Clinical trials: Inhalation Pneumonia
Respiration, Artificial, COVID-19
Healthcare-associated Infections in Severe COVID-19 During 2020
In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2.
- Conditions
- Respiration, Artificial, COVID-19, Health Care Associated Infection
- Trial name
- COVIACS (NCT04819165)
- Testing
- COVID-19
- Where
- Argentina
- Volunteers
- 252 people
- Sponsor
- Sanatorio Anchorena San Martin
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Respiratory Failure, Respiratory Infection
Avoiding Neuromuscular Blockers to Reduce Complications
The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.
- Conditions
- Respiratory Failure, Respiratory Infection, Aspiration Pneumonia, Pneumonitis
- Trial name
- NCT03962725
- Testing
- Neuromuscular Blocking Agents, Anesthetic Adjuncts
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center
Post-Acute COVID-19 Syndrome
Effect of Inhaled Hydroxy Gas on Long COVID Symptoms
The goal of this clinical trial is to see if several weeks of self-administered, home-based, treatment involving breathing hydroxy gas (a mixture of hydrogen and oxygen) for at least 2 hours a day for 3 weeks, will relieve…
- Trial name
- LCHydroxy (NCT06159296)
- Testing
- Hydroxy gas
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Oxford Brookes University
Pneumonia, Ventilator-associated, Gram-Negative Pneumonia
Nebulized Colistin for Gram Negative VAP Prevention.
Colistin is used as an elective treatment of infections of multi drug resistant gram negative bacteria. Until now colistin is used in the therapeutic regimen of these infections intravenous or nebulized.
- Trial name
- VAPICO (NCT04208945)
- Testing
- Colistin
- Where
- 3 sites in Greece
- Volunteers
- 152 people
- Sponsor
- University of Thessaly
Acute Respiratory Failure (ARF), Nitric Oxide
Modified Inhaled Nitric Oxide in Ventilated Patients With Acute Respiratory Failure
Pneumonia is the main cause of ICU admission in patients with acute respiratory failure (ARF). Severe pneumonia is a serious lung infection caused by bacteria, fungi, viruses, and other pathogens.
- Conditions
- Acute Respiratory Failure (ARF), Nitric Oxide, Pneumonia
- Trial name
- NCT07892001
- Testing
- Modified iNO
- Where
- China
- Volunteers
- 424 people
- Sponsor
- Southeast University, China
Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
To assess the efficacy of administrating daily caspofungin aerosols versus placebo for seven days, in adjunction of conventional systemic antifungal therapy during curative treatment of Pneumocystis pneumonia, on the clinical…
- Conditions
- Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- CaspoNEB (NCT06892951)
- Testing
- Caspofungin Acetate 50 MG, Physiologic saline
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Covid19, Exercise
Inspiratory Muscle Training in COVID-19 Patients
This study aims to investigate whether adjunctive inspiratory muscle training (IMT) can enhance the benefits of pulmonary rehabilitation (PR) in patients with COVID-19.
- Trial name
- ADDIMTCOVID (NCT04595097)
- Testing
- inspiratory muscle traiing
- Where
- Brazil
- Volunteers
- 138 people
- Sponsor
- Escola Superior de Ciencias da Saude
Aspiration Pneumonia
Nocturnal Nasal Continuous Positive Airway Pressure in Aspiration Pneumonia
Numerous elderly patients are suffering from aspiration pneumonia due to anatomical or functional predisposing factors including enteral tube feeding, swallowing difficulties, and gastroesophageal reflux disease (GERD).
- Trial name
- NAP (NCT03844568)
- Testing
- nocturnal nasal continuous positive airway pressure
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Dysphagia After Stroke, Aspiration Pneumonias
Tongue Brush (Orabrush) for Reducing Aspiration Pneumonia in Stroke Patients
The investigators conduct a controlled prospective experimental intervention study to examine whether the use of a tongue brush (Orabrush) can improve the rate of aspiration pneumonia and dysphagia in patients with ischemic…
- Conditions
- Dysphagia After Stroke, Aspiration Pneumonias, Ischemic Stroke
- Trial name
- StrOra (NCT06765018)
- Testing
- Tongue Brush (Orabrush)
- Where
- Germany
- Volunteers
- 252 people
- Sponsor
- University Hospital Marburg
COVID-19
The Use PUL-042 to Reduce the Infection Rate and Progression to COVID-19 in Adults Exposed to SARS-CoV-2
Subjects who have documented exposure to SARS-CoV-2 (COVID-19) will receive 4 doses of PUL-042 Inhalation Solution or 4 doses of a placebo solution by inhalation over 10 days.
- Trial name
- NCT04313023
- Testing
- PUL-042 Inhalation Solution
- Where
- 15 sites in United States
- Volunteers
- 217 people
- Sponsor
- Pulmotect, Inc.
Viral Pneumonia
Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection
The goal of this Phase 2 study is to assess the safety, antiviral biomarker responses and efficacy of SNG001 when given to patients requiring invasive mechanical ventilation due to a respiratory virus infection.
- Trial name
- INVENT (NCT06999603)
- Testing
- SNG001
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 11 people
- Sponsor
- Synairgen Research Ltd.
COVID-19
Study to Evaluate the inHaled Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) On the Protective-Efficacy in Adults (SeiHOPE)
This phase III clinical trial is an endpoint-driven randomized, double-blind, parallel-controlled, multicenter clinical trial, and around 13,000 subjects aged 18 years and above who have previously received 1 dose of…
- Trial name
- NCT05124561
- Testing
- Recombinant COVID-19 vaccine (adenovirus type 5 vector) for Inhalation (Ad5-nCoV-IH)
- Volunteers
- healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Bacterial Infection
Bacterial Pulmonary Infection in PICU
The purpose of this study is to develop a scoring system to allow doctors to accurately identify children on a mechanical ventilator who have bacterial pneumonia.
- Trial name
- NCT00271531
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ventilator Associated Pneumonia ( VAP)
Role of Inhaled Polymyxin as an Adjunct to Intravenous Therapy in Multidrug Resistant Ventilator-associated Pneumonia in Stroke Patients
This study investigates whether adjunctive inhaled colistin enhances clinical recovery and microbiological clearance in multidrug resistant ventilator-associated pneumonia in stroke patients
- Trial name
- NCT07865871
- Testing
- Inhaled colistin, Saline
- Volunteers
- 78 people
- Sponsor
- Ain Shams University
Healthy
Which Apparatus for Inhaled Pentamidine?
The reference nebulizer used for pentamidine nebulization is currently the Respirgard II ®, disposable pneumatic nebulizer. Other nebulizers are on the market and appear to have comparable properties and better availability to…
- Trial name
- NCT02277808
- Testing
- 500mg Amikacine (Amukin®) diluted in 4mL NaCl (0,9%), Respirgard II, Isoneb®
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Parkinson's Disease
Cough According to Stimulus Type in PD
Aspiration pneumonia (APn) occurs at a higher rate in patients with Parkinson's disease (PD) versus healthy adults. This is of particular public health concern given that death secondary to aspiration pneumonia and lung infection…
- Trial name
- NCT02390089
- Testing
- Capsaicin vapor, fog, Videofluoroscopic swallow evaluation
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Florida
Rapid Sequence Induction of General Anesthesia, Sellick Maneuver
Sellick Interest in Rapid Sequence Induction
Lung aspiration can occur when a rapid sequence induction of anesthesia is performed (emergency and/or presence of at least one risk factor for regurgitation of stomach contents).
- Conditions
- Rapid Sequence Induction of General Anesthesia, Sellick Maneuver, Acid Aspiration Syndrome, Lung Aspiration
- Trial name
- IRIS (NCT02080754)
- Testing
- effective sellick maneuver
- Where
- France
- Volunteers
- 3,472 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid-19 Infection
Awake Pronation for Covid-19 Treatment
Observational studies have shown that prone position (PP) in spontaneously breathing patients, may improve oxygenation in individuals with Acute Respiratory Failure (ARF), due to Covid-19 infection.
- Trial name
- NCT04667286
- Testing
- Prone Position (PP)
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COVID-19
Phase I/II Clinical Trial of Recombinant Novel Coronavirus (COVID-19) Vaccine (Adenovirus Type 5 Vector) for Inhalation
This study is a randomized, double-blind, placebo-controlled I/II clinical trial, in order to evaluate the safety and immunogenicity of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) for Inhalation in adults 18…
- Trial name
- NCT04840992
- Testing
- Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) for Inhalation, Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
- Where
- China
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.