Clinical trials: Initial Caries
Sound Newly Erupted First Permanent Molars With Deep Fissures Susceptible to Caries
Evaluation of Retention for Hydrophilic and Hydrophobic Sealants in Uncooperative Children
To evaluate and compare the retention and cariostatic effect of hydrophilic and hydrophobic resin-based sealants for sealing pits and fissures of permanent molars in uncooperative children.
- Trial name
- NCT04560985
- Testing
- Hydrophilic fissure sealant, Hydrophobic fissure sealant
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
White Spot Lesion of Tooth
Color Masking Potential of Bioactive and ICON Materials
The non cavitated white-spot lesion (WSL) occurs after sometime during fixed orthodontic treatments, and their treatment is mandatory before going into frank cavitation.
- Trial name
- NCT06402500
- Testing
- Icon Infiltrant, Bioactive infiltrant
- Where
- Jordan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Dental Caries
Preventive Regimens With Herbal and Fluoride Toothpaste on Remineralization in High Caries Patients With Initial Lesions
This study will be conducted to assess the effect of different preventive regimens using herbal toothpaste versus fluoride toothpaste on the management of remineralization and caries risk in high caries risk patients.
- Trial name
- NCT04446390
- Testing
- Himalaya complete care toothpaste, colgate cavity protection
- Where
- 2 sites in Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries Assessment, Caries; Dentin
Evaluation of Radiation-Free Caries Detection Integrated Into Intraoral Scanners Compared With Conventional Diagnostic Methods
The goal of this study is to evaluate if an intraoral scanning device with an integrated radiation-free caries detection tool (near-infrared light) can detect early tooth decay.
- Conditions
- Caries Assessment, Caries; Dentin, Caries; Initial
- Trial name
- NCT07342595
- Testing
- intraoral scan with integrated caries detection tool
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Albert Mehl
Initial Dental Caries
Dentifrice With Innovative Remineralizing Technology
Objective: The aim of this study is to evaluate in vivo dentifrices containing different active ingredients in fluoride (F) retention in saliva and dental biofilm.
- Trial name
- REFIX (NCT04730908)
- Testing
- DENTIFRICE
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
White Spot Lesion of Tooth
Effect of Diode Laser With Dye and Remineralizing Agent on Surface Area of White Spot Lesions by Using Digital Subtraction Radiograph Techniques.
The current study was conducted to compare effect of diode laser and perio green dye with reminerlizing agent on surface area white spot lesions by using digital subtraction radiographic techniques.
- Trial name
- NCT07818655
- Testing
- remin pro
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Caries; Initial
Caries Inhibition With CO2-Laser During Orthodontic Treatment
The aim of the study is to assess the viability and efficacy of carbon dioxide laser in combination with a fluoride varnish in the prevention, severity, and extent of white spot lesions during orthodontic treatment with fixed…
- Trial name
- NCT04903275
- Testing
- Topical fluoride application and Laser irradiation, Topical fluoride application
- Where
- 2 sites in Bulgaria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Initial Proximal Caries
Diagnostic Accuracy of Near Infrared Transillumination in Combination With a Dye in the Cavitation Detection
The aim of the study will be to make a comparison in vivo of the following techniques: DIAGNOcam, DIAGNOcam in combination with indocyanine and bitewing radiography, analyzing the ability to detect cavitation in initial proximal…
- Trial name
- NCT04748913
- Testing
- Radiographic examination, Scanning with DIAGNOcam, Scan with DIAGNOcam and Indocyanine
- Where
- Spain
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
White Spot Lesion of Tooth
Caries Prevention Potential of Pearl Powder Versus CPP-ACP on Enamel White Spot Lesions
to evaluate the caries prevention potential of pearl powder against CPP-ACP in enamel white spot lesions.
- Trial name
- NCT03973554
- Testing
- pearl powder, CPP-ACP
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ruba Alaa El Din Adel El Damarisy
White Spot Lesion of Tooth
Clinical Outcomes, Cost-Effectiveness and Patient Satisfaction of Two Resin Infiltration Systems for The Management of White Spot Lesions
The aim of this study is to clinically evaluate and compare the color matching of white spot lesions (WSLs) following treatment with two resin infiltration systems: ICON resin infiltration and I-Mate resin infiltration.
- Trial name
- NCT07799350
- Testing
- light cured low viscosity resin infiltration
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries,Dental, Remineralization
Remineralization Efficacy of Gum Arabic Varnish.
The aim of this study is to evaluate the remineralizing capacity of Gum Arabic varnish and its implementation into clinical practice.
- Conditions
- Caries,Dental, Remineralization, White Spot Lesion
- Trial name
- NCT04422860
- Testing
- Gum Arabic varnish, Proflourid Varnish,VOCO, MI Varnish,GC Japan Inc.
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions[Initial Caries]on Smooth Surface of Tooth
Remineralization Effect of βTricalcium Phosphate Nanoparticles Versus FunctionalizedβTricalcium Phosphate Nanoparticles
The study collects Sixty non carious sound human permanent premolars from Tanta University's maxillofacial surgery department. The teeth are cleaned and prepared, and randomly assigned into four groups.
- Trial name
- NCT06561789
- Testing
- Functionalized Nano ᵦ tricalcium phosphate particles, Nano ᵦ tricalcium phosphate particles, sodium fluoride mouth wash
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aya Magdy Elsadany
White Spot Lesion of Tooth, Gingival Inflammation
EFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISED CONTROLLED CLINICAL TRIAL
This clinical trial aims to learn if water floss is as efficient as other interdental cleaning tools and can prevent plaque accumulation and white spot lesions (WSLs) in orthodontic patients.
- Conditions
- White Spot Lesion of Tooth, Gingival Inflammation, Gingival Bleeding, Dental Plaque
- Trial name
- WATER FLOSS (NCT06752291)
- Testing
- water flosser
- Where
- Malaysia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Malaya
White Spot Lesion of Tooth
Treatment of Postorthodontic White Spot Lesions
Dental caries is the destruction of the tooth structure in the presence of organic acids produced by cariogenic bacteria located in the dental biofilm (Dowker et al., 1999 and Robinson et al., 2000).Tooth enamel comprises 90%…
- Trial name
- NCT03217084
- Testing
- MI varnish GC, White varnish 3M
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion of Tooth
Remineralization Agents for the Treatment of White Spot Lesions
Clinically, formation of white spots can occur as early as 4 weeks into orthodontic treatment and very common in high caries risk individuals.
- Trial name
- NCT04827966
- Testing
- Clinpro® 5% sodium fluoride plus tri calcium phosphate varnish, Tooth Mousse® - Casein phosphopeptide-Amorphous calcium phosphate (CPP - ACP)s, MI Paste® -Casein phosphopeptide-Amorphous calcium phosphate fluoride (CPP-ACPF)
- Where
- Bahrain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Bahrain
White Spot Lesion of Tooth, Orthodontic Malocclusion
A Comparative Assessment of Orthodontic Treatment Outcomes Using the Quantitative Light-Induced Fluorescence Method
The aim of this 2-arm parallel trial was to evaluate enamel demineralization after an indirect bonding technique in comparison to a direct bonding technique group using the quantitative light-induced fluorescence method.
- Trial name
- QLF (NCT03738839)
- Testing
- Quantitative Light-Induced Fluorescence, Direct bonding, Indirect bonding
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Dental Caries Extending Into Dentin
Clinical Evaluation of Extensive Direct Composite Restorations With Polyethylene Fiber
The aim of this clinical trial was to compare the clinical performances of composite resin restorations with/without the polyethylene fiber to the first permanent molar teeth with extensively carious pediatric patients.
- Trial name
- NCT04612543
- Testing
- Genial Posterior Composite with Polyethylene Fiber, Genial Posterior Composite
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Caries; Initial, Pit and Fissure Caries
Retention Rate of Self-etch Resin Based Sealant With and Without Prior Sandblasting
The aim of the study is to clinically assess the effect of sandblasting prior to self-etch resin based sealant on its retention after one year follow up.
- Trial name
- NCT04929327
- Testing
- Self etch Pit and fissure sealant application (prevent seal), Self etch Pit and fissure sealant application (prevent seal) with prior sandblasting, Total etch resin based sealant ultraseal xt
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion of Tooth
RMGI Varnish Versus APF Gel in Prevention of White Spot Lesions During Orthodontic Treatment
evaluate the effect of a single application of Clinpro XT varnish on enamel demineralization adjacent to orthodontic brackets during fixed orthodontic treatment in comparison with acidulated phosphorus fluoride gel.
- Trial name
- NCT03721198
- Testing
- Acidulated phosphorous flouride, Resin modified glass ionomer varnish
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mohamed zidan
White Spot Lesion of Tooth
Incidence of White Spot Lesions Around Ceramic Brackets Compared With Metal Brackets
The main objective of this study was to investigate the relation between ceramic brackets and the development of white spot lesions (WSLs) compared to that associated with conventional metal brackets.
- Trial name
- NCT05764187
- Testing
- Orthodontic fixed appliance therapy
- Where
- Jordan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology