Clinical trials: Injections
Infertility, Donor Oocyte Assisted Reproduction
Fresh Versus Vitrified-Warmed Donor Oocytes: Embryological and Clinical Outcomes
This multicenter retrospective observational study compares embryological and clinical outcomes following treatment with fresh versus vitrified-warmed donor oocytes at Bocian Fertility Clinic centers in Poland.
- Trial name
- FRESH-FROZEN (NCT07904936)
- Testing
- Fresh Donor Oocyte ICSI, Vitrified-Warmed Donor Oocyte ICSI
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Center for Reproductive Medicine Bocian
Drug-specific Antibodies, Diabetes Mellitus
Evaluate the Immunogenicity of a Novel Glucagon Formulation
This study provides information on immunogenicity of Nasal Glucagon (AMG504-1) with regards to the potential development of treatment-emergent anti-glucagon antibodies.
- Trial name
- NCT01959334
- Testing
- Nasal Glucagon (NG), Glucagon IM
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Eli Lilly and Company
Pain of Anesthesia at Breast Biopsy
Reducing Pain of Lidocaine Injection
The purpose of this study is to determine the benefit, if any, of buffering lidocaine (adding sodium bicarbonate) when used for local anesthesia prior to percutaneous breast needle core biopsies.
- Trial name
- NCT02288364
- Testing
- 1% Lidocaine, 1% Lidocaine plus sodium bicarbonate
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Duke University
Adrenal Insufficiency
Management of Adrenal Emergency in Germany
The management of adrenal crisis is often problematic and the time to adequate treatment is frequently delayed.The aim of the study is to evaluate the management of adrenal emergencies requiring parenteral glucocorticoid…
- Trial name
- MAdEy (NCT03426332)
- Testing
- No intervention
- Volunteers
- 150 people
- Sponsor
- Wuerzburg University Hospital
Polycystic Ovary Syndrome, Infertility
Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients
Investigators will evaluate and compare the efficacy of Sitagliptin/Metformin to metformin and sitagliptin on gdf9 and bmp15 gene expression on PCOS patients undergoing intracytoplasmic sperm injection(ICSI).
- Conditions
- Polycystic Ovary Syndrome, Infertility, ART
- Trial name
- NCT04268563
- Testing
- metformin, Sitagliptin, Sitagliptin/metformin
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Chronic Ischemic Heart Disease, Coronary Artery Disease
Cell Therapy in Severe Chronic Ischemic Heart Disease
Patients with advanced coronary artery disease usually undergo incomplete myocardial revascularization due to the extension and diffuseness of the disease, with very poor distal arterial beds unsuitable for direct…
- Conditions
- Chronic Ischemic Heart Disease, Coronary Artery Disease, Angina Pectoris
- Trial name
- MiHeart (NCT01727063)
- Testing
- Cell Therapy
- Where
- Brazil
- Volunteers
- 143 people
- Sponsor
- Ministry of Health, Brazil
Alveolar Soft Part Sarcoma
Clinical Trials of Benmelstobart Injection Combined With Anlotinib Hydrochloride Capsules in the Treatment of Advanced or Unresectable Alveolar Soft Part Sarcoma
This is a Phase II, single-arm, multicenter clinical study aimed at demonstrating the effectiveness of benmelstobart injection combined with anlotinib hydrochloride capsules in patients aged 14 years or older with advanced or…
- Trial name
- NCT07548177
- Testing
- Benmelstobart injection combined with Anlotinib hydrochloride capsule
- Where
- 15 sites in China
- Volunteers
- 33 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Prevention of Arterial and Venous Thrombosis
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Single-dose Injection of SHR-2004 in Healthy Subjects
The primary objective of this study is to assess the safety and tolerability of SHR-2004 injection in healthy subjects. In addition, this study will provide information on pharmacokinetics and pharmacodynamics of SHR-2004…
- Trial name
- NCT05369767
- Testing
- SAD, SHR-2004
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Pompe Disease Infantile-Onset
Evaluation of the Safety and Efficacy of Infantile-onset Pompe Disease Gene Therapy Drug
This study is being conducted to evaluate the safety and effectiveness of GC301 adeno-associated virus vector expressing codon-optimized human acid alpha-glucosidase (GAA) as potential gene therapy for Pompe disease.
- Trial name
- NCT05793307
- Testing
- GC301
- Where
- 5 sites in China
- Volunteers
- 16 people
- Sponsor
- GeneCradle Inc
Advanced Lung Cancer
Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer
This Ib / IIa clinical trial program focuses on the small cell lung cancer (SCLC), Squamous non-small cell lung cancer (NSCLC) and adeniform NSCLC in order to start a better development on the broad-spectrum value of chlorogenic…
- Trial name
- NCT03751592
- Testing
- Chlorogenic acid
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd
In Vitro Fertilization
EXpression PRofile Endometrium Samples Study
This is a Phase IV, pilot, open-label, national, multi-centric study planned to determine the gene expression profiles and histologic changes of the endometrial tissue before and after stimulation with Gonal-f®.
- Trial name
- EXPRESS (NCT01210144)
- Testing
- Gonal -f® [r-hFSH], Ovitrelle® [r-hCG alfa], Gonadotropin-releasing hormone (GnRH) Agonist
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP
To evaluate the safety and effectiveness of trimetrexate (TMTX) given at increasing doses along with the leucovorin calcium (LCV) for treating Pneumocystis carinii pneumonia (PCP) in AIDS patients TMTX is an experimental new drug…
- Trial name
- NCT00000998
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Wrinkle
Association of Photobiomodulation With Platelet Rich Plasma Intradermal Injection for Facial Rejuvenation
Skin aging is an irreversible, slow and progressive process. It is influenced mainly by age, but also by external factors such as ultraviolet radiation, smoking, alcohol, among others.
- Trial name
- NCT04145999
- Testing
- PRP application, Photobiomodulation
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Pancreatic Adenocarcinoma
Effect of Intratumoral Injection of Gene Therapy for Locally Advanced Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is the fifth leading cause of cancer-related death in Western countries, and its incidence has increased over the last 40 years.
- Trial name
- THERGAP-02 (NCT02806687)
- Testing
- Gene Therapy product CYL-02, Gemcitabine
- Where
- 7 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Toulouse
Acute Coronary Syndrome
Reduce Bolus Injection of Bivalirudin
There are fewer studies on the bleeding risk of the currently administered bivalirudin bolus injection dose and the safety of bivalirudin in patients with CKD.
- Trial name
- NCT03588611
- Testing
- Bivalirudin
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Han Yaling, MD
Acute Ischemic Stroke (AIS)
A Phase I Clinical Trial Evaluating the Safety, Tolerability and Pharmacokinetics of AAPB for Injection
This is a Phase I clinical to evaluate the safety and tolerability of single and multiple intravenous infusions of AAPB at different doses over 7 consecutive days.
- Trial name
- AAPB (NCT06679998)
- Testing
- Single dose, AAPB by injection, intravenous drip., Multiple dosing, AAPB for injection, intravenous drip
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jiangsu Kanion Pharmaceutical Co., Ltd
Recurrent Glioblastoma
A Study of BL-B01D1 in Patients With Recurrent Glioblastoma
This is an open-label, multicenter, phase II study to evaluate the safety, efficacy, and pharmacokinetic characteristics of BL-B01D1 for Injection in patients with recurrent glioblastoma.
- Trial name
- NCT06598787
- Testing
- BL-B01D1 for Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Reproductive Techniques, Assisted
Endometrial Volume and Sub-endometrial Vascularity as Predictors of In-vitro Fertilization Success
100 patients aged 21-40 years old, diagnosed as primary or secondary infertility These patients are then assigned to receive ICSI treatment (ovulation induction, .
- Trial name
- NCT02381821
- Testing
- 3 D ultrasound and Doppler examination, GnRH agonist
- Volunteers
- 82 people
- Sponsor
- Cairo University
Advanced Tumors
Clinical Study to Evaluate the Tolerability and Pharmacokinetics of TQB2916 Injection in Patients With Advanced Malignant Tumors
This project is an open, dose escalation and expansion phase I clinical study. The first phase is a dose escalation study, and the second phase is a dose expansion study based on the Maximum tolerated dose (MTD) / Recommended…
- Trial name
- NCT05213767
- Testing
- TQB2916 injection
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Schizophrenia, Psychosis
Long-acting Injectable Antipsychotics for Mental Ill-Health in Pregnancy and Postpartum
The goal of this observational study is to learn about how long-acting injectable antipsychotic (LAIA) medications are affected by the changes that take place in the body during pregnancy, and how much an unborn baby is exposed…
- Conditions
- Schizophrenia, Psychosis, Mania, Pregnancy
- Trial name
- LAMP (NCT05766007)
- Where
- 6 sites in Nigeria
- Volunteers
- 168 people
- Sponsor
- University of Liverpool
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