Clinical trials: Injection Pain
Rocuronium, Injection Pain
Median Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium
As a medium-and long-term non-depolarizing muscle relaxant, rocuronium has the advantages of quick effect, no histamine release and accumulation and no obvious cardiovascular adverse reactions, so it has been widely used in…
- Trial name
- NCT05217238
- Testing
- Remifentanil
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Injection Pain
Effect of TEAS on Rocuronium Injection Pain
Pain from the injection of rocuronium is a common side effect during anesthetic practice, occurring in 50%-80% of patients. Several methods have been used to reduce this pain.
- Trial name
- NCT04943367
- Testing
- TEAS
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Pain, Injection Site
Adalimumab Microneedles in Healthy Volunteers
Adalimumab (Humira, AbbVie) is a highly effective treatment for a variety of auto-immune/auto-inflammatory diseases including juvenile idiopathic arthritis (JIA).
- Trial name
- NCT03607903
- Testing
- Adalimumab ID, Adalimumab SC, Saline ID
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Human Drug Research, Netherlands
Injection Pain, Local Anesthesia
Efficacy of Virtual Reality in Reducing Injection Pain and Anxiety During Local Anesthesia in Children
The aim of this study is to determine the efficacy of a virtual reality (VR) device in reducing injection pain and anxiety associated with local anesthesia in pediatric dental patients.
- Trial name
- NCT03772483
- Testing
- Local anesthesia with conventional syringe, Local anesthesia with conventional syringe + VR device
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Intramuscular Injection
Effect of Manual Pressure and Shotblocker on Pain and Injection Satisfaction in Intramuscular Injection Application
This study was planned as a single blind randomized controlled experimental study to investigate the effect of manual pressure applied before injection and ShotBlocker's pain and injection satisfaction due to intramuscular…
- Trial name
- NCT04883723
- Testing
- Shotblocker, Manual Pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pain, Quality of Life
FLUAD® vs. Fluzone® High-Dose Study
The overall aim of the study is to compare safety and immunogenicity of inactivated influenza vaccine (IIV), adjuvanted (FLUAD®) versus High-Dose inactivated influenza (Fluzone® High-Dose) vaccine in persons ≥65 years (20% aged…
- Conditions
- Pain, Quality of Life, Injection Site Reaction, Side Effect of Drug
- Trial name
- NCT03183908
- Testing
- FLUAD®, Fluzone® High-Dose
- Where
- 4 sites in United States
- Volunteers
- 757 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain, Aromatherapy
The Effect of Aromatherapy on the Insulin Injection Pain
Needle phobia occurs in more than half of diabetic patients due to the pain caused by frequent insulin injection. Therefore, this study evaluated the effect of topically administered lavender aromatherapy on the pain of insulin…
- Conditions
- Pain, Aromatherapy, Subcutaneous Injections
- Trial name
- NCT04767737
- Testing
- Topically Administered Lavender Aromatherapy, Topically Administered Water
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Venomous Snakebites, Local Anesthesia
Subcutaneous Injection of Large Volumes of Tumescent Lidocaine and Epinephrine by Laypersons
This research is intended to show that it is safe and not difficult for nearly anyone to inject at least 125ml of a dilute solution of tumescent lidocaine and epinephrine (TLE), where a TLE solution consists of lidocaine (1gm/L)…
- Conditions
- Venomous Snakebites, Local Anesthesia, Painless Injection, Regional Anesthesia
- Trial name
- TLE-RCT (NCT04733781)
- Testing
- Tumescent Lidocaine and Epinephrine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Jeffrey Alan Klein, MD
Injection Site Irritation
Effects of Cyclooxygenase (COX) 1-2 Inhibitors on Prevention of Rocuronium Injection Pain
Purpose : The aim of the study is to investigate the effects of cox inhibitors as a rescue agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study.
- Trial name
- NCT04582032
- Testing
- Dexketoprofen (KETAVEL 50 mg/2 ml), Saline (Isotonic Saline Solution 0.9% )
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
The Influence of Timing of Botulinum Toxin Injection on Postoperative Pain Control
Botulinum Toxin Injection in Patients Undergoing Hemorrhoidectomy-A Prospective, Randomized Study
This is a prospective, randomized study, which anticipatedly recruited 60 patients in the outpatient department who need hemorrhoidectomy from January 2019 to December 2019.
- Trial name
- NCT04485780
- Testing
- botulinum toxin type A
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Lidocaine, Injection Pain
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated With Medium-/Long-chain Triglycerides
Propofol is widely used in general anesthesia induction, but the occurrence of peripheral intravenous pain is relatively high, causing anxiety, fear and other adverse emotions in patients , aggravating the stress response, and…
- Trial name
- NCT04008433
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Intravitreal Injection, Pain
Comfort Comparison of Intravitreal Injection Eyelid Retraction Techniques
This study evaluated the discomfort associated with eyelid retraction during intravitreal injections. Participants had eyelid retraction with one of three methods: eyelid speculum, unimanual eyelid retraction method or with a…
- Trial name
- Eyelid RETRACT (NCT04144985)
- Testing
- Visual analog scale (VAS) of pain to evaluate the discomfort participants experience.
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Injection Pain Prevention
Evaluation of Three Non-invasive Analgesic Techniques in Pain Prevention During Injections
Injections are associated to a certain level of pain which tolerance can vary between individuals. As regards non-invasive pain control techniques in subcutaneous injections, scarce literature exists with adequate levels of…
- Trial name
- NCT03974633
- Testing
- Injection
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Enrique Salmeron
Pain Control During Intravitreal Injections
Handheld Vibrator Versus Topical Eye Drops as Anesthesia for Intravitreal Injections
Intravitreal injections are an efficient method of delivering therapeutic levels of medications to the posterior segment of the eye. Prior to receiving an injection, there are various methods to provide ocular anesthesia.
- Trial name
- Eyebrator (NCT03079713)
- Testing
- Handheld vibrator triggered during intravitreal injection for wet ARMD, Normal eye esthesiometry with and without vibration, Handheld vibrator not triggered during intravitreal injection for wet ARMD
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Anesthesia, Local, Infiltration
A Trial Comparing Pain During Local Tumesent Injection In Fingers Using Different Syringe-Needle Combinations
Background: This study aims to obtain the most favorable syringe and needle combination, which causes the least pain during local anesthesia tumescent injection in the simulation of fully awake hand surgery.
- Conditions
- Anesthesia, Local, Infiltration, Injection Site, Pain
- Trial name
- NCT03736915
- Testing
- Injection using 1 cc of NaCl 0.9%, Patient Preference Question, Questionnaires
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Acute Pain, Injection
The Effect of Acupressure (GB30) on Ventrogluteal Intramuscular Injection Pain
Acupressure is an ancient manual therapy which fingers are used to press key points on the body. These points are the same with acupuncture points but in contrast to acupuncture, acupressure uses gentle but firm pressure with…
- Conditions
- Acute Pain, Injection, Needle Phobia
- Trial name
- NCT03553901
- Testing
- Acupressure
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Pain on IV Injection of Propofol.
Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection
The main objective is to evaluate if combining placing the Synera patch and using Propofol /Lidocaine mixture will further decrease the pain associated with the IV injection of Propofol.
- Trial name
- NCT02240628
- Testing
- Lidocaine/tetracaine transdermal patch, Saline, Lidocaine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Injection Site Irritation
The Prevention of Pain Associated With Rocuronium Injection
The purpose of this study is to determine whether efficacy of different doses of lidocain and acetaminophen for the prevention of rocuronium injection pain and frequency of withdrawal movements during the general anesthesia…
- Trial name
- NCT02524743
- Testing
- acetaminophen, Lidocaine
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Low Back Pain After Epidural Steroid Injection, Quality of Life After Epidural Steroid Injection
Statin and Epidural Steroid Injection
The impact of statin use on response to epidural steroid injections remains unknown and may well increase the effect considering the substantial anti-inflammatory properties.
- Trial name
- NCT02162940
- Testing
- Visual analogue score, The SF 36 test
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Pain on Injection of Propofol,Lidocaine, Alkalinized Lidocaine
Pain on Injection of Propofol: a Comparison of Lidocaine and Alkalinized Lidocaine
Aim: The aim of this study was to compare the efficacy of pretreatment 0.5 mg/kg lidocaine and 0.5 mg/kg alkalinized lidocaine for prevention of propofol induced pain.
- Trial name
- NCT01773044
- Testing
- alkalinized lidocaine, Lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Inonu University