Clinical trials: Injection Site Pain
Prostate Cancer, Anesthesia, Local
Open Radical Prostatectomy and Erector Spinae Plane Block
In the proposed study, a bilateral erector spinae plane (ESP) block [10 ml 1%lidocaine + 10 ml 0.5 % bupivacaine vs normal saline (NS)] will be performed preoperatively to patients undergoing open radical prostatectomy.
- Conditions
- Prostate Cancer, Anesthesia, Local, Pain, Postoperative
- Trial name
- NCT04337060
- Testing
- Single-injection ultrasound-guided bilateral erector spinae plane block-Lidocaine/Bupivacaine, Pain follow-up and monitorization
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- BURHAN DOST
Injection Site Irritation
Effect of Esmolol on Pain Due to Rocuronium
90 American society of anesthesiology (ASA) physical status I and II patients undergoing general anesthesia for elective surgery will be included in the study. Patients will be randomized into three groups.
- Trial name
- NCT01824758
- Testing
- Lidocaine, Esmolol, rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara Diskapi Training and Research Hospital
Hand Injury, Wrist Injury
Comparing Two Injection Sites of Local Anesthetic for Hand Surgery
The purpose of this study is to compare two different injection sites for local anesthesia in patients having hand surgery. The hypothesis is that subjects receiving injections around the three nerves of the forearm will provide…
- Conditions
- Hand Injury, Wrist Injury, Finger Injury
- Trial name
- NCT02112006
- Testing
- 0.5% bupivacaine injected in the forearm, 20-30ml of 0.5% bupivacaine.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Cancer, Oropharynx, Pain, Intractable
Ropivacaine/Dexamethasone and 10% Lignocaine Injection in GPN Block for Intractable Cancer Pain
The study will compare the efficacy and safety of Ropivacaine/dexamethasone vs 10% lignocaine injection in distal glossopharyngeal nerve block for intractable cancer pain
- Conditions
- Cancer, Oropharynx, Pain, Intractable, Cancer Pain
- Trial name
- NCT04085120
- Testing
- 0.75 % Ropivacaine/ 4mg/mL dexamethasone injection, 10% lignocaine injection
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Pain, Postoperative
Injection of Local Anesthetic to Trocar Insertion Sites After Laparoscopy
The primary objective of this study is to assess if injection of local anesthetic to the laparoscopic trocar sites after a hysterectomy will make a difference in a patient's pain after surgery.
- Trial name
- NCT01688596
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Milton S. Hershey Medical Center
TMJ Disc Disorder, Ultrasound Therapy; Complications
Ultrasound-Guided Vs Non-Guided Prolotherapy for Internal Derangement of Temporomandibular Joint. a Randomized Clinical Trial
Ultrasound Guided Versus Non-Guided Prolotherapy for Treatment of Internal Derangement of Temporomandibular joint. Rationale for conducting the research: The most critical cause for guided prolotherapy is to specify the accurate…
- Conditions
- TMJ Disc Disorder, Ultrasound Therapy; Complications, TMJ, Prolotherapy
- Trial name
- NCT05627830
- Testing
- Prolotherapy
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Crohn Disease, Ulcerative Colitis
The Evaluation of Injection Site Pain and Adherence in Patients Switching From a Low To High Concentration Adalimumab (AVT-02) Across Multiple Indications.
The purpose of the Phase IV study is to investigate the effects of both Volume and Citrate on Injection Site Pain (ISP), adherence, patient satisfaction, Quality of Life, and Disease Assessment in the Canadian Adalimumab Market.
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- EASE PAIN (NCT05913817)
- Testing
- AVT02 (Alvotech Biosimilar to Adalimumab)
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Jamp Pharma Corporation
Colorectal Cancer
Intra-op Lidocaine and Ketamine Effect on Postoperative Bowel Function
Bowel function after bowel surgery is delayed (postoperative ileus)by both opiates and the surgery itself. We hypothesized that decreasing opiate use by other analgesics will speed the return of bowel function after surgery.
- Trial name
- NCT00229567
- Testing
- Lidocaine infusion plus ketamine injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Healthy Volunteers Diabetes Mellitus, Type 2, Healthy Volunteers Overweight
A Study Comparing the Injection Site Pain Experience After the Injection of 2 Different Solutions of Semaglutide With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity
This study in healthy men and women compares the injection site experience of the DV3396 pen to that of the PDS290 pens when both pens are used to deliver 0.25 mg semaglutide subcutaneously (sc, under the skin).
- Conditions
- Healthy Volunteers Diabetes Mellitus, Type 2, Healthy Volunteers Overweight, Healthy Volunteers Obesity
- Trial name
- NCT04007107
- Testing
- Semaglutide (administered by DV3396 pen), Semaglutide (administered by PDS290 pen)
- Where
- Netherlands
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Injection Site Discomfort
Different Intravitreal Injection Techniques and Pain Level
The purpose of this study is to determine whether certain intravitreal injection techniques cause less pain than others and would therefore be beneficial for the patient's well being.
- Trial name
- NCT02497092
- Testing
- Technique of injection
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rabin Medical Center
Injection Site
The Effect of Intramuscular Ventrogluteal Injection Training Given by Pecha Kucha Method
The aim of this study is to determine the effect of intramuscular Ventrogluteal injection training given with the Pecha Kucha method on the knowledge, skill and satisfaction levels of nursing students.
- Trial name
- NCT06840353
- Testing
- Experimental group (Pecha Kucha training)
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Injection Site Irritation
Assessment of Pain on Propofol Injection.
Title: Assessment of pain on lidocaine-Propofol admixture injection: Comparing large antecubital vein and small vein dorsum of hand.
- Trial name
- NCT04673500
- Testing
- Propofol lidocaine through large vein, Propofol lidocaine through small vein
- Where
- Saudi Arabia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Khalid University Hospital
Opioid Use Disorder, Chronic Pain
Phase II Pharmacokinetics Study of CAM2038
Phase II, open label, partially randomized, three treatment group study designed to evaluate the steady state pharmacokinetics of buprenorphine and norbuprenorphine following repeated subcutaneous administrations of CAM2038.
- Trial name
- NCT02710526
- Testing
- CAM2038
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Braeburn Pharmaceuticals
Pain
The Effects of Injection Site Cooling and Solution Buffering on Perceived Pain During Local Anesthesia Administration
Participants will have local anesthesia administered to the palmar aspect of both forearms using 4 different injection methods in order to determine which method provides the best results in terms of perceived pain, overall…
- Trial name
- NCT04991597
- Testing
- Cold Compress Pack, Room Temperature Compress Pack, Lidocaine Epinephrine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nicholas Bastidas
Pain, Quality of Life
FLUAD® vs. Fluzone® High-Dose Study
The overall aim of the study is to compare safety and immunogenicity of inactivated influenza vaccine (IIV), adjuvanted (FLUAD®) versus High-Dose inactivated influenza (Fluzone® High-Dose) vaccine in persons ≥65 years (20% aged…
- Conditions
- Pain, Quality of Life, Injection Site Reaction, Side Effect of Drug
- Trial name
- NCT03183908
- Testing
- FLUAD®, Fluzone® High-Dose
- Where
- 4 sites in United States
- Volunteers
- 757 people, healthy volunteers welcome
- Sponsor
- Duke University
Colorectal Cancer
Pain Relief After Colorectal Surgery: Spinal Combined With Painbuster® vs Painbuster® Alone.
Limiting surgical stress and managing postoperative pain are well understood to influence recovery and outcome from major surgery for colorectal cancer and both are fundamental aspects of enhanced recovery protocols.
- Trial name
- PROSP (NCT02210260)
- Testing
- Spinal and infusion of local anaesthetic, Continuous infusion of local anaesthetic, Bupivacaine
- Where
- United Kingdom
- Volunteers
- 79 people
- Sponsor
- York Teaching Hospitals NHS Foundation Trust
Injection Site Inflammation, Upper Extremity Problem
Vibration Device Effect on Post-Injection Pain in the Upper Extremity
Background: Vibratory stimulation is one of several non-pharmacological techniques used to reduce pain. Local vibration therapy generates vibrations that can penetrate up to 6 centimeters into the tissue and is utilized to manage…
- Trial name
- NCT05651139
- Testing
- Electrical Vibration Device
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Hatan Mortada
Diabetic Macular Edema
Pain and Visual Outcome in Intravitreal Bevacizumab Injection
In this double blind clinical trial, 1000 patients suffering from diabetic macular edema, age-related macular degeneration, neovascularization due to proliferative diabetic retinopathy and cystoid macular edema secondary to…
- Trial name
- pain & visual (NCT02790775)
- Testing
- Anti-VEGF in quadrant 1, Anti-VEGF in quadrant 2, Anti-VEGF in quadrant 3
- Where
- Iran
- Volunteers
- 1,004 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cerebral Palsy, Hip Dysplasia
Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy
Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly.
- Conditions
- Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
- Trial name
- NCT04074265
- Testing
- Ropivacaine injection, normal saline
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of California, Los Angeles
Pain, Quality of Life
Simultaneous RZV and aIIV4 Vaccination
The overall aim of the study is to compare the safety of simultaneous Zoster Vaccine Recombinant, Adjuvanted (RZV) (SHINGRIX®) and Quadrivalent Influenza Vaccine, Adjuvanted (FLUAD®) versus simultaneous Zoster Vaccine…
- Conditions
- Pain, Quality of Life, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05007041
- Testing
- FLUAD® Quadrivalent, Fluzone® High-Dose Quadrivalent, SHINGRIX®
- Where
- 2 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Duke University