronavirus
Nitric Oxide Gas Inhalation in Severe Acute Respiratory Syndrome in COVID-19
Severe acute respiratory syndrome (SARS-CoV2) due to novel Coronavirus (2019-nCoV) related infection (COVID-19) is characterized by severe ventilation perfusion mismatch leading to refractory hypoxemia.
- Trial name
- NOSARSCOVID (NCT04306393)
- Testing
- Nitric Oxide Gas
- Where
- 5 sites in United States, Sweden
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Healthy
A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers
Exosomes are naturally occurring nanosized vesicles and comprised of natural lipid bilayers with the abundance of adhesive proteins that readily interact with cellular membranes.
- Trial name
- NCT04313647
- Testing
- 1X level of MSCs-Exo, 2X level of MSCs-Exo, 4X level of MSCs-Exo
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Asthma
Inhaled Corticosteroids After a Pediatric Emergency Visit for Asthma
Specific Aim: To determine whether a prescription for Inhaled Corticosteroids (ICS) added to standard Emergency Department (ED) discharge therapy for young children with persistent asthma symptoms increases ICS use and improves…
- Trial name
- NCT00294398
- Testing
- ICS Prescription + Standard Asthma ED Discharge Therapy, Standard Asthma ED Discharge Therapy
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Children's Hospital of Philadelphia
Pulmonary Arterial Hypertension
Beraprost-314d Added-on to Tyvaso® (BEAT)
This is a multicenter, double-blind, randomized, placebo-controlled Phase 3 study, to assess the efficacy and safety of BPS-314d-MR when added-on to inhaled treprostinil (Tyvaso®)in patients with pulmonary arterial hypertension.
- Trial name
- BEAT (NCT01908699)
- Testing
- Beraprost Sodium 314d Modified Release Tablets
- Where
- 75 sites in United States, Israel
- Volunteers
- 273 people
- Sponsor
- Lung Biotechnology PBC
Sleep Disordered Breathing
Peak(R) vs. Electrocautery in Children Undergoing Tonsillectomy With Adenoidectomy
Given the large numbers of children who undergo tonsillectomy (by the time a child is 15 years old, 13% of his/her peers will have had a tonsillectomy), the significant morbidity, and direct and indirect costs associated with…
- Trial name
- NCT02533999
- Testing
- PEAK® Plasma System, Electrosurgery
- Volunteers
- 75 people
- Sponsor
- Nemours Children's Clinic
Sleep Apnea Syndromes, Oxidative Stress
Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea
Sleep-disordered breathing (SDB) is a condition in which a person experiences frequent breathing pauses during sleep, also known as sleep apnea.
- Conditions
- Sleep Apnea Syndromes, Oxidative Stress, Cardiovascular Diseases
- Trial name
- SASS (NCT00607893)
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Cystic Fibrosis
Safety and Tolerability Trial of Inhaled Alpha1-Proteinase Inhibitor (Human), Hydrophobic Chromatography Process (Alpha-1 HC) in Subjects With Cystic Fibrosis
This was a randomized, double-blind, placebo-controlled, dose escalation study to assess the safety and tolerability of 100 mg and 200 mg of inhaled Alpha-1 HC administered once a day for three weeks in subjects aged 18 years and…
- Trial name
- NCT01684410
- Testing
- Alpha-1 HC 100 mg, Alpha-1 HC 200 mg
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Grifols Therapeutics LLC
COVID-19
Study in Participants With Early Stage Coronavirus Disease 2019 (COVID-19) to Evaluate the Safety, Efficacy, and Pharmacokinetics of Remdesivir Administered by Inhalation
The primary objective of this study is to characterize the impact of inhaled remdesivir (RDV) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in participants with early stage coronavirus disease 2019…
- Trial name
- NCT04539262
- Testing
- Remdesivir (RDV)
- Where
- 28 sites in United States
- Volunteers
- 156 people
- Sponsor
- Gilead Sciences
Smoke Inhalation Patients
European Survey: Risk of Cyanide Poisoning in Smoke Inhalation
Cyanide poisoning is commonly viewed as a rare but dramatic event, occurring in industrial or laboratory settings as the result of accidental releases of hydrogen cyanide (HCN) gas (e.g.
- Trial name
- RISK (NCT01386788)
- Testing
- There is no intervention planned (observational)
- Where
- 2 sites in Germany
- Volunteers
- 102 people
- Sponsor
- Dr. Ernst MW Koch
Pulmonary Disease, Chronic Obstructive
Tiotropium+Olodaterol Fixed Dose Combination (FDC) Versus Tiotropium and Olodaterol in Chronic Obstructive Pulmonary Disease (COPD)
The overall objective of this study is to assess the efficacy and safety of 52 weeks once daily treatment with orally inhaled tiotropium + olodaterol FDC (delivered by the RESPIMAT Inhaler) compared with the individual components…
- Trial name
- NCT01431274
- Testing
- tiotropium + olodaterol, tiotropium, olodaterol
- Where
- 239 sites in United States, Argentina and 23 more
- Volunteers
- 2,624 people
- Sponsor
- Boehringer Ingelheim
Cardiac Arrest
A Survey of Factors Associated With the Successful Recognition of Agonal Breathing and Cardiac Arrest.
The overall goal of this pilot study is to design and conduct a survey of 9-1-1 call takers in the province of Ontario, Canada to better understand the factors associated with the successful identification of cardiac arrest…
- Trial name
- NCT00848588
- Where
- Canada
- Volunteers
- 404 people
- Sponsor
- Ottawa Hospital Research Institute
Airway Reflexes, Protective, Recovery After Neuromuscular Block
Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
Protective airway reflexes may be impaired in the postoperative period, creating the potential for aspiration of gastric contents, even after a patient exhibits appropriate response to command.
- Conditions
- Airway Reflexes, Protective, Recovery After Neuromuscular Block, Anesthetic Recovery
- Trial name
- NCT01199237
- Testing
- Sevoflurane, Desflurane, Rocuronium
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- University of California, San Francisco