Clinical trials: Inhalation
Sickle Cell Disease, Asthma
Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial
Acute and chronic pulmonary complications with concomitant inflammatory response are a leading cause of morbidity and mortality in children with sickle cell disease (SCD).
- Conditions
- Sickle Cell Disease, Asthma, Acute Chest Syndrome
- Trial name
- NCT02187445
- Testing
- Budesonide inhalation suspension
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Vanderbilt University
Peritoneal Metastases
Feasibility of Preoperative Inspiratory Muscle Training for Patients With Peritoneal Metastases
The goal of this randomized controlled feasibility study was to evaluate the feasibility of preoperative inspiratory muscle training in patients undergoing surgery because of peritoneal metastases.
- Trial name
- NCT05665257
- Testing
- Inspiratory muscle training, Mini-PEP
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Pulmonary Disease, Chronic Obstructive
Safety, Tolerability and Pharmacokinetics (PK) Study of GSK2269557 in Healthy Subjects
GSK2269557 is being developed as an anti-inflammatory and anti-infective agent for the treatment of inflammatory airways diseases.
- Trial name
- NCT03189589
- Testing
- GSK2269557 500 µg, GSK2269557 750 µg
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Mechanical Ventilation Complication, Intensive Care Medicine
Maximum Inspiratory Pressure, Grip Strength and Physical Functional Status Relationship in MV Patients
The maximal inspiratory pressure or negative inspiratory force values is a parameter that measures the functional ability of the respiratory system.
- Trial name
- NCT06602050
- Testing
- HG and NIF
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Saglik Bilimleri Universitesi
Breathing Sound, Low Back Pain
Breathing and Core Stability Exercise Effects on Lumbopelvic Pain
Lumbopelvic pain refers to self-reported pain in areas of lower region, anterior and posterior pelvic tilt or combination of these.
- Conditions
- Breathing Sound, Low Back Pain, Post-operative Pain, Pelvic Pain
- Trial name
- NCT05405127
- Testing
- traditional physical therapy, core stability exercises
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive
Effect of Positive Airway Pressure Therapy on Hospitalization and Mortality in SDB Patients With Comorbid Chronic Obstructive Pulmonary Disease (COPD) or/and Heart Failure (HF)
The aim of the study is to test the hypothesis that treatment of sleep disordered breathing (SDB) in patients with comorbid chronic obstructive pulmonary disease (COPD) and/or heart failure (HF) with positive airway pressure…
- Conditions
- Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive, Heart Failure
- Trial name
- NCT02923505
- Testing
- polygraphy or polysomnography
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 383 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Covid19
A Clinical Study Evaluating Inhaled Aviptadil on COVID-19
This study is a multicenter, prospective, placebo-controlled, comparative, randomized, double-blind local phase II clinical trial. Duration of study is 18 months.
- Trial name
- HOPE (NCT04844580)
- Testing
- Inhaled Aviptadil
- Where
- 9 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Centurion Pharma
Congestive Heart Failure
Breathing Relaxation Exercise Heart Failure
The aim of the study is to determine the effect of breathing and relaxation exercises on dyspnea, fatigue and self-care level in heart failure patients.
- Trial name
- NCT05905627
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- University of Yalova
Bronchiectasis
Comparative Effectiveness and Safety of Inhaled Corticosteroids and Antimicrobial Compounds for Non-CF Bronchiectasis
The purpose of this study is to provide patients and their physicians with greater understanding of the risks and benefits of commonly used therapies for treatment of non-CF bronchiectasis
- Trial name
- NCT02714283
- Testing
- inhaled corticosteroid therapy, macrolide therapy
- Volunteers
- 90,089 people
- Sponsor
- Oregon Health and Science University
Asthma
Efficacy and Safety Study of FP MDPI Compared With FS MDPI in Adolescent and Adult Patients With Persistent Asthma
The primary objective of this study was to evaluate the efficacy of fluticasone propionate (Fp) multidose dry powder inhaler (MDPI) and fluticasone propionate/salmeterol xinafoate (FS) MDPI when administered over 12 weeks in…
- Trial name
- NCT02141854
- Testing
- FS MDPI, Fp MDPI, Albuterol/salmeterol HFA MDI
- Where
- 154 sites in United States, Canada and 7 more
- Volunteers
- 882 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Heart Failure
Inspiratory Muscle Training in HFpEF
This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.
- Trial name
- NCT06510231
- Testing
- Inspiratory Muscle Training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mayo Clinic
Social Anxiety Disorder
Breathing Focused Yoga in Social Anxiety Disorder
The goal of this study is to determine the safety and effectiveness of Breathing Focused Yoga (BFY) in improving symptoms of social anxiety disorder (SAD).
- Trial name
- NCT02266680
- Testing
- Yoga Treatment Group
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Extremely Premature Infant, Pain
Creation of a Scale for Assessing Pain and Discomfort in Extremely Premature Infants (EDEX) Hospitalised in Neonatal Intensive Care, Inspired by the Early Infant Pain and Discomfort Scale (EDIN)
The goal of this study is to develop a new scale for assessing prolonged pain, dedicated to extremely premature infants born before 27 weeks of gestation, adapted to their particular ways of expressing pain and discomfort, which…
- Conditions
- Extremely Premature Infant, Pain, Discomfort Symptoms
- Trial name
- DOU-PREMA (NCT07481331)
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Child
Pediatric Diaphragm Thickness Trial
The evaluation of diaphragm function in ventilated patients is not easy. One option is to use esophageal pressure (Pes) measurements but recently, diaphragmatic ultrasound has proven itself as a useful tool in this setting.
- Trial name
- PeDia (NCT04882553)
- Testing
- Diaphragmatic echography, Measurement of esophageal pressure, Registration of respiratory mechanics
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University Hospital, Antwerp
Inhalational Anthrax
A Field Study Evaluating Clinical Benefit and Safety of AIGIV (ANTHRASIL®) in Inhalational Anthrax Patients
This study will evaluate safety and clinical benefit of AIGIV used for treatment of patients with inhalational anthrax. This study will be implemented only in the event of a major anthrax exposure event.
- Trial name
- NCT03569553
- Testing
- AIGIV
- Volunteers
- 100 people
- Sponsor
- Emergent BioSolutions
Ocular Hypertension
Effect of Alternate Therapies on Intraocular Pressure in Ocular Hypertension
The purpose of this study is to evaluate the effect of complementary and alternative therapies, specifically alternate nostril breathing and foot reflexology, on intraocular pressure in patients with ocular hypertension.
- Trial name
- NCT02993445
- Testing
- Alternate Nostril Breathing, Foot Reflexology
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Temple University
End-stage Lung Disease
Perioperative Recovery Outcomes With a Spontaneous Breathing Strategy in Severely Underweight Lung Transplant Recipients
The goal of this prospective, multicenter, single-arm clinical study is to learn whether a spontaneous breathing-preserving perioperative management strategy can improve recovery and is safe in lung transplant recipients with…
- Trial name
- NCT07384572
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 56 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Asthma
A 12-Week Study To Assess The Safety Of Fluticasone Propionate/Salmeterol 100/50 Hydrofluoroalkane (HFA) Versus Fluticasone Propionate 100 HFA In Children With Asthma
This study is to assess the safety of an investigational drug in children 4 to 11 years of age who have asthma. The subjects will attend 7 clinic visits, of which up to 3 will be in the morning, and have lung function tests…
- Trial name
- NCT00441441
- Testing
- fluticasone propionate, fluticasone propionate/salmeterol
- Where
- 55 sites in United States, Australia and 11 more
- Volunteers
- 351 people
- Sponsor
- GlaxoSmithKline
Out-Of-Hospital Cardiac Arrest, Advanced Cardiac Life Support
Cardiac Arrest and Ventilation Method
Comparison of Manual Ventilation and Automatic Mechanical Ventilation during CPR, Pilot \& Feasibility Study (CAVE-I trial)
- Conditions
- Out-Of-Hospital Cardiac Arrest, Advanced Cardiac Life Support, Ventilation
- Trial name
- NCT05550454
- Testing
- Automatic Mechanical Ventilation, Manual Ventilation
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Mechanical Ventilation, Positive End-Expiratory Pressure
Influence of Inspiratory Pause on Ventilatory Efficiency in Robotic Surgery. A Prospective Paired Study.
The investigators aim to determine if the modification of the end inspiratory pause (EIP) during mechanical ventilation adds benefit when applied to patients undergoing robotic surgery and who are ventilated under an…
- Conditions
- Mechanical Ventilation, Positive End-Expiratory Pressure, Anesthesia
- Trial name
- NCT05514366
- Testing
- Modifying EIP under a tOLA before pneumoperitoneum, Modifying EIP under a tOLA with pneumoperitoneum, Atelectasis test
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
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