Clinical trials: Inhalation
Chronic Obstructive Pulmonary Disease
Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NAVA used the electrical activity of the diaphragm (EAdi) to initiate and deliver in proportion of an inspiratory assistance. During inspiration, EAdi signal occurred earlier than airflow or pressure variations in the airway.
- Trial name
- NAVASYNC (NCT01042080)
- Testing
- NAVA, Expiratory trigger (ET)
- Where
- 2 sites in France
- Volunteers
- 16 people
- Sponsor
- Hôpital Européen Marseille
Transplantation, Pain Management
Effect of Breathing Exercise on Pain and Quality of Recovery in After Transplantation Patients: A Randomized Controlled Trial
The researchers will fill out the "Patient Introduction Form" for the patients who agreed to participate in the study after obtaining permission from the experimental group with the "Informed Consent Form" the day before the…
- Conditions
- Transplantation, Pain Management, Quality of Recovery 40
- Trial name
- NCT07067580
- Testing
- respiratory exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
Bronchiolitis Acute
Evaluation of Two Doses of Nitric Oxide (NO) Given Intermittently Via Inhalation to Subjects With Bronchiolitis
Prospective, Double-Blinded, Randomized, Multi-Center Study for Evaluation of Two Doses of Nitric Oxide (NO) Given Intermittently Via Inhalation to Subjects With Bronchiolitis The proposed study judiciously expands these…
- Trial name
- NCT04060979
- Testing
- Nitric Oxide, Standard Supportive treatment
- Where
- 7 sites in Israel
- Volunteers
- 95 people
- Sponsor
- Beyond Air Inc.
Stridor
Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children
The study aims to analyze and compare the clinical effects of using inhaled budesonide or intravenous dexamethasone in the treatment of postextubation stridor on children admitted to the pediatric intensive care units at Hospital…
- Trial name
- BUDEXA (NCT02056379)
- Testing
- Budesonide, Dexamethasone
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Hospital Israelita Albert Einstein
Pulmonary Disease, Chronic Obstructive
Efficacy, Pharmacokinetics and Safety Comparison of Salmeterol Inhalation Powder Administered Via the HandiHaler® 2 and Serevent® Diskus® in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this trial was to establish non-inferiority of lung function response to 25 μg salmeterol, administered as the xinafoate salt, in an inhalation powder delivered from hard polyethylene (PE) capsules via…
- Trial name
- NCT02242227
- Testing
- Salmeterol xinafoate, Serevent® Diskus®
- Volunteers
- 111 people
- Sponsor
- Boehringer Ingelheim
Sleep Apnea, Obstructive, Sleep Apnea Syndromes
Continuous Positive Airway Pressure (CPAP) After Adenotonsillectomy in Children
Obstructive sleep-disordered breathing (SDB) affects 2-3% of children and may lead to problems with nighttime sleep and daytime behavior, learning, sleepiness, and mood.
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Child Behavior Disorders, Attention Deficit Disorder With Hyperactivity
- Trial name
- NCT01554527
- Testing
- CPAP treatment, No CPAP treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Michigan
Chronic Obstructive Pulmonary Disease, COPD
Evaluation of Efficacy and Safety of Symbicort® as an add-on Treatment to Spiriva® in Patients With Severe COPD.
The purpose of this study is to investigate the effect of combined treatment with Symbicort and Spiriva, in terms of improvement of lung function, symptoms and inflammatory markers, in patients with severe COPD.
- Trial name
- NCT00496470
- Testing
- Symbicort (budesonide/formoterol turbuhaler 320/9ug), Spiriva (tiotropium bromide 18ug)
- Where
- 93 sites in Australia, Canada and 7 more
- Volunteers
- 660 people
- Sponsor
- AstraZeneca
Asthma
Asthma Control-A "Patient Follow up Programme" Maintenance and Reliever Therapy in a Single Inhaler
To investigate the change in patient's asthma symptom control using ACQ scores after 4 to 6 weeks of Symbicort Turbuhaler (budesonide/ formoterol) in SMART approach.
- Trial name
- NCT00524641
- Where
- 2 sites in Vietnam
- Volunteers
- 1,254 people
- Sponsor
- AstraZeneca
Healthy Aging
What Makes People Better at Retrieving Difficult Words?
This study is being conducted to learn more about how various personal and situational characteristics are related to the ability to produce words in response to definitions.
- Trial name
- NCT05066750
- Testing
- Mindful breathing, Control video
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Colorado Springs
Pediatric Respiratory Diseases, Ventilator Weaning
WOB and Paediatric Mechanical Ventilation
Rationale: The most common approach to weaning infants and children is gradual reduction of ventilatory support ("traditional approach").
- Conditions
- Pediatric Respiratory Diseases, Ventilator Weaning, Respiration, Artificial, Respiratory Failure
- Trial name
- PedWOB (NCT05254691)
- Testing
- Sprinting
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
Study to Evaluate Safety and Efficacy of Inhaled Bimosiamose for the Treatment of Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to determine whether inhalation of Bimosiamose is safe and effective in the treatment of patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT01108913
- Testing
- Bimosiamose
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Revotar Biopharmaceuticals AG
Pulmonary Disease
A Single-center Study to Assess Peak Inspiratory Flow (PIF) in Different Stages' COPD Patients by Using the In-check Method.
Peak Inspiratory Flow Rate (PIFR) is defined by the fastest flow rate noted during the inspiratory cycle. Inhaled medication plays an important role in the treatment of chronic obstructive pulmonary disease (COPD), with dry…
- Trial name
- INSPIRE (NCT01855659)
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
COVID-19, Stress
Yogic Breathing and Guided Meditation for Long Covid Symptoms
This study aims to assess the impact of brief digitally delivered breathing practice and guided meditation on post-Covid physical and mental symptoms in Long Covid Patients.
- Conditions
- COVID-19, Stress, Shortness of Breath
- Trial name
- NCT05139979
- Testing
- Breathing and Wellness Webinar, Routine Daily Activity
- Where
- United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Pulmonary Disease, Chronic Obstructive
Study To Evaluate Safety And Tolerability Of GSK256066 In Chronic Obstructive Pulmonary Disease (COPD) Patients
This study will evaluate the safety and tolerability of the cfor the first time in mild to moderate COPD patients.
- Trial name
- NCT00549679
- Testing
- GSK256066
- Where
- 15 sites in Estonia, Finland and 4 more
- Volunteers
- 104 people
- Sponsor
- GlaxoSmithKline
Asthma
Salmeterol Xinafoate and Fluticasone Propinate Powder for Inhalation for Asthma
assess the efficacy and safety of Salmeterol Xinafoate and Fluticasone Propinate Powder for inhalation (50ug/250ug) in combination with seretide to patients with Asthma.
- Trial name
- NCT03461627
- Testing
- Salmeterol Xinafoate and Fluticasone Propinate Powder, Seretide
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Anxiety, Psychological Flexibility
Comparative Effects of Four Brief Breathwork and Mindfulness Interventions on Anxiety and Psychological Flexibility: A 4-Arm RCT
This four-arm, single-blind randomized controlled trial examines the effects of four brief daily 5-minute practices over 28 days on psychological flexibility and physiological variables in Spanish-speaking adults.
- Conditions
- Anxiety, Psychological Flexibility, Stress
- Trial name
- BREATH-4 (NCT07621042)
- Testing
- Box Breathing, Cyclic Sighing, Mindfulness AH Exhalation
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Valencian International University (VIU)
Asthma
Inhaled Corticosteroids on Airway Smooth Muscle in Asthma
The main objective is to evaluate how treatment with inhaled corticosteroids (ICS) affects the characteristics of airway smooth muscle (ASM) cells from asthmatic subjects.
- Trial name
- NCT00661973
- Testing
- budesonide
- Where
- United Kingdom
- Sponsor
- Imperial College London
Lung Disease
Safety and Efficacy Study of Nitric Oxide for Inhalation on Chronic Lung Disease in Premature Babies
The purpose of this study is to assess the safety and efficacy of inhaled nitric oxide to reduce the risk of chronic lung disease in pre-term infants with respiratory distress, and to assess the long-term effects of the therapy…
- Trial name
- NCT00551642
- Testing
- Nitric oxide
- Where
- 35 sites in Belgium, Finland and 7 more
- Volunteers
- 800 people
- Sponsor
- Mallinckrodt
Post Mastectomy Lymphedema
Effect of Resisted Deep Breathing and Myofascial Release in Postmastectomy
This study aims to determine the combined effect of resisted deep breathing and Myofascial release on pain, respiratory efficiency, chest mobility and lymph edema in Postmastectomy.
- Trial name
- NCT07576270
- Testing
- Resisted Deep Breathing, Myofascial release
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Gastroesophageal Reflux, Dysphagia
Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry
The goal of this study is to determine which position, maneuvers or combination thereof generates the highest pressure at the EGJ as assessed by high-resolution esophageal manometry and thus greater or more robust contraction of…
- Conditions
- Gastroesophageal Reflux, Dysphagia, Esophageal Motility Disorders
- Trial name
- NCT06329583
- Testing
- diaphragmatic breathing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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