Clinical trials: Inhalation of Nitrous Oxide
Nitrous Oxide, Dentistry
Demand-Driven Method for Gas Delivery in a Dental Setting
This study compares two methods of gas delivery in a dental setting: 1) demand-driven (DD) and 2) free-flow (FF). Nitrous oxide and oxygen sedation (NOS) is a common form of minimal sedation for adult and paediatric patients…
- Conditions
- Nitrous Oxide, Dentistry, Drug Delivery System, Comfort
- Trial name
- NCT04305990
- Testing
- Demand-driven delivery method, Free-flow delivery method
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dental Anxiety
Comparative Clinical Study Between Virtual Reality Hypnosis and Nitrous Oxide Inhalation for Dental Anxie
The vicious circle of dental anxiety impacts major aspects of a child's quality of life. Hypnosis using distraction is one of the most common non-pharmalogical techniques in behavior and pain management in pediatric dentistry.
- Trial name
- HYPNOSEDENT (NCT05167331)
- Testing
- Nitrous Oxide inhalation, Dispositif de RV - HYPNO VR
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Non-cephalic Presentation, Inhalation of Nitrous Oxide
Open Randomized Controlled Trial to Evaluate the Efficacy and Safety of Remifentanil Versus Nitrous Oxide in External Cephalic Version at Term in Singleton Pregnancy in Breech Presentation
Objectives: The objective is to demonstrate the superiority of remifentanil versus nitrous oxide as adjuvant analgesic treatment to increase the chances of success of external cephalic version in the management of non-cephalic…
- Conditions
- Non-cephalic Presentation, Inhalation of Nitrous Oxide, Pregnancy Complications, Complications; Cesarean Section
- Trial name
- REMIVER (NCT01735669)
- Testing
- Remifentanil, Nitrous Oxide
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital de Cruces
Exposure to Environmental Pollution, Adverse Effect of Unspecified General Anesthetic
Anesthetic Gas Leakage in Children During Tonsillectomy: a Comparison of Cuffed and Uncuffed Tracheal Tubes
Fires and operating room pollution may occur when anesthesia gases leak into the oropharynx during airway surgery. Investigators sought to measure the concentrations of anesthetic gases that leak into the mouth of children…
- Trial name
- NCT02725164
- Testing
- oxygen concentration, nitrous oxide concentration, carbon dioxide concentration
- Volunteers
- 31 people
- Sponsor
- State University of New York at Buffalo
Anesthesia, Pain
Nitrous Oxide Neuroimaging
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide.
- Conditions
- Anesthesia, Pain, Amnesia
- Trial name
- NONI (NCT06702631)
- Testing
- Nitrous oxide, Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Moderate Sedation, Laceration
Comparison of N2O Inhalation and Ketamine in Pediatric PSA
Ketamine provides effective and relatively safe sedation analgesia for primary closure of lacerated pediatric patients However, deep sedation and adverse effects suggest the opportunity to develop alternative strategies We…
- Trial name
- PSA (NCT00834730)
- Testing
- N2O gas vs ketamine
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Seoul National University Hospital
Contraception, Inhalation of Nitrous Oxide
Nitrous Oxide for Pain Management During In-office Transcervical Sterilization
This is a randomized, double blind study that aims to measure the difference in maximum pain experienced during in-office transcervical sterilization (Essure®) for women receiving either inhaled nitrous oxide or standard oral…
- Trial name
- NEST (NCT02312739)
- Testing
- In-office Transcervical Sterilization (Essure®), Standard Oral pain medications, Intramuscular Ketorolac
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Elective Surgical Procedures, Laparoscopy
Nitrous Oxide Added at the End of Sevoflurane Anesthesia and Recovery
Addition of nitrous oxide N2O towards the end of prolonged isoflurane anesthesia hastens patients recovery. The hypothesis is that the addition of N2O at the end of prolonged sevoflurane anaesthesia also hastens early recovery…
- Conditions
- Elective Surgical Procedures, Laparoscopy, Laparotomy, Anesthesia, General
- Trial name
- SEVONATE (NCT03420586)
- Testing
- Nitrous Oxide
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- General Hospital Zadar
Dental Cares Under Kalinox's Inhalation
Interest of Re-oxygenation After Inhalation of 50% Nitrous Oxide / 50% Oxygen Premix in Dental Cares
The usefulness of re-oxygenation after inhalation of 50% nitrous oxide and 50% oxygen premix (Kalinox 170 bar) during dental care is studied and the pollution resulting from administration of Kalinox is also investigated.
- Trial name
- NCT00643786
- Testing
- Oxygène, Air Médical
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Air Liquide Santé International
Nitrous Oxide Poisoning
Effects of Low Concentrations of Nitrous Oxide
The aim of the study is to test the effects of low concentrations of nitrous oxide on cognitive functions and reaction time in human.
- Trial name
- NCT04050267
- Testing
- Nitrous Oxide
- Where
- Czechia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Nitrous Oxide, Electroencephalography
Effect of Nitrous Oxide on EEG
Our recent preclinical observations suggest that monitoring of slow electroencephalogram (EEG) oscillations may be used to predict the efficacy of rapid-acting antidepressants such as ketamine or nitrous oxide.
- Conditions
- Nitrous Oxide, Electroencephalography, Anesthetic, Inhalation
- Trial name
- HUMANOID (NCT04884893)
- Testing
- Nitrous Oxide
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction
Combination of Nitrous Oxide 70% With Fentanyl Intranasal for Procedural Analgosedation in Children
This study analyzes the analgesic efficacy and adverse events of nitrous oxide 70% combined with basic analgetics compared to nitrous oxide 70% with fentanyl intranasal for analgosedation for short and painful procedures in…
- Conditions
- Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction, Pain
- Trial name
- NCT02533908
- Testing
- Fentanyl intranasal, NaCl 0.9% intranasal
- Where
- Switzerland
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Opioid-Related Disorders, Substance-Related Disorders
Effects of Combined Sevoflurane and Nitrous Oxide Inhalation - 14
The purpose of this study is to determine the effects of combined sevoflurane and nitrous oxide inhalation on mood, psychomotor performance, and the pain response in humans.
- Trial name
- NCT00000262
- Testing
- 30% Nitrous oxide, 0.4% Sevoflurane, 0.2% sevoflurane
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Use of Nitrous Oxide During Office Hysteroscopy
The goal of this clinical trial is to assess the use of inhaled nitrous oxide during office hysteroscopy. The main questions it aims to answer are: Does it reduce pain during the procedure? Does it increase the success rate? Does…
- Conditions
- Abnormal Uterine Bleeding, Postmenopausal Bleeding, Endometrial Polyps, Retained Products of Conception
- Trial name
- NCT07074795
- Testing
- Inhalation of Nitrous Oxide (N₂O) during Office Operative Hysteroscopy, inhalation of ambient air during office hysteroscopy
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Maaynei Hayesha Medical Center
Pain, Anxiety
Lumbar Puncture in Emergency Under Nitrous OXide
Lumbar puncture (LP) is a frequent exam that can cause pain and anxiety. In a scheduled setting, it has been shown that nitrous oxide use during the procedure was able to reduce both pain and anxiety.
- Trial name
- LENOX (NCT03941990)
- Testing
- Fixed 50:50 mixture of nitrous oxide and oxygen
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pain
ANI and NoL Index Variations After Standard Nociceptive Stimulus at 0, 50, 25 % of Inhaled N2O in the Anesthetic Mixture
N2O has been used during general anesthesia (GA) for more than 100 years. It is known to have anesthetic agents sparing effect. But small is know on his real analgesic effect during GA.
- Trial name
- NCT02701478
- Testing
- N2O exposure
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Injection Site Vesicles
The Interest of the Nitrous Oxide During Intravesical Injection of Botulinum Toxin A
Second line treatment for detrusor hyperreflexia is the intravesical BTX-A injections. First 300 units Botox are diluted with 30 ml of preservative-free saline.
- Trial name
- PROTOTOX (NCT00948103)
- Testing
- Nitrous Oxide, Oxygen
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Anxiety
Nitrous Oxide for Lumbar Puncture
Lumbar puncture (LP) is a frequent exam that can cause pain and anxiety. In a pilot single-center study, it has been shown that nitrous oxide use during the procedure was able to reduce both pain and anxiety (Moisset et al., Eur…
- Trial name
- NO for LP (NCT03228628)
- Testing
- Fixed 50:50 mixture of nitrous oxide and oxygen
- Where
- France
- Volunteers
- 162 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lumbar Puncture
Impact of 50% Nitrous Oxide Inhalation on Pain and Anxiety Induced by Lumbar Puncture: a Double-blind Randomized Controlled Trial
This study is designed to evaluate the analgesic effect of nitrous oxide (N2O) on the pain induced during lumbar puncture.
- Trial name
- NCT02243826
- Testing
- 50:50 mixture of nitrous oxide/oxygen
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Leg Ulcer
Efficacy of 50% Nitrous Oxide/50% Oxygen Gas Premix in Chronic Leg Ulcer Debridement
Adequate analgesia in serial chronic leg ulcer debridement can be difficult to achieve. A common analgesia method is the topical administration of local anesthetics directly onto the wound.
- Trial name
- NCT02696460
- Testing
- N2O/O2 analgesia, Lidocaine/Prilocaine analgesia
- Volunteers
- 21 people
- Sponsor
- Venenklinik Bellevue