Clinical trials: Injection-related Infections
HIV Infections
A Phase II Study of Low-Dose Interleukin-2 by Subcutaneous Injection in Combination With Antiretroviral Therapy Versus Antiretroviral Therapy Alone in Patients With HIV-1 Infection and at Least 3 Months Stable Antiretroviral Therapy
PRIMARY: To examine the effect of aldesleukin ( IL-2 ) on viral activity in the blood. To determine the safety of low-dose IL-2 in combination with antiretroviral therapy versus antiretroviral therapy alone.
- Trial name
- NCT00000820
- Testing
- Aldesleukin
- Where
- 10 sites in United States
- Volunteers
- 104 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Meningitis, Cryptococcal, HIV Infections
An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
To evaluate the safety and effectiveness of fluconazole as an intravenous dose as initial treatment for acute cryptococcal meningitis followed by oral therapy in AIDS and non-AIDS patients.
- Trial name
- NCT00002077
- Testing
- Fluconazole
- Where
- 4 sites in United States
- Sponsor
- Pfizer
Cytomegalovirus Retinitis, HIV Infections
Valganciclovir in Patients With CMV Retinitis and AIDS Who Cannot Take Drugs by Injection
The purpose of this study is to make valganciclovir available, before it is approved for marketing, to HIV-infected patients who have cytomegalovirus (CMV) retinitis (eye infection) and cannot take drugs by injection.
- Trial name
- NCT00017784
- Testing
- Valganciclovir
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 500 people
- Sponsor
- Hoffmann-La Roche
Pneumonia, Pneumocystis Carinii, HIV Infections
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral / Oral Trimethoprim - Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
This is a randomized double-blinded controlled study comparing aerosolized pentamidine with trimethoprim plus sulfamethoxazole (TMP / PurposeX).
- Trial name
- NCT00002056
- Testing
- Pentamidine isethionate
- Where
- United States
- Sponsor
- LyphoMed
HIV Infections, Cytopenias
A Study of Granulocyte Colony-Stimulating Factor Plus Recombinant Erythropoietin Plus Zidovudine in Patients With AIDS or AIDS-Related Complex
To evaluate the safety, tolerance and biological activity of filgrastim (granulocyte colony-stimulating factor; G-CSF) given by daily subcutaneous (SC) injection prior to and concomitantly with erythropoietin (EPO) and zidovudine…
- Trial name
- NCT00002281
- Testing
- Filgrastim, Epoetin alfa, Zidovudine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Amgen
HIV Infections
Interleukin-2 Plus Anti-HIV Therapy in HIV-Infected Children With Weakened Immune Systems
The purpose of this study is to determine the safety of a drug called interleukin-2 (IL-2) given with anti-HIV therapy in children with HIV infection. This study will also determine the best dose of IL-2 to give children.
- Trial name
- NCT00006066
- Testing
- Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Diphtheria and Tetanus Toxoids Adsorbed, Tetanus and Diphtheria Toxoids Adsorbed
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 92 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Long-acting Injectable Antiretroviral Treatment to Improve HIV Treatment Among Justice-involved Persons Being Released to the Community
The federal research award entitles "Long-acting injectable antiretroviral treatment to improve HIV treatment among justice-involved persons being released to the community" aims to Conduct interviews with justice and treatment…
- Trial name
- NCT06704204
- Testing
- The first FDA-approved LAI ART regimen includes an integrase inhibitor, cabotegravir (CAB), and a non-nucleoside reverse transcriptase inhibitor, rilpivirine (RPV) combined 4 wks
- Volunteers
- 20 people
- Sponsor
- The Miriam Hospital
Human Immunodeficiency Virus, Opioid Use Disorder
Combined Injectable Treatment for HIV and OUD
This is study seeks to evaluate perspectives of a combined injectable treatment for HIV and OUD. Specifically, with the development of new long-acting medications such as cabotegravir co-administered with rilpivirine (CAB/RPV)…
- Trial name
- CHOICE (NCT05991622)
- Testing
- Combined LAI Treatment: Cabenuva and Sublocade
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Hepatitis C, Opioid Use Disorder
Rural New England Health Study (Phase 2)
This study will integrate mobile hepatitis C virus (HCV) testing and treatment with expanded syringe access in order to improve uptake of HCV testing and treatment, and reduce syringe sharing behavior in rural northern New…
- Conditions
- Hepatitis C, Opioid Use Disorder, IV Drug Usage
- Trial name
- DISCERNNE (NCT05466331)
- Testing
- Mobile Tele-HCV Care, Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Cytomegalovirus Retinitis, HIV Infections
A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the Eyes
To determine a clinically safe and effective dose of intravitreally injected ISIS 2922 and to compare the safety and efficacy of immediate versus delayed treatment in AIDS patients with previously untreated, peripheral…
- Trial name
- NCT00002355
- Testing
- Fomivirsen sodium
- Where
- 13 sites in United States
- Volunteers
- 60 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Herpes Simplex, HIV Infections
An Open, Multicenter Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With the Acquired Immunodeficiency Syndrome and Other Immunodeficiencies
To evaluate the safety and efficacy of intermittent intravenous (IV) foscarnet in the treatment of acyclovir-resistant herpes simplex virus (HSV) infections in AIDS patients and other immunocompromised patients.
- Trial name
- NCT00002272
- Testing
- Foscarnet sodium
- Where
- United States
- Sponsor
- Astra USA
Pneumonia, Pneumocystis Carinii, HIV Infections
Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy
To compare the use of pentamidine aerosol (inhaled mist) with the standard intravenous method of administration in patients with AIDS related Pneumocystis carinii pneumonia (PCP), to measure the amount of pentamidine aerosol that…
- Trial name
- NCT00000722
- Testing
- Pentamidine isethionate
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Phase I/II Study of Delayed-Type Hypersensitivity (DTH) Reactions to Intradermal HIV Envelope Antigen
To determine the frequency of delayed-type hypersensitivity (DTH) reactions in HIV-positive patients to two doses of two envelope glycoprotein antigens prepared differently.
- Trial name
- NCT00000782
- Testing
- gp160 Vaccine (Immuno-AG), gp160 Vaccine (MicroGeneSys)
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Phase I Safety, Efficacy, and Pharmacokinetic Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Patients With AIDS or AIDS Related Complex
To determine the safety, pharmacokinetics (blood levels), and effectiveness of didanosine (ddI) when administered both intravenously and orally.
- Trial name
- NCT00000710
- Testing
- Didanosine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Drug Use, Opioid-use Disorder
Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections
This study will assess the efficacy of an integrated outpatient treatment model for persons with opioid use disorder and injection related infections.
- Trial name
- BOPAT (NCT04677114)
- Testing
- Buprenorphine and Outpatient Parenteral Antibiotic Therapy, Buprenorphine and standard of care antibiotic treatment
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Laura Fanucchi
Age Related Macular Degeneration, Diabetic Macular Edema
Collateral Damage From the COVID-19 Pandemic Observed in Patients Treated With Intravitreal Injections (IVT) of Anti-angiogenic Agents
In patients treated for exudative age-related macular degeneration (AMD), diabetes, retinal venous occlusion (OVR), or other conditions causing macular edema, treatments with anti-angiogenic intravitreal injections (IVT) are…
- Conditions
- Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- COVIDIV (NCT04395859)
- Testing
- Questionnaire, Data collection up to 1 year
- Where
- 4 sites in France
- Volunteers
- 233 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Patients With Uncomplicated Long-term Central Venous Catheter-related Biofilm-related Infection
Conservative Treatment of Catheter - Related Injections With Gentamicine/EDTA
Catheter-related infections are frequent. Treatment without catheter removal is difficult because of the presence of biofilm. The association of gentamicin and EDTA is active in vitro and in vivo against biofilms formed by Gram…
- Trial name
- CATH-GE (NCT04789928)
- Testing
- Gentamicins-EDTA
- Where
- 6 sites in France
- Volunteers
- 8 people
- Sponsor
- Institut Pasteur
Hepatitis B, Chronic
A Phase II Study of Hepalatide in Subjects With Chronic Hepatitis B
A Phase II Randomized, Double-blind, Placebo-controlled, Multi-center, Dose-effect Relationship Study of Hepalatide for Injection Combined with Pegylated Interferon in Subjects with Chronic Hepatitis B
- Trial name
- NCT04426968
- Testing
- Hepalatide 2.1mg, Hepalatide 4.2mg, Hepalatide 6.3mg
- Where
- 12 sites in China
- Volunteers
- 96 people
- Sponsor
- Shanghai HEP Pharmaceutical Co., Ltd.
Opioid-related Disorders, HIV Infections
Project BEST: Buprenorphine Entry Into Substance Abuse Treatment
Project BEST is a clinical project funded by the Substance Abuse and Mental Health Services Administration (SAMHSA) to increase treatment to opiate dependent patients with mental illness in New Haven, CT and to prospectively…
- Conditions
- Opioid-related Disorders, HIV Infections, Hepatitis C, Chronic, Depression
- Trial name
- NCT02583243
- Testing
- MET/CBT based individualized counseling, Buprenorphine
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Yale University
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Two Forms of Pentamidine in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
To compare parenteral versus inhaled pentamidine in patients with documented Pneumocystis carinii pneumonia (PCP) with AIDS.
- Trial name
- NCT00002292
- Testing
- Pentamidine isethionate
- Where
- United States
- Sponsor
- LyphoMed