Clinical trials: Inhalation
Cystic Fibrosis
Amiloride Solution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa in Patients With Cystic Fibrosis
The purpose of this research study is to determine if multiple doses of two inhaled drugs will help Cystic Fibrosis patients whose lungs are infected with a bacteria called Burkholderia dolosa.
- Trial name
- NCT00547053
- Testing
- Amiloride Solution for Inhalation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Boston Children's Hospital
Surgery, Oncology
Assessment of Cardiac Coherence Associated With Medical Hypnosis on Preoperative Anxiety in Oncological Surgery
The investigator proposes to use the cardiac coherence technique (Cardiac Coherence) coupled with a hypnosis session to reduce pre-operative anxiety.
- Trial name
- COHEC2 (NCT05197972)
- Testing
- cardiac coherence program coupled with hypnosis
- Where
- 4 sites in France
- Volunteers
- 296 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- SAVE (NCT00005777)
- Testing
- Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 220 people
- Sponsor
- NICHD Neonatal Research Network
Gastrointestinal Disease, Esophageal Cancer
PMRR-NO: Pulmonary Metabolic Radiation Response Versus Exhaled Nitric Oxide
The goal of this clinical research study is to use a new breathing test that measures the amount of nitric oxide (NO) you exhale.
- Conditions
- Gastrointestinal Disease, Esophageal Cancer, Lung Cancer
- Trial name
- NCT00867477
- Testing
- Breathing Test, Respiratory Symptoms Questionnaire, Pet Scan
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy
AZD2115 Multiple Ascending Dose Study
This study will investigate the safety and tolerability of AZD2115 following administration of multiple ascending doses.
- Trial name
- NCT01445782
- Testing
- AZD2115
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Mechanical Ventilation
Effects of Inspiration Rise Time on Work of Breathing and Comfort of Conscious Patients on Mechanical Ventilation
Introduction Pressure Support Ventilation is widely used in patients in the ICU. Matching the patient's respiratory needs with adequate ventilator settings is necessary to ensure a low work of breathing (WOB) and maximal patient…
- Trial name
- NCT00294879
- Testing
- pressure support ventilation at 0, 5, and 10% IRT
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Healthy Volunteers
Inspiratory Muscle Endurance of Adults
The aim of this study is to determine the reference value ranges for healthy adults of the incremental threshold load test, which evaluates respiratory muscle endurance.
- Trial name
- NCT05237427
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Urinary Incontinence
360 Degree Expanded Diaphragm Breathing Pattern Training in Individuals With Urinary Incontinence
The aim of this study is to investigate the effect of transferring the healthy intra-abdominal pressure created by 360 degree expanded diaphragm breathing taught to the patient to the pelvic cavity on incontinence problems.
- Trial name
- NCT06003894
- Testing
- kegel exercises, 360 degree expanded diaphragmatic breathing training
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Uskudar University
Tracheostomy
Speaking Valve Influence on Breathing, Swallowing and Vocal Functions in Patients With Tracheostomy.
Speaking valve seems to have a beneficial influence on breathing and secretion management in certain patients with tracheostomy.
- Trial name
- NCT05482022
- Testing
- Shiley™ phonate speaking valve, control
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Loewenstein Hospital
Dental Anxiety
Comparative Clinical Study Between Virtual Reality Hypnosis and Nitrous Oxide Inhalation for Dental Anxie
The vicious circle of dental anxiety impacts major aspects of a child's quality of life. Hypnosis using distraction is one of the most common non-pharmalogical techniques in behavior and pain management in pediatric dentistry.
- Trial name
- HYPNOSEDENT (NCT05167331)
- Testing
- Nitrous Oxide inhalation, Dispositif de RV - HYPNO VR
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
No Specific Medical Conditions or Disease States, No Specific Conditions
Validating Dozee for Contactless Monitoring of Heart, Breathing, and Movemen
The Dozee VS system (K221555) is a contactless device that tracks heart rate and breathing rate using a sensor sheet placed under the mattress.
- Trial name
- NCT07223931
- Testing
- Device: Telemetry monitoring
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Turtle Shell Technologies Pvt. Ltd.
Respiratory Insufficiency, Respiratory Distress Syndrome, Adult
Continuous Positive Airway Pressure (CPAP) Ventilation Using a Novel Full-Face Mask Versus Conventional Helmet
The aim of this study is to compare two methods of delivery of noninvasive mechanical ventilation (NIV). Since patient compliance and mechanical characteristics of the delivery devices are two fundamental variables in the success…
- Conditions
- Respiratory Insufficiency, Respiratory Distress Syndrome, Adult, Chronic Obstructive Pulmonary Disease, Pulmonary Edema
- Trial name
- NCT00944437
- Testing
- Helmet, Full-face mask
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- University of Parma
COPD, COPD-like
Breathing Performance of Healthy Young Adult
The study will recruit subject of healthy adult, COPD-like patient and patient with COPD to investigate the difference of respiratory performance.
- Trial name
- NCT04857541
- Where
- Taiwan
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Hypothermia, Rewarming
Heated Humidified Breathing Circuit Rewarming in Hypothermic Post Cardiopulmonary Bypass Patients.
Hypothermia on admission to the intensive care unit (ICU) following cardiopulmonary bypass (CPB) is common. The investigators propose that rewarming hypothermic (≤ 35 C) patients admitted to the intensive care unit following…
- Trial name
- NCT03697122
- Testing
- Heated Humidified Breathing Circuit and Forced Air Blanket
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Respiratory Disease, Muscle Weakness
Respiratory Muscle Training in Acquired Brain Injury Patients.
Background: Respiratory health problems are one of the main causes of morbidity and mortality in adult people with acquired brain injury (ABI).
- Conditions
- Respiratory Disease, Muscle Weakness, Acquired Brain Injury, Older People--Abuse of
- Trial name
- NCT06070831
- Testing
- Inspiratory muscle training, Expiratory muscle training
- Volunteers
- 26 people
- Sponsor
- University of Salamanca
Pulmonary Arterial Hypertension, Pulmonary Hypertension
Inhaled Nitric Oxide/INOpulse DS for Pulmonary Arterial Hypertension (PAH)
This is a Phase 2, Placebo Controlled, Double-Blind, Randomized, Clinical Study to Determine Safety, Tolerability and Efficacy of Pulsed, Inhaled Nitric Oxide (iNO) Versus Placebo as Add-on Therapy in Symptomatic Subjects with…
- Trial name
- PAH (NCT01457781)
- Testing
- Inhaled Nitric Oxide 0.025 mg/kg IBW/hr delivered via INOpulse DS Device, Inhaled nitric oxide 0.075 mg/kg IBW/hr delivered via INOpulse DS Device
- Where
- 51 sites in United States, Canada
- Volunteers
- 80 people
- Sponsor
- Bellerophon Pulse Technologies
Asthma
The Use of the Propeller Health Platform to Improve Inhaled Corticosteroid (ICS) Use Among Adults With Uncontrolled Persistent Asthma
This is a behavioral randomized controlled trial of adults with uncontrolled persistent asthma that tests if the Propeller Health sensor, mobile application, and dashboard can improve adherence to ICS.
- Trial name
- NCT03860519
- Testing
- Electronic Medication Monitors on ICS and SABA - Active Mode, Electronic Medication Monitors on ICS and SABA - Silent Mode, Asthma App Tracking of ICS/SABA Usage - Active Mode
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Hyperventilation
Physiotherapy and Dysfunctional Breathing
Traditionally, the physiotherapy management of people with dysfunctional breathing or hyperventilation syndrome is breathing re-training.
- Trial name
- HVS (NCT00895219)
- Testing
- Breathing re-training, Breathing re-training and musculoskeletal techniques
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Diabetes Mellitus, Type 1
Safety and Efficacy of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes Mellitus.
This is a research study of a study drug known as LY041001 or human insulin inhalation powder (HIIP). HIIP is a powder form of insulin made to be inhaled through the mouth and into the lungs using a special handheld device.
- Trial name
- NCT00063128
- Testing
- insulin, human insulin inhalation powder (HIIP)
- Where
- 25 sites in United States
- Volunteers
- 119 people
- Sponsor
- Eli Lilly and Company
Sleep-Disordered Breathing, Heart Failure
Validation of the ApneaScan Algorithm in Sleep Disordered Breathing
Sleep disordered breathing, in which patients my breath deeply, shallowly or stop breathing for periods whilst asleep, is common in heart failure and associated with a poor prognosis.
- Trial name
- ApneaScan (NCT02204865)
- Testing
- Pacemaker/ICD
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
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