Clinical trials: Inhalation Pneumonia
COVID-19
Inhaled Heparin for Hospitalised Patients With Coronavirus Disease 2019 (COVID-19)
Investigator-initiated, multi-centre, randomised, open-label trial of nebulised heparin sodium in addition to standard care compared to standard care alone in hospitalised patients with COVID-19 infection.
- Trial name
- INHALE-HEP (NCT05184101)
- Testing
- Unfractionated Heparin
- Where
- Australia
- Sponsor
- Australian National University
COVID-19
Inhaled Ivermectin and COVID-19
Coronavirus disease-19 is global healthcare crisis. Till May 20, 2020, there were approximately 4,789,205 cases and 318,789 related mortalities were identified globally.
- Trial name
- CCOVID-19 (NCT04681053)
- Testing
- Ivermectin Powder
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mansoura University
COVID-19
Clinical and Electronic Record for Patients With COVID-19 Treated With the Assisted Breathing Helmet - ELMO in Ceará
Continuous positive airway pressure (CPAP) with a helmet-like interface has been described as a safe strategy, with minimal contamination of the environment, improving the oxygenation of patients with acute respiratory failure…
- Trial name
- COVID-19 (NCT05375799)
- Testing
- Clinical Observation
- Where
- Brazil
- Volunteers
- 2,000 people
- Sponsor
- Escola de Saúde Pública do Ceará
Covid19
Effect of Prone Positioning in Patients With COVID-19
COVID-19 is affecting the people around the world and the infected individuals' may either stay asymptomatic or present to hospitals with severe distress and life threatening symptoms.
- Trial name
- NCT04710771
- Testing
- Prone Lying Position, alternate nostril breathing
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Sialkott College of Physical Therapy
Covid19
Ivermectin Nasal Spray for COVID19 Patients
The global escalation of COVID19 pandemic has put the health care system under pressure with urgent need for treatment. In the absence of vaccine and approved drug against SARS-COV2 over the past 6 months, the health authorities…
- Trial name
- NCT04510233
- Testing
- Ivermectin nasal, Ivermectin oral, standard care
- Volunteers
- 60 people
- Sponsor
- Tanta University
Aspiration Pneumonia, Tracheostomy Complication
Intra-laryngeal Implant for Treatment of Chronic Aspirations
This study evaluates the medical device Newbreez LD is designed to protect the lower airways from saliva, liquids and food aspirations in tracheotomized patients suffering from chronic aspirations that require specific care and…
- Trial name
- NCT03325725
- Testing
- NewBreez LD intra-laryngeal implant
- Where
- 2 sites in France
- Sponsor
- ProTiP Medical
COVID-19
Tele-Rehabilitation in Individuals With Covid-19
Coronavirus Disease (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-cov-2). This study was planned as a single-blind randomized controlled pilot study to compare the…
- Trial name
- NCT05305638
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Covid19, Corona Virus Infection
Inhaled Aviptadil for the Treatment of COVID-19 in Patients at High Risk for ARDS
The world is currently experiencing a coronavirus (CoV-2) pandemic. A new (SARS)-CoV infection epidemic began in Wuhan, Hubei, China, in late 2019; originally called 2019- nCoV the virus is now known as SARSCoV- 2 and the disease…
- Conditions
- Covid19, Corona Virus Infection, ARDS, Aviptadil
- Trial name
- NCT04536350
- Testing
- Aviptadil 67μg
- Where
- 2 sites in Switzerland
- Volunteers
- 83 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Critical Illness, Pneumonia
iNO300 Therapy in Critically Ill Patients With Pneumonia
The goal of this clinical trial is to learn the formation and recovery rate of methemoglobin (MetHb) in severely sick patients with pneumonia who receive high doses of inhaled nitric oxide (iNO) therapy at 250 parts per million…
- Trial name
- iNO300 (NCT06950294)
- Testing
- High dose inhaled nitric oxide, standard therapy
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Massachusetts General Hospital
Ventilator-Associated Pneumonia (VAP)
Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial
Previous studies have identified Acinetobacter baumannii (AB), Pseudomonas aeruginosa (PA), and Klebsiella pneumoniae (KP) as the predominant pathogens responsible for ventilator-associated pneumonia (VAP).
- Trial name
- CIVAP (NCT06834971)
- Testing
- Colistimethate sodium (CMS)
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Qilu Hospital of Shandong University
Respiratory Insufficiency
Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.
The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS).
- Trial name
- COVAQ (NCT05392062)
- Testing
- Pathophysiology of gas exchange
- Where
- France
- Volunteers
- 59 people
- Sponsor
- CHU de Reims
Covid19
Inhaled Heparin for Hospitalised COVID-19 Patients
This meta-trial is a prospective collaborative individual participant data meta-analysis of randomised controlled trials and early phase studies.
- Trial name
- INHALE-HEP (NCT04635241)
- Testing
- Unfractionated heparin
- Where
- 5 sites in Argentina, Egypt and 1 more
- Volunteers
- 485 people
- Sponsor
- Australian National University
Acute Respiratory Failure, Covid19
Inspiratory Effort in COVID-19
This study aims at assessing esophageal pressure in patients with acute respiratory failure due to COVID-19 undergoing non invasive respiratory support.
- Trial name
- PERSIA (NCT04666246)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Modena and Reggio Emilia
Stroke, Aspiration Pneumonia
Effect of Oral Hygiene Care on Prevention of Aspiration Pneumonia Among Hospitalized Stroke Patients
Aspiration pneumonia is a common and serious complication among hospitalized patients with stroke. Poor oral hygiene can increase the risk of aspiration pneumonia by promoting bacterial colonization of the oral cavity.
- Trial name
- OH-STROKE (NCT07382089)
- Testing
- Oral hygiene care bundle
- Where
- Ethiopia
- Volunteers
- 90 people
- Sponsor
- Addis Ababa University
Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications
Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications
The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in…
- Conditions
- Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications, Postoperative Respiratory Failure, Postoperative Bronchospasm
- Trial name
- NCT07186933
- Testing
- PEEP titration for Minimum Driving Pressure, Lung Protective Ventilation
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University General Hospital of Patras
Long COVID, Respiratory Disease
Cognitive Muscular Therapy for Patients With Long-COVID and Breathing Pattern Disorder
The aim of the study is to test a treatment known as "Cognitive Muscular Therapy (CMT)" for reducing breathlessness and improving autonomic function in patients with long-COVID.
- Trial name
- COMLOC (NCT06503913)
- Testing
- Cognitive Muscular Therapy, Breathing visualisation
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Salford
Covid19
Use of Inhaled High-molecular Weight Hyaluronan in Patients With Severe COVID19: Feasibility and Outcomes
To determine whether inhaled Yabro protects against progression of COVID19-induced respiratory failure preventing the passage to non-invasive ventilation (NIV) and promotes recovery from COVID19 lung disease in hospitalized…
- Trial name
- HA-COVID (NCT04830020)
- Testing
- HMW-HA
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Campus Bio-Medico University
Pulmonary Disease, Covid19
Effects of Using Mask During the 6-minute Walking Test in Times of COVID-19
Since the beginning of the pandemic caused by SARC-CoV 2, more than 81 million cases have been diagnosed and caused around 1,7 million deaths. Currently, a drug is being sought for the treatment of coronavirus.
- Conditions
- Pulmonary Disease, Covid19, Physical Disability
- Trial name
- NCT04789603
- Testing
- 6-min-walk surgical mask, 6-min-walk Fpp2, 6-min-walk without mask
- Where
- 2 sites in Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Long COVID, Myocardial Injury
Resonance Breathing Training for Long Covid-related Myocardial Injury
An investigation of the efficacy of resonance breathing training in the rehabilitation of patients with Long covid-related myocardial injury
- Trial name
- NCT06379672
- Testing
- Resonance breathing
- Volunteers
- 70 people
- Sponsor
- Chengdu Sport University
Aspiration Pneumonia
Dynamic Laryngotracheal Separation for Aspiration
People who aspirate after neurologic insults such as stroke often develop fatal pneumonia. This study examines the effects of dynamic vocal cord closure on swallowing.
- Trial name
- NCT00580346
- Testing
- Placement of laryngeal implant
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center