Clinical trials: Injections
Primary Immune Thrombocytopenia (ITP)
An Open-label Study of Intravenous Immunoglobulin (5%) for the Treatment of Primary Immune Thrombocytopenia
It is a clinical trial of a medicinal product Human Immunoglobulin for Intravenous Injection (5%) manufactured by Grand Shuyang Life Sciences (Chengdu) Co., Ltd. (hereinafter referred to as 5% IVIG).
- Trial name
- NCT07233213
- Testing
- Human immunoglobulin (pH4) for intravenous injection
- Where
- 9 sites in Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Grand Shuyang Life Sciences (Chengdu) Co., Ltd.
Pain Assessment
Effect of Starpen CCLAD in Injection and Extraction
The present study aims to evaluate the effect of computer-controlled Starpen automatic injection device versus the traditional syringe on pain perception during Injection of nerve block anesthesia and extraction of mandibular…
- Trial name
- Starpen CCLAD (NCT06827223)
- Testing
- computer-controlled Starpen Automatic Injection Device, Traditional Syringe
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
T2DM
A Phase 1 Trial to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SHR-3167 Single Injection in Healthy Subjects and Patients With Type 2 Diabetes
This is a randomized, double-blind, placebo-controlled, single-dose escalation trial was designed. There are 6 dose groups and 1 optional dose group: 0.5 mg, 2 mg, 8 mg, 25mg, 50 mg, 100 mg and 150 mg (optional).
- Trial name
- NCT05996380
- Testing
- SHR-3167
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Asthma
Long Term Special Drug Use Investigation of Mepolizumab
This study is a special drug use investigation program of NUCALA (a brand name for Mepolizumab) administered subcutaneously (SC).
- Trial name
- NCT03028480
- Testing
- NUCALA Injection
- Volunteers
- 1,061 people
- Sponsor
- GlaxoSmithKline
Premixed, Sequential
Premixed vs Sequential Injections of Lidocaine and Bupivacaine for Supraclavicular Brachial Plexus Block in Patients Undergoing Arteriovenous Fistula Creation
This study aims to compare premixed and sequential injections of lidocaine and bupivacaine for supraclavicular brachial plexus block in patients undergoing arteriovenous fistula creation.
- Conditions
- Premixed, Sequential, Lidocaine, Bupivacaine
- Trial name
- NCT06570096
- Testing
- Lidocaine 2% then bupivacaine 0.5%, Lidocaine 2% and bupivacaine 0.5%
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Advanced Solid Tumors
A Study of Sirolimus for Injection (Albumin Bound) in Patients With Advanced Solid Tumors
The purpose of this study is to estimate the safety, tolerability, pharmacokinetics (PK), and antitumor activity of Sirolimus for Injection (Albumin Bound) in patients with solid malignancies.
- Trial name
- NCT05125523
- Testing
- Sirolimus for Injection (Albumin Bound)
- Where
- China
- Volunteers
- 264 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Cerebrovascular Disorders, Spasticity, Muscle
The Effect of Ultrasound-Guided Botulinum Toxin Injections on Pain, Functionality, Spasticity, and Range of Motion in Patients With Post-Stroke Upper Extremity Spasticity
The patients between the ages of 35-80 who developed spasticity in the upper extremity after stroke will be included.. Botulinum toxin(BT-A) injection will be applied to the study group(n=16) and placebo injection to the control…
- Conditions
- Cerebrovascular Disorders, Spasticity, Muscle, Botulinum Toxin
- Trial name
- NCT05887479
- Testing
- Botulinum toxin type A, %0,9 NaCl
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Advanced Adult Hepatocellular Carcinoma
Trans-catheter Chemo-embolization Combined With rAd-p53 Gene Injection in Treatment of Advanced Hepatocellular Carcinoma
Treatment options for advanced hepatocellular carcinoma (HCC) are limited due to patients' poor condition, advanced tumor, concomitant intra- and extra-liver diseases, and resistance to both chemo- and radio-therapy.
- Trial name
- NCT02418988
- Testing
- TACE plus rAd-p53 artery injection, TACE
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenzhen SiBiono GeneTech Co.,Ltd
Thoracic Outlet Syndrome, Whiplash Injuries
Whiplash-induced Thoracic Outlet Syndrome Treated With Botulinum Toxin.
Whiplash injuries following car accident are common, it has been reported to affect 83% of individuals injured in traffic collisions (Yadla S, 2007).
- Trial name
- NCT05536570
- Testing
- IncobotulinumtoxinA 100 UNT
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- King, David, MD
Non-small Cell Lung Cancer Metastatic
An Early Stage Study to Evaluate Oba01 for Injection in Patients With DR5 Positive LA/mNSCLC
This study will evaluate the safety, tolerability, pharmacokinetics and efficacy of Oba01 for injection in patients with DR5 positive LA/mNSCLC.
- Trial name
- NCT06083870
- Testing
- Oba01
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Lu Shun
Endometriosis, Fibroids
Evaluating Tibolone Add-back in Patients With Endometriosis and Fibroids
While there are many medical options for managing endometriosis and fibroids, GnRH-agonist (GnRH-a) therapy remains a very common method of treating these complex conditions.
- Trial name
- eTAPE (NCT05568940)
- Testing
- Tibolone 2.5 Mg Oral Tablet
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Periodontitis
Injectable Platelet Rich Fibrin in Periodontal Treatment
The aim of this randomized controlled parallel clinical trial is to investigate the efficacy of injectable Platelet Rich Fibrin (iPRF) as an adjunctive to non-surgical periodontal therapy (STEP 1 \& 2 of periodontal treatment).
- Trial name
- I-PRF (NCT06814418)
- Testing
- Non-surgical periodontal treatment, Injectable Platelet Rich Fibrin (I-PRF)
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Aristotle University Of Thessaloniki
Atrial Fibrillation, Atrial Fibrillation (Paroxysmal)
Wide-Antral Pulmonary Vein Isolation in Atrial Fibrillation Ablation with a Single-shot Technique (WIDER-PVI)
The WIDER PVI study is a multicentre randomized clinical trial to compare the efficacy of antral versus extended antral PVI in patients with paroxysmal or persistent AF undergoing this procedure using a cryoablation balloon…
- Trial name
- WIDER-PVI (NCT06698159)
- Testing
- Cryoablation with cryoballoon 28 mm, Cryoablation with cryoballoon 31 mm
- Where
- 17 sites in Italy, Spain
- Volunteers
- 440 people
- Sponsor
- Hospital Universitario 12 de Octubre
Plasma Cell Leukemia
A Study of CT0596 in Plasma Cell Leukemia
This study is a single-arm, open-label, exploratory dose-escalation and dosefinding clinical trial to evaluate the safety, efficacy, cellular pharmacokinetics and pharmacodynamics of CT0596 cells in patients with PCL.
- Trial name
- NCT06988059
- Testing
- CAR-T cells Infusion chimeric antigen receptor T cells
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Local Anesthesia
Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia
The purpose of this study is to determine the optimal amount of lidocaine buffering needed to decrease injection pain when administering local anesthesia.
- Trial name
- NCT02647892
- Testing
- lidocaine, sodium bicarbonate
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Nebraska
Diabetes Mellitus
The Relative Bioavailability of INS068 Injection With Two Different Formulations in Healthy Subjects
The study is a single-centre, randomized, open, 2-period, 2-sequence crossover design clinical trial. It is planned to enroll 24 healthy male subjects. Subjects will receive INS068 injection on Day1 and Day8.
- Trial name
- NCT05336071
- Testing
- INS068 injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Irreversible Pulpitis
Effect of Sufentanil on the Rate of Anesthesia
The aim of this study was to compare the effects of Lidocaine/epinephrine with and without Sufentanil on the rate of anesthesia after supplemental intraligamentary injection (PDL) in teeth with irreversible pulpitis.
- Trial name
- NCT01572116
- Testing
- Lidocaine with Epinephrine+ Normal saline, Lidocaine with Epinephrine + sufentanil
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Interscalene Block, Shoulder Arthroscopy
Prolongation of Pain Free Time by the Use of Dexamethasone in Peripheral Nerve Blockade
The main aim of the study is to investigate the proven effect of dexamethsone on the duration of the interscalene block. The investigators try to define optimal dose and volume for ropivacaine, when used together with…
- Conditions
- Interscalene Block, Shoulder Arthroscopy, Dexamethasone, Low Volume Regional Anesthesia
- Trial name
- NCT02178449
- Testing
- Dexamethasone acetate, Ropivacaine
- Where
- 2 sites in Austria
- Volunteers
- 109 people
- Sponsor
- Landesklinikum Sankt Polten
Ultrasound Guided Injection
Ultrasound-guided Intervention and Hand Tenosynovitis in Patients With Diabetes Mellitus
Evaluates the efficacy of ultrasound guided versus clinically guided steroid injection in the management of tenosynovitis in DM patients.
- Trial name
- NCT03789526
- Testing
- ultrasound guidance
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Al-Azhar University
Schizophrenia, Schizoaffective Disorder
Safety and PK Trial With Injectable ZX003 (Risperidone-SABER®) Compared to Risperdal® Consta® in Stable Schizophrenia
This is an open-label, multiple dose, PK and safety study in patients with chronic, stable schizophrenia or schizoaffective disorder.
- Trial name
- NCT02411526
- Testing
- ZX003 (Risperidone-SABER®), Risperdal Consta, Oral Risperidone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Zogenix, Inc.
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