Clinical trials: Injections
Diffuse Large B-Cell Lymphoma
Mitoxantrone Hydrochloride Liposome Injection in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
A multicenter, single-arm, phase 2 study of mitoxantrone hydrochloride liposome injection in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL).
- Trial name
- NCT05875428
- Testing
- Mitoxantrone Hydrochloride Liposome Injection
- Where
- China
- Volunteers
- 104 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Diabetes Mellitus Type 2
The Necessity of an Injection-Meal-Interval in Patients With Type 2 Diabetes Mellitus and Therapy With Human Insulin
The purpose of the study is to demonstrate, that there is no difference in metabolic control in patients with type 2 diabetes mellitus and therapy with human insulin with or without injection-meal-interval.
- Trial name
- NCT00529165
- Testing
- injection-meal-interval
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Jena
Advanced Gynecologic Tumors, TIL Engineered With Membrane-Binding Cytokine
A Study of GC203 TIL in Advanced Gynecologic Tumors (10hospital)
This study is to investigate the safety and efficacy on TIL engineered with membrane-binding cytokine (GC203 TIL) for the treatment of patients with advanced gynecologic tumors.
- Conditions
- Advanced Gynecologic Tumors, TIL Engineered With Membrane-Binding Cytokine, Treatment Side Effects, Effects of Immunotherapy
- Trial name
- NCT05468307
- Testing
- Membrane Bound Cytokine Modified TIL
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Shanghai Juncell Therapeutics
Dry Age-related Macular Degeneration, Geographic Atrophy
Intravitreal AAVCAGsCD59 for Advanced Dry Age-related Macular Degeneration (AMD) With Geographic Atrophy (GA)
Patients with advanced dry AMD with GA meeting inclusion criteria will be randomized in one eye in a 1:1:1 ratio comparing intravitreal high or low dose AAVCAGsCD59 with a sham injection.
- Conditions
- Dry Age-related Macular Degeneration, Geographic Atrophy, Gene Therapy, Intravitreal Injection
- Trial name
- NCT04358471
- Testing
- Intravitreal AAVCAGsCD59
- Sponsor
- Hemera Biosciences
Drug Drug Interaction (DDI), Pharmacokinetics and Pharmacodynamics
Phase I Drug-Drug Interaction Study of UBT251 Injection in Participants With Overweight or Obesity
This is a Phase I, open-label, two-cohort study designed to evaluate the drug-drug interaction potential of multiple-dose UBT251 Injection in adult participants with overweight or obesity.
- Trial name
- NCT07785934
- Testing
- UBT251, Metformin hydrochloride, Warfarin Sodium
- Where
- China
- Volunteers
- 48 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
Age-Related Macular Degeneration
Macugen (Pegaptanib Sodium) Alone, Versus Macugen in Combination With PDT (Photodynamic Therapy) With Visudyne (Verteporfin) in Patients With Age-Related Macular Degeneration (AMD)
The purpose of the trial is to compare whether Macugen (pegaptanib sodium) in combination with PDT with Visudyne (verteporfin) is safe and effective in slowing down the leakage of fluid within the eye and thereby stabilizing or…
- Trial name
- NCT00134667
- Testing
- Photodynamic Therapy (PDT) with Visudyne (verteporfin), Macugen (pegaptanib sodium)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Eyetech Pharmaceuticals
Transfer Dysphagia, Oropharyngeal Dysphagia
Onabotulinum Toxin A (Botox) in the Treatment of Pharyngo-esophageal Dysphagia
Dysphagia in patients with stroke, multiple sclerosis, parkinsonism or dystonia can occur due to relative hypertonia of the cricopharyngeus muscle. In the resting state, muscle is contracted and relaxes only during deglutition.
- Conditions
- Transfer Dysphagia, Oropharyngeal Dysphagia, Cricopharyngeus Muscle Dysfunction
- Trial name
- NCT04695600
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Solid Tumor, Adult
Autologous Tumor-Infiltrating Lymphocyte (GT307 Injection ) for Treatment of Patients With Solid Tumours
This study is a single arm, open design aimed at evaluating the safety and tolerability of Autologous Tumor-Infiltrating Lymphocyte (GT307 injection ) for treatment of patients with solid tumours,while evaluating pharmacokinetic…
- Trial name
- NCT06397963
- Testing
- GT307 injection
- Where
- 3 sites in China
- Volunteers
- 18 people
- Sponsor
- Grit Biotechnology
Pain, Anxiety
Comparison of Different Methods for Reducing Pain From Influenza Vaccine Injections
The purpose of this study is to compare four different analgesic strategies in adults undergoing routine influenza immunization
- Trial name
- NCT01006187
- Testing
- Liposomal lidocaine, Vapocoolant spray, Rubbing adjacent to the injection site
- Where
- Canada
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Gastric Cancer
Evaluating the Safety and Efficacy of SB Injection in Patients With Advanced or Metastatic Gastric Cancer
The purpose of this study is to determine efficacy of SB injection in Gastric Cancer.
- Trial name
- NCT01305993
- Testing
- SB injection
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- SBPharmaceutical IND, Co., LTD
Knee Osteoarthritis, HA Injection
Analyzing Composition and Lubrication Properties of Synovial Fluid
To analyze the relationship between composition of synovial fluid and its lubrication properties
- Conditions
- Knee Osteoarthritis, HA Injection, One Injection Per Week for Five Week, Synovial Fluid Composition
- Trial name
- SFCL (NCT00912106)
- Testing
- Synovial fluid composition and lubrication analysis
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- Far Eastern Memorial Hospital
Opioid Use Disorders
Clinical Trial of CAM2038, Long-acting Subcutaneous Buprenorphine Injections for Treatment of Patients With Opioid Dependence
Phase III, randomized, double-blind, double-dummy, active-controlled, parallel group multi-center trial, designed to evaluate the non-inferiority of CAM2038 compared to an existing standard of care (SL BPN/NX) in initiation and…
- Trial name
- NCT02651584
- Testing
- CAM2038 SC injection, SL BPN/NX tabs
- Where
- 36 sites in United States
- Volunteers
- 428 people
- Sponsor
- Braeburn Pharmaceuticals
Hypoparathyroidism
A Survey to Assess Participants' and Physicians' Knowledge, Attitudes and Behavior When Using NATPARA
This main aim of this study is to check the level of knowledge and assess attitudes and behaviors of both participants and prescribing physicians regarding the risks and safe use of NATPARA.
- Trial name
- NATPARA KAB (NCT05556629)
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Shire
Hematologic Malignancies
This Study is a FIH Study Which is Required to Understand the PK Characteristics, MTD, RP2D and Safety Profile.
This study is a first-in-human (FIH) study which is required to understand the safety, tolerability, pharmacokinetics and preliminary efficacy of RJK-RT2831 injection in patients with hematologic malignancies
- Trial name
- NCT06756451
- Testing
- RJK-RT2831 dose-escalation phase Ia, RJK-RT2831 Dose Expansion Phase Ib
- Where
- 16 sites in China
- Volunteers
- 71 people
- Sponsor
- Nanjing RegeneCore Biotech Co., Ltd.
Infertility
Hysterosalpingography and Hysteroscopy in ICSI
unexplained infertility is a rising problem in clinical practice
- Trial name
- NCT04778319
- Testing
- occlusion of tubes, non occlusion of tubes
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aljazeera Hospital
Macular Degeneration
Open-Label Posterior Juxtascleral Injections of Anecortave Acetate 15mg Dose for Long Term Use in Patients With AMD
The purpose of this study is to investigate the long-term efficacy and safety of posterior juxtascleral injections of open label Anecortave Acetate 15mg administered every 6 months.
- Trial name
- NCT00065728
- Testing
- Anecortave Acetate (AL-3789) Sterile Suspension, 30 mg/mL
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Alcon Research
Plantar Fasciitis
Dehydrated Human Amnion/Chorion Membrane Micrografts(dHACM) Injectable in the Treatment of Recalcitrant Plantar Fasciitis
This is a prospective, controlled, randomized, blinded and comparative, single-center clinical trial comparing the improvement of patients with recalcitrant plantar fasciitis symptoms that have received standard of care versus…
- Trial name
- dHACM (NCT01996111)
- Testing
- Injection of 1.0 cc of 0.9% Saline, Injection of 1.0 cc of 10 mg/ml micrograft dHACM suspension, Injection of 1.0 cc of 20 mg/ml micrograft dHACM suspension
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- MiMedx Group, Inc.
Acute Coronary Syndrome, Coronary Artery Disease
Comparison of Intravenous Injection of Calcium Antagonist and Beta-blockade on Endothelial Shear Stress of Coronary Artery
Both calcium channel antagonist and beta-blocker have cardioprotective effect. Endothelial shear stress is predictive factor of clinical outcomes in patients with obstructive stenosis.
- Trial name
- NCT01171911
- Testing
- Nicardipine , Esmolol
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Diabetes Mellitus, Steroid Diabetes
Effect of Corticosteroid Injections on Blood Glucose
The purpose of this study is to measure the effect of various corticosteroids administered to the shoulder, knee and hip joints in diabetic patients on resultant blood glucose readings.
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Shoulder Osteoarthritis, Knee Osteoarthritis
- Trial name
- CSI (NCT05048264)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Age-Related Macular Degeneration
Study of Safety and Efficacy of Brolucizumab 6 mg Dosed Every 4 Weeks Compared to Aflibercept 2 mg Dosed Every 4 Weeks in Patients With Retinal Fluid Despite Frequent Anti-VEGF Injections
This clinical study was designed to compare the safety and efficacy of brolucizumab 6 mg dosed every 4 weeks to aflibercept 2 mg dosed every 4 weeks in those neovascular age-related macular degeneration (nAMD) patients with…
- Trial name
- MERLIN (NCT03710564)
- Testing
- Brolucizumab, Aflibercept
- Where
- 61 sites in United States, Puerto Rico
- Volunteers
- 535 people
- Sponsor
- Novartis Pharmaceuticals
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