Clinical trials: Inhalation Pneumonia
SARS-CoV-2 Infection
SARS-CoV-2-Neutralizing Monoclonal COVID-19 Antibody DZIF-10c by Inhalation
This is the first-in-human phase 1/2a trial of the inhaled administration of the SARS-CoV-2-neutralizing monoclonal antibody DZIF-10c in healthy volunteers and SARS-CoV-2-infected individuals.
- Trial name
- NCT04631705
- Testing
- DZIF-10c
- Where
- 6 sites in Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Cologne
COVID-19
Ozone Plasma on Lung Function and Inflammatory Parameters in Pulmonary Sequelae Associated With Coronavirus 19 Infection
The risk for the development of complications from COVID-19 occurs mainly in patients over 65 years of age, with obesity, arterial hypertension, chronic lung diseases and immunosuppression states.
- Trial name
- NCT05089305
- Testing
- Ozone plasma
- Where
- 2 sites in Mexico
- Volunteers
- 35 people
- Sponsor
- Centro Universitario de Ciencias de la Salud, Mexico
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (SARS-Cov-2) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
- Trial name
- NoCovid (NCT04305457)
- Testing
- Nitric Oxide
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Acute Lung Injury (ALI) Associated With COVID-19, Inflammatory Lung Conditions Associated With COVID-19
First in Human SAD and MAD Study of Inhaled TD-0903, a Potential Treatment for ALI Associated With COVID-19
This is a phase 1 study in healthy subjects to evaluate the safety, tolerability and pharmacokinetics of single (Part A and B) and multiple (Part B) doses of inhaled TD-0903.
- Trial name
- NCT04350736
- Testing
- TD-0903
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Corona Virus Infection, COVID-19
Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (US Trial)
The purpose of this open label, randomized, study is to obtain information on the safety and efficacy of 80 ppm Nitric Oxide given in addition to the standard of care of patients with COVID-19 caused by SARS-CoV-2.
- Conditions
- Corona Virus Infection, COVID-19, SARS-CoV 2, Nitric Oxide
- Trial name
- NCT04397692
- Testing
- Nitric Oxide delivered via LungFit™ system
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Beyond Air Inc.
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (COVID-19) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Dyspnea
- Trial name
- NoCovid (NCT04290858)
- Testing
- Nitric Oxide
- Sponsor
- Xijing Hospital
Interstitial Fibrosis, Pulmonary Disease
Inspiratory Muscle Training in Patients With Interstitial Lung Disease
The aim of this study is to evaluate the effects of inspiratory muscle training program in inspiratory muscle endurance, breathlessness, inspiratory muscle strength, functional capacity and quality of life in patients with…
- Conditions
- Interstitial Fibrosis, Pulmonary Disease, Interstitial Lung Disease, Sarcoidosis
- Trial name
- IMT-ILD (NCT04481074)
- Testing
- Inspiratory muscle training
- Where
- 2 sites in Brazil
- Volunteers
- 14 people
- Sponsor
- Federal University of Minas Gerais
COVID-19
IH Convidecia as Second Booster Dose Against Breakthrough Infections
This will be a randomized single-blind controlled trial to determine the immunogenicity, efficacy and safety of IH Convidecia (CanSino), as a second booster vaccination against Omicron and other emerging VOCs to prevent…
- Trial name
- NCT05517642
- Testing
- Recombinant COVID-19 vaccine (adenovirus type 5 vector) for Inhalation (Ad5-nCoV-IH), mRNA vaccine BNT162b2 (Pfizer)
- Where
- Malaysia
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Ventilator-Associated Pneumonia, Ventilator-Associated Tracheobronchitis
Inhaled Amikacin Versus Placebo in Patients With Ventilator-associated Tracheobronchitis
The primary objective of the AMIVAT trial is to assess whether a 5-day course of inhaled amikacin, compared to placebo, reduces the incidence of progression to ventilator-associated pneumonia (VAP) at day 28 in intensive care…
- Trial name
- AMIVAT (NCT07665788)
- Testing
- Optimized and protocolized nebulization procedure.
- Where
- 17 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Tours
COVID-19, Hypoxemia
iNOPulse for COVID-19
This randomized, controlled trial will assess the efficacy and safety of pulsed iNO in subjects with COVID-19 who are hospitalized and require supplemental oxygen.
- Conditions
- COVID-19, Hypoxemia, Hypoxemic Respiratory Failure
- Trial name
- NO-COVER (NCT04398290)
- Testing
- Inhaled nitric oxide (iNO), Nitrogen gas, Oxygen gas
- Where
- United States
- Sponsor
- Roger Alvarez
Covid19
Effects of Respiratory Muscle Training in Patients With Post COVID-19
The coronavirus disease 2019 (COVID-19) outbreak first appeared in Wuhan, China's Hubei Province in December 2019 and has quickly turned into a worldwide pandemic.
- Trial name
- NCT04972864
- Testing
- Exercise training group, Control training group
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Gazi University
Respiratory Distress Syndrome, Adult
Calfactant for Direct Acute Respiratory Distress Syndrome
This study will determine if administration of an suspension of calfactant, a lung surfactant, intratracheally in patients with Direct Acute Respiratory Distress Syndrome within 48 hours of requiring mechanical ventilation can…
- Trial name
- CARDS (NCT00682500)
- Testing
- Calfactant
- Where
- 32 sites in United States, Australia and 4 more
- Volunteers
- 332 people
- Sponsor
- Pneuma Pharmaceuticals Incorporated
Covid19
Safety, Tolerability and Efficacy of Amorphous Calcium Carbonate (ACC) Compared to Placebo and Best Available Care (BAT), for the Treatment of Moderate to Severe COVID-19 Patients.
This is a phase I/II study with Amorphous Calcium Carbonate (ACC) administered sublingual and in Inhalation concomitantly with BAT (Best Available Care) as Compared to Placebo and BAT for the treatment of Moderate to Severe…
- Trial name
- NCT04900337
- Testing
- AMOR 18 Powder & Inhalation
- Where
- 3 sites in Israel
- Volunteers
- 66 people
- Sponsor
- Amorphical Ltd.
Cataract Extraction, Fasting
Preoperative Fasting for Ambulatory Cataract Surgery: The PRACTICE Study
The current standard for cataract surgery is phacoemulsification with intraocular lens (IOL) implantation. In this procedure, topical anesthesia has become favoured over local anesthetic blocks due to potential serious…
- Conditions
- Cataract Extraction, Fasting, Aspiration Pneumonitis
- Trial name
- PRACTICE (NCT03828500)
- Testing
- Assistant-encouraged fasting up to ASA/CAS guideline limits
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Toronto
Aspiration Pneumonia
Ultrasound Assessment of Gastric Residual Volume in Obese Patients
Gastric emptying is a major risk factor for aspiration of gastric contents.Aspiration into the lungs represents a fatal complication that can occur during anesthesia.
- Trial name
- NCT04544371
- Testing
- gastric ultrasound, nasogastric tube insertion
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Covid19, Obstructive Sleep Apnea
Early Application of Continuous Positive Airway Pressure in Coronavirus Patients at Risk of Obstructive Sleep Apnea
This was an experimental clinical trial, Aim: To evaluate the role of early use of Continuous Positive Airway Pressure (CPAP) in management of moderate to severe Coronavirus disease 2019 patients at risk of Obstructive Sleep…
- Conditions
- Covid19, Obstructive Sleep Apnea, CPAP Ventilation, Corona Virus Infection
- Trial name
- NCT05934916
- Testing
- CPAP ( Continuous positive airway pressure), oxygen therapy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Auscultation, Breathing Sound
Enhancing Respiratory Auscultation Skills Among Medical Students: Digital Stethoscopes in Medical Education
Objectives: This study aims to assess the effectiveness of a novel digital stethoscope curriculum integrated into respiratory auscultation training for medical students.
- Conditions
- Auscultation, Breathing Sound, Asthma, Pneumonia
- Trial name
- NCT06359158
- Testing
- Digital stethoscope use
- Where
- Taiwan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Aspiration Pneumonia, Gastric Volume
Gastric Ultrasound for Preoperative Assessment of Gastric Content in Diabetic Patients
ASA fasting guidelines are only applicable to healthy elective surgery patients. Measuring gastric volume now is not easy, and scintigraphy has remained the gold standard technique for many years.
- Trial name
- NCT04181814
- Testing
- Ultrasound
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
COVID-19
Effect of Selected Types of Breathing Exercises on Different Outcome Measures in Covid-19 Patients
Coronavirus disease 2019 (COVID-19) infection leads to significant respiratory that have negative impact on function and quality of life (QoL). Breathing exercises are effective and important in patients with COVID-19.
- Trial name
- NCT05753293
- Testing
- breathing exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Basma Mosaad Abd-elrahman Abushady
Infectious Pneumonia, Coma
Key to Improve DiagNosis in Aspiration Pneumonia
To evaluate the diagnostic performance of amylase assay performed from bronchial alveolar fluid to differentiate aseptic chemical inhalation pneumonitis from an infectious inhalation pneumonitis in comatose patients with…
- Trial name
- KIDNAP (NCT03182387)
- Where
- France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Bordeaux